Murcko scaffold
6-Oxa-2-azaspiro[3.4]octane scaffold
87 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 87
- With full pages
- 10
Scaffold SMILES
C1CC2(CNC2)CO1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 87 of 87 chemicals
![tert-Butyl 7-(hydroxymethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H21NO4, CAS 2413878-10-9](/s/VNNWYCJUTNYKTN-UHFFFAOYSA-N.svg)
tert-Butyl 7-(hydroxymethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2413878-10-9C12H21NO4
![7,7-Dimethyl-6-oxa-2-azaspiro[3.4]octane chemical structure, C8H15NO, CAS 2166815-02-5](/s/HNHBNDORSOOCNU-UHFFFAOYSA-N.svg)
7,7-Dimethyl-6-oxa-2-azaspiro[3.4]octane
CAS 2166815-02-5C8H15NO
![Ethyl 2-{6-oxa-2-azaspiro[3.4]octan-7-yl}acetate chemical structure, C10H17NO3, CAS 2138332-55-3](/s/OPUCXDGINOZUBI-UHFFFAOYSA-N.svg)
Ethyl 2-{6-oxa-2-azaspiro[3.4]octan-7-yl}acetate
CAS 2138332-55-3C10H17NO3
![2-{6-Oxa-2-azaspiro[3.4]octan-7-yl}acetic acid chemical structure, C8H13NO3, CAS 2137885-57-3](/s/ZLOVYXJQCRLAFV-UHFFFAOYSA-N.svg)
2-{6-Oxa-2-azaspiro[3.4]octan-7-yl}acetic acid
CAS 2137885-57-3C8H13NO3
![7,7-Dimethyl-6-oxa-2-azaspiro[3.4]octane hydrochloride chemical structure, C8H16ClNO, CAS 2770359-00-5](/s/JOXMIFCPEVMXFD-UHFFFAOYSA-N.svg)
7,7-Dimethyl-6-oxa-2-azaspiro[3.4]octane hydrochloride
CAS 2770359-00-5C8H16ClNO
![tert-Butyl 5-(azidomethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H20N4O3, CAS 2171835-68-8](/s/SCNDSQKUPFEBKB-UHFFFAOYSA-N.svg)
tert-Butyl 5-(azidomethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2171835-68-8C12H20N4O3
![5-(Azidomethyl)-6-oxa-2-azaspiro[3.4]octane chemical structure, C7H12N4O, CAS 2167784-76-9](/s/UOMQIAMWVDROAM-UHFFFAOYSA-N.svg)
5-(Azidomethyl)-6-oxa-2-azaspiro[3.4]octane
CAS 2167784-76-9C7H12N4O
![tert-Butyl 5-(aminomethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H22N2O3, CAS 2167356-14-9](/s/JXWAJNHMLLBZNH-UHFFFAOYSA-N.svg)
tert-Butyl 5-(aminomethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2167356-14-9C12H22N2O3
![6-Oxa-2-azaspiro[3.4]octane-2-carboxamide chemical structure, C7H12N2O2, CAS 2408974-83-2](/s/MNDFHVNKPNRZEH-UHFFFAOYSA-N.svg)
6-Oxa-2-azaspiro[3.4]octane-2-carboxamide
CAS 2408974-83-2C7H12N2O2
![{6-Oxa-2-azaspiro[3.4]octan-5-yl}methanesulfonyl fluoride chemical structure, C7H12FNO3S, CAS 2169581-15-9](/s/NYHQJXATWOTCGR-UHFFFAOYSA-N.svg)
{6-Oxa-2-azaspiro[3.4]octan-5-yl}methanesulfonyl fluoride
CAS 2169581-15-9C7H12FNO3S
![N-Ethyl-N-(2-{6-oxa-2-azaspiro[3.4]octan-2-yl}-2-oxoethyl)prop-2-enamide chemical structure, C13H20N2O3, CAS 2411308-88-6](/s/PNKJTLRWXLNNED-UHFFFAOYSA-N.svg)
N-Ethyl-N-(2-{6-oxa-2-azaspiro[3.4]octan-2-yl}-2-oxoethyl)prop-2-enamide
CAS 2411308-88-6C13H20N2O3
![tert-Butyl N-({6-oxa-2-azaspiro[3.4]octan-7-yl}methyl)carbamate chemical structure, C12H22N2O3, CAS 2825006-76-4](/s/WXCXVSXCXXEESK-UHFFFAOYSA-N.svg)
tert-Butyl N-({6-oxa-2-azaspiro[3.4]octan-7-yl}methyl)carbamate
CAS 2825006-76-4C12H22N2O3
![tert-Butyl 2-{6-oxa-2-azaspiro[3.4]octan-7-yl}acetate chemical structure, C12H21NO3, CAS 2138512-64-6](/s/HRDGNAMPBHNUBM-UHFFFAOYSA-N.svg)
tert-Butyl 2-{6-oxa-2-azaspiro[3.4]octan-7-yl}acetate
CAS 2138512-64-6C12H21NO3
![Methyl 2-{6-oxa-2-azaspiro[3.4]octan-7-yl}acetate chemical structure, C9H15NO3, CAS 2137577-86-5](/s/WNFOMPZIEDMYHM-UHFFFAOYSA-N.svg)
Methyl 2-{6-oxa-2-azaspiro[3.4]octan-7-yl}acetate
CAS 2137577-86-5C9H15NO3
![tert-Butyl 5-(sulfamoylmethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H22N2O5S, CAS 2171842-38-7](/s/WKPJACMAMUEKDK-UHFFFAOYSA-N.svg)
