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Murcko scaffold

1-Benzoyl-4-phenylpiperazine scaffold

844 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
844
With full pages
177
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzoyl-4-phenylpiperazine page
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 145 to 192 of 844 chemicals

(4-(4-Aminophenyl)piperazin-1-yl)(4-chlorophenyl)methanone chemical structure, C17H18ClN3O, CAS 585567-84-6
(4-(4-Aminophenyl)piperazin-1-yl)(4-chlorophenyl)methanone
CAS 585567-84-6C17H18ClN3O
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(4-nitrophenyl)methanone chemical structure, C19H21N3O3, CAS 349613-95-2
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(4-nitrophenyl)methanone
CAS 349613-95-2C19H21N3O3
(2-Chlorophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C19H21ClN2O, CAS 349615-41-4
(2-Chlorophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 349615-41-4C19H21ClN2O
(3-Chlorophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C19H21ClN2O, CAS 349611-61-6
(3-Chlorophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 349611-61-6C19H21ClN2O
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(2-fluorophenyl)methanone chemical structure, C19H21FN2O, CAS 349612-16-4
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(2-fluorophenyl)methanone
CAS 349612-16-4C19H21FN2O
(3,4-Dimethylphenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C21H26N2O, CAS 349618-83-3
(3,4-Dimethylphenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 349618-83-3C21H26N2O
1-(2,3-Dimethylphenyl)-4-(4-methoxybenzoyl)piperazine chemical structure, C20H24N2O2, CAS 346725-95-9
1-(2,3-Dimethylphenyl)-4-(4-methoxybenzoyl)piperazine
CAS 346725-95-9C20H24N2O2
(2-Chloro-4-methylphenyl)-(4-phenylpiperazin-1-yl)methanone chemical structure, C18H19ClN2O, CAS 430455-55-3
(2-Chloro-4-methylphenyl)-(4-phenylpiperazin-1-yl)methanone
CAS 430455-55-3C18H19ClN2O
[4-(4-Fluorophenyl)piperazin-1-yl]-(4-propan-2-ylphenyl)methanone chemical structure, C20H23FN2O, CAS 543722-38-9
[4-(4-Fluorophenyl)piperazin-1-yl]-(4-propan-2-ylphenyl)methanone
CAS 543722-38-9C20H23FN2O
[4-(4-Fluorophenyl)piperazin-1-yl]-(3-methyl-2-nitrophenyl)methanone chemical structure, C18H18FN3O3, CAS 600126-89-4
[4-(4-Fluorophenyl)piperazin-1-yl]-(3-methyl-2-nitrophenyl)methanone
CAS 600126-89-4C18H18FN3O3
4-(3,4-Dimethylphenyl)piperazinyl 4-nitrophenyl ketone chemical structure, C19H21N3O3, CAS 501104-21-8
4-(3,4-Dimethylphenyl)piperazinyl 4-nitrophenyl ketone
CAS 501104-21-8C19H21N3O3
(3-Methyl-2-nitrophenyl)-(4-phenylpiperazin-1-yl)methanone chemical structure, C18H19N3O3, CAS 600126-61-2
(3-Methyl-2-nitrophenyl)-(4-phenylpiperazin-1-yl)methanone
CAS 600126-61-2C18H19N3O3
[4-(2-Fluorophenyl)piperazin-1-yl]-(3-methyl-2-nitrophenyl)methanone chemical structure, C18H18FN3O3, CAS 600128-92-5
[4-(2-Fluorophenyl)piperazin-1-yl]-(3-methyl-2-nitrophenyl)methanone
CAS 600128-92-5C18H18FN3O3
1-(2,4-Dimethylphenyl)-4-(3-methylbenzoyl)piperazine chemical structure, C20H24N2O, CAS 693229-02-6
1-(2,4-Dimethylphenyl)-4-(3-methylbenzoyl)piperazine
CAS 693229-02-6C20H24N2O
1-Benzoyl-4-(2,4-dimethylphenyl)piperazine chemical structure, C19H22N2O, CAS 693253-67-7
1-Benzoyl-4-(2,4-dimethylphenyl)piperazine
CAS 693253-67-7C19H22N2O
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(4-methoxyphenyl)methanone chemical structure, C19H21ClN2O2, CAS 664319-52-2
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(4-methoxyphenyl)methanone
CAS 664319-52-2C19H21ClN2O2
1-(4-Chlorobenzoyl)-4-(4-chlorophenyl)piperazine chemical structure, C17H16Cl2N2O, CAS 353770-51-1
1-(4-Chlorobenzoyl)-4-(4-chlorophenyl)piperazine
CAS 353770-51-1C17H16Cl2N2O
(2-Chlorophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H21ClN2O2, CAS 543693-76-1
(2-Chlorophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 543693-76-1C19H21ClN2O2
1-Benzoyl-4-(2-ethoxyphenyl)piperazine chemical structure, C19H22N2O2, CAS 353768-49-7
1-Benzoyl-4-(2-ethoxyphenyl)piperazine
CAS 353768-49-7C19H22N2O2
1-(3-Chlorophenyl)-4-(4-isopropylbenzoyl)piperazine chemical structure, C20H23ClN2O, CAS 543715-24-8
1-(3-Chlorophenyl)-4-(4-isopropylbenzoyl)piperazine
CAS 543715-24-8C20H23ClN2O
[4-(4-Chlorophenyl)piperazin-1-yl]-(4-nitrophenyl)methanone chemical structure, C17H16ClN3O3, CAS 79834-42-7
[4-(4-Chlorophenyl)piperazin-1-yl]-(4-nitrophenyl)methanone
CAS 79834-42-7C17H16ClN3O3
1-(3-Fluorobenzoyl)-4-(2-fluorophenyl)piperazine chemical structure, C17H16F2N2O, CAS 494858-46-7
1-(3-Fluorobenzoyl)-4-(2-fluorophenyl)piperazine
CAS 494858-46-7C17H16F2N2O
1-(2,3-Dimethoxybenzoyl)-4-phenylpiperazine chemical structure, C19H22N2O3, CAS 887459-35-0
1-(2,3-Dimethoxybenzoyl)-4-phenylpiperazine
CAS 887459-35-0C19H22N2O3
(3,5-Dimethylphenyl)(4-phenylpiperazin-1-yl)methanone chemical structure, C19H22N2O, CAS 701221-20-7
(3,5-Dimethylphenyl)(4-phenylpiperazin-1-yl)methanone
CAS 701221-20-7C19H22N2O