Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 361 to 420 of 15,838 scaffolds
N-Cyclohexylbenzamide67 chemicals, 2 rings
1,2-Diphenoxyethane67 chemicals, 2 rings
O=C1C(=O)N(Cc2cccnc2)C(c2ccccc2)C1=Cc1ccccc167 chemicals, 4 rings
1-Cyclopropyl-1H-pyrazole67 chemicals, 2 rings
N-Phenyl-1,3,5-triazin-2-amine67 chemicals, 2 rings
O=C(Nc1ccccc1)c1ccc(-c2ccccc2)o166 chemicals, 3 rings![Scaffold O=C(CSc1nc2sccc2c(=O)[nH]1)Nc1ccccc1](/scaffold/MARXCFURZAQEIW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2sccc2c(=O)[nH]1)Nc1ccccc166 chemicals, 3 rings
Bicyclo(3.1.1)heptane66 chemicals, 3 rings
1-Anilino-anthraquinone66 chemicals, 4 rings
O=C(COc1ccccc1)NN=Cc1ccc(OCc2ccccc2)cc165 chemicals, 3 rings![Scaffold c1ccc2c3c([nH]c2c1)CNCC3](/scaffold/CFTOTSJVQRFXOF-UHFFFAOYSA-N/structure.svg)
Tetrahydro-beta-carboline65 chemicals, 3 rings![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
N-Phenyl-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide65 chemicals, 2 rings![Scaffold c1ccc(Cc2nc3ccccc3[nH]2)cc1](/scaffold/YTLQFZVCLXFFRK-UHFFFAOYSA-N/structure.svg)
Bendazol65 chemicals, 3 rings
1,3,4-Oxadiazole, 2-5-diphenyl-64 chemicals, 3 rings
O=C1CCCC2=C1C(c1ccccc1)C(C(=O)Nc1ccccn1)=CN264 chemicals, 4 rings
N-Phenyl-1-benzofuran-2-carboxamide64 chemicals, 3 rings
3-Phenylpyrazolo[1,5-a]pyrimidine64 chemicals, 3 rings
O=c1c(=Cc2ccccc2)sc2n1C(c1ccccc1)C=CN=264 chemicals, 4 rings
2-(2-Naphthyl)-5-phenyl-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine64 chemicals, 6 rings
2H-Benzotriazole, 2-phenyl-64 chemicals, 3 rings
N-Cyclohexylbenzenesulfonamide64 chemicals, 2 rings
C1=CC2C3Cc4cccc5c4C2(CCN3)C(C1)O563 chemicals, 5 rings![Scaffold c1n[nH]cc1B1OCCO1](/scaffold/BMQOPKIAPDKYOJ-UHFFFAOYSA-N/structure.svg)
c1n[nH]cc1B1OCCO163 chemicals, 2 rings
O=C1C=CC2C(=O)C3=Cc4ccccc4CC3CC2C163 chemicals, 4 rings
2-Cyclopropylpyrimidine63 chemicals, 2 rings
1H-Pyrrole, 1-(phenylmethyl)-63 chemicals, 2 rings
Spiro(2,5)octane63 chemicals, 2 rings
Phenyl 2-phenylquinoline-4-carboxylate63 chemicals, 4 rings
3-(2-Oxo-2-phenylethyl)indolin-2-one63 chemicals, 3 rings
4-Phenoxypiperidine63 chemicals, 2 rings
O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1Cc1ccccc163 chemicals, 5 rings
O=C1C(N=Nc2ccccc2)C=NN1c1ccccc163 chemicals, 3 rings![Scaffold c1ccc(-c2c[nH]nc2-c2ccccc2)cc1](/scaffold/MQWYZELNDPRANJ-UHFFFAOYSA-N/structure.svg)
3,4-Diphenylpyrazole63 chemicals, 3 rings
6-Aza-spiro[3.4]octane63 chemicals, 2 rings
2-Benzylsulfanyl-3-phenylquinazolin-4-one63 chemicals, 4 rings
3,5-Diphenyl-1,2,4-oxadiazole63 chemicals, 3 rings
1,10-Phenanthroline62 chemicals, 3 rings
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-phenylacetamide62 chemicals, 3 rings
O=C(COc1ccccc1)NN=Cc1ccccc1OC(=O)c1ccccc162 chemicals, 3 rings
3-Phenylpiperidine62 chemicals, 2 rings
4,5,6,7-Tetrahydropyrazolo(1,5-a)pyrazine62 chemicals, 2 rings![Scaffold c1cc2nc[nH]c2cn1](/scaffold/UBOOKRVGOBKDMM-UHFFFAOYSA-N/structure.svg)
1H-Imidazo(4,5-c)pyridine62 chemicals, 2 rings
2-Morpholinopyridine62 chemicals, 2 rings
7-Oxabicyclo(2.2.1)heptane62 chemicals, 2 rings
N-(4-Thiazolin-2-ylidene)benzenesulfonamide61 chemicals, 2 rings
Benzenesulfonic acid, phenyl ester61 chemicals, 2 rings![Scaffold O=C(Nc1ccccc1)c1cc2ccccc2[nH]c1=O](/scaffold/DZOOMZBMCVCDDF-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc2ccccc2[nH]c1=O61 chemicals, 3 rings
Methanone, phenyl(1-phenyl-1H-pyrazol-4-yl)-61 chemicals, 3 rings
Decalin61 chemicals, 2 rings
Quinuclidine61 chemicals, 3 rings
Benzyl piperidine-1-carboxylate61 chemicals, 2 rings
O=C(NN=Cc1ccccc1)c1ccncc161 chemicals, 2 rings
Piperidyl formanilide61 chemicals, 2 rings
Phenylmethyl 1-pyrrolidinecarboxylate61 chemicals, 2 rings
Bicyclo(4.1.0)heptane61 chemicals, 2 rings
1-Benzyl-1,2,3,4-tetrahydroisoquinoline61 chemicals, 3 rings
1-Benzenesulfonylpyrazole60 chemicals, 2 rings
N-Phenylnaphthalene-2-carboxamide60 chemicals, 3 rings
4(3H)-Quinazolinone, 3-(phenylmethyl)-60 chemicals, 3 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]1](/scaffold/IKNFCGLJTJPKTB-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]160 chemicals, 4 rings