tert-Butyl 5-(sulfamoylmethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2171842-38-7C12H22N2O5S
![1-{6-Oxa-2-azaspiro[3.4]octan-5-yl}methanamine chemical structure, C7H14N2O, CAS 2166952-61-8](/s/SXNONBLRRDADSY-UHFFFAOYSA-N.svg)
1-{6-Oxa-2-azaspiro[3.4]octan-5-yl}methanamine
CAS 2166952-61-8C7H14N2O
![{6-Oxa-2-azaspiro[3.4]octan-5-yl}methanesulfonamide chemical structure, C7H14N2O3S, CAS 2167442-86-4](/s/OGQNIFDGBGVZHD-UHFFFAOYSA-N.svg)
{6-Oxa-2-azaspiro[3.4]octan-5-yl}methanesulfonamide
CAS 2167442-86-4C7H14N2O3S
![tert-Butyl 5-[(fluorosulfonyl)methyl]-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H20FNO5S, CAS 2172143-55-2](/s/IQBZHCHFZFPUEN-UHFFFAOYSA-N.svg)
tert-Butyl 5-[(fluorosulfonyl)methyl]-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2172143-55-2C12H20FNO5S
![tert-Butyl 7-(sulfamoylmethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H22N2O5S, CAS 2283337-96-0](/s/ZZGQEOJRKYSPHK-UHFFFAOYSA-N.svg)
tert-Butyl 7-(sulfamoylmethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2283337-96-0C12H22N2O5S
![tert-Butyl 6-oxa-2-azaspiro[3.4]octane-7-carboxylate chemical structure, C11H19NO3, CAS 2580216-07-3](/s/CPNMLMDRLLIOAY-UHFFFAOYSA-N.svg)
tert-Butyl 6-oxa-2-azaspiro[3.4]octane-7-carboxylate
CAS 2580216-07-3C11H19NO3
![6-Oxa-2-azaspiro[3.4]octane-7-carboxylic acid chemical structure, C7H11NO3, CAS 2580217-66-7](/s/PGUQEXSWRPZODJ-UHFFFAOYSA-N.svg)
6-Oxa-2-azaspiro[3.4]octane-7-carboxylic acid
CAS 2580217-66-7C7H11NO3
![Ethyl 6-oxa-2-azaspiro[3.4]octane-7-carboxylate chemical structure, C9H15NO3, CAS 2580243-72-5](/s/QFMKGLMSSPYIPZ-UHFFFAOYSA-N.svg)
Ethyl 6-oxa-2-azaspiro[3.4]octane-7-carboxylate
CAS 2580243-72-5C9H15NO3
![2-{2-Acetyl-6-oxa-2-azaspiro[3.4]octan-7-yl}acetic acid chemical structure, C10H15NO4, CAS 2680699-74-3](/s/KUEMRVUNCSWBMY-UHFFFAOYSA-N.svg)
2-{2-Acetyl-6-oxa-2-azaspiro[3.4]octan-7-yl}acetic acid
CAS 2680699-74-3C10H15NO4
![2-[2-(2,2,2-Trifluoroacetyl)-6-oxa-2-azaspiro[3.4]octan-7-yl]acetic acid chemical structure, C10H12F3NO4, CAS 2680702-79-6](/s/PCAYJTXPLGZZOP-UHFFFAOYSA-N.svg)
2-[2-(2,2,2-Trifluoroacetyl)-6-oxa-2-azaspiro[3.4]octan-7-yl]acetic acid
CAS 2680702-79-6C10H12F3NO4
- 2-{2-[(Prop-2-en-1-yloxy)carbonyl]-6-oxa-2-azaspiro[3.4]octan-7-yl}acetic acid2680801-48-1C12H17NO5
- 5-(Iodomethyl)-6-oxa-2-azaspiro[3.4]octane2169060-24-4C7H12INO
- 2-Acetyl-6-oxa-2-azaspiro[3.4]octane-7-carboxylic acid2920143-71-9C9H13NO4
- 2-(2,2,2-Trifluoroacetyl)-6-oxa-2-azaspiro[3.4]octane-7-carboxylic acid2920129-92-4C9H10F3NO4
- 2-[(Prop-2-en-1-yloxy)carbonyl]-6-oxa-2-azaspiro[3.4]octane-7-carboxylic acid2920154-82-9C11H15NO5
- (R)-6-Oxa-2-azaspiro[3.4]octan-8-amine dihydrochloride2306252-44-6C6H14Cl2N2O
- (R)-6-Oxa-2-azaspiro[3.4]octan-8-amine2306252-43-5C6H12N2O
- (S)-6-Oxa-2-azaspiro[3.4]octane-8-carboxylic acid2306254-92-0C7H11NO3
- Methyl 6-oxa-2-azaspiro[3.4]octane-7-carboxylate, trifluoroacetic acid2995279-88-2C10H14F3NO5
- 6-Oxa-2-azaspiro[3.4]octane-7-carboxylic acid, trifluoroacetic acid2995279-20-2C9H12F3NO5
- 8-Fluoro-6-oxa-2-azaspiro[3.4]octane2925068-28-4C6H10FNO
- (8R)-6-Oxa-2-azaspiro[3.4]octane-8-carboxylic acid2306250-09-7C7H11NO3
- 8,8-Difluoro-6-oxa-2-azaspiro[3.4]octane2925067-97-4C6H9F2NO
- 2-[(tert-Butoxy)carbonyl]-6-oxa-2-azaspiro[3.4]octane-5-carboxylic acid2955551-92-3C12H19NO5
- tert-Butyl 7-(aminomethyl)-7-methyl-6-oxa-2-azaspiro[3.4]octane-2-carboxylate3028186-95-7C13H24N2O3
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1CNC2(C1)CCC232 chemicals
C1COC2(C1)CNC230 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals
O=C1CC2(CCC2)CN17 chemicals