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Murcko scaffold

1-Benzoyl-4-phenylpiperazine scaffold

844 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
844
With full pages
177
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzoyl-4-phenylpiperazine page
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 193 to 240 of 844 chemicals

(3,4-Dimethoxyphenyl)(4-(3,5-dimethylphenyl)piperazin-1-yl)methanone chemical structure, C21H26N2O3, CAS 667892-36-6
(3,4-Dimethoxyphenyl)(4-(3,5-dimethylphenyl)piperazin-1-yl)methanone
CAS 667892-36-6C21H26N2O3
1-(4-tert-Butylbenzoyl)-4-(2,4-dimethylphenyl)piperazine chemical structure, C23H30N2O, CAS 667893-02-9
1-(4-tert-Butylbenzoyl)-4-(2,4-dimethylphenyl)piperazine
CAS 667893-02-9C23H30N2O
(3,4-Dichlorophenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C18H18Cl2N2O2, CAS 21057-31-8
(3,4-Dichlorophenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 21057-31-8C18H18Cl2N2O2
[4-(3-Chlorophenyl)piperazin-1-yl]-(3-methyl-4-nitrophenyl)methanone chemical structure, C18H18ClN3O3, CAS 331987-18-9
[4-(3-Chlorophenyl)piperazin-1-yl]-(3-methyl-4-nitrophenyl)methanone
CAS 331987-18-9C18H18ClN3O3
4-Nitrophenyl 4-[3-(trifluoromethyl)phenyl]piperazinyl ketone chemical structure, C18H16F3N3O3, CAS 432538-57-3
4-Nitrophenyl 4-[3-(trifluoromethyl)phenyl]piperazinyl ketone
CAS 432538-57-3C18H16F3N3O3
(2,3-Dimethoxyphenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H24N2O4, CAS 524925-58-4
(2,3-Dimethoxyphenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 524925-58-4C20H24N2O4
(5-Chloro-2-methoxyphenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H21ClN2O3, CAS 349434-62-4
(5-Chloro-2-methoxyphenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 349434-62-4C19H21ClN2O3
[4-(2-Ethoxyphenyl)piperazin-1-yl]-(3,4,5-triethoxyphenyl)methanone chemical structure, C25H34N2O5, CAS 544465-86-3
[4-(2-Ethoxyphenyl)piperazin-1-yl]-(3,4,5-triethoxyphenyl)methanone
CAS 544465-86-3C25H34N2O5
(4-Bromophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H21BrN2O2, CAS 560099-74-3
(4-Bromophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 560099-74-3C19H21BrN2O2
(4-tert-Butylphenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C23H30N2O2, CAS 545349-44-8
(4-tert-Butylphenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 545349-44-8C23H30N2O2
(5-Chloro-2-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C18H15ClF3N3O3, CAS 547703-80-0
(5-Chloro-2-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 547703-80-0C18H15ClF3N3O3
(4-Chloro-3-nitrophenyl)(4-(4-fluorophenyl)piperazin-1-yl)methanone chemical structure, C17H15ClFN3O3, CAS 330466-37-0
(4-Chloro-3-nitrophenyl)(4-(4-fluorophenyl)piperazin-1-yl)methanone
CAS 330466-37-0C17H15ClFN3O3
N-[4-[4-(5-Chloro-2-methylphenyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide chemical structure, C20H24ClN3O3S, CAS 641596-54-5
N-[4-[4-(5-Chloro-2-methylphenyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide
CAS 641596-54-5C20H24ClN3O3S
N-[4-[4-(4-Methoxyphenyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide chemical structure, C20H25N3O4S, CAS 640717-88-0
N-[4-[4-(4-Methoxyphenyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide
CAS 640717-88-0C20H25N3O4S
(2-Bromophenyl)(4-(4-chlorophenyl)piperazin-1-yl)methanone chemical structure, C17H16BrClN2O, CAS 353788-48-4
(2-Bromophenyl)(4-(4-chlorophenyl)piperazin-1-yl)methanone
CAS 353788-48-4C17H16BrClN2O
1-(5-Chloro-2-methoxybenzoyl)-4-(3-chlorophenyl)piperazine chemical structure, C18H18Cl2N2O2, CAS 349086-46-0
1-(5-Chloro-2-methoxybenzoyl)-4-(3-chlorophenyl)piperazine
CAS 349086-46-0C18H18Cl2N2O2
(2,5-Dichlorophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C18H15Cl2F3N2O, CAS 353790-20-2
(2,5-Dichlorophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 353790-20-2C18H15Cl2F3N2O
1-(4-Chlorophenyl)-4-(2,4-dimethoxybenzoyl)piperazine chemical structure, C19H21ClN2O3, CAS 544432-09-9
1-(4-Chlorophenyl)-4-(2,4-dimethoxybenzoyl)piperazine
CAS 544432-09-9C19H21ClN2O3
1-(4-Ethoxybenzoyl)-4-(2-ethoxyphenyl)piperazine chemical structure, C21H26N2O3, CAS 438467-14-2
1-(4-Ethoxybenzoyl)-4-(2-ethoxyphenyl)piperazine
CAS 438467-14-2C21H26N2O3
(3,4-Dimethylphenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C20H21F3N2O, CAS 432540-69-7
(3,4-Dimethylphenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 432540-69-7C20H21F3N2O
Methyl 3-[4-(3-chlorophenyl)piperazine-1-carbonyl]-5-nitrobenzoate chemical structure, C19H18ClN3O5, CAS 329931-88-6
Methyl 3-[4-(3-chlorophenyl)piperazine-1-carbonyl]-5-nitrobenzoate
CAS 329931-88-6C19H18ClN3O5
2,2-Dimethyl-N-[4-[4-(4-methylbenzoyl)piperazin-1-yl]phenyl]propanamide chemical structure, C23H29N3O2, CAS 642417-17-2
2,2-Dimethyl-N-[4-[4-(4-methylbenzoyl)piperazin-1-yl]phenyl]propanamide
CAS 642417-17-2C23H29N3O2
N-[2-[4-(4-Fluorophenyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide chemical structure, C19H22FN3O3S, CAS 706772-66-9
N-[2-[4-(4-Fluorophenyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide
CAS 706772-66-9C19H22FN3O3S
1-(3,5-Dimethoxybenzoyl)-4-(2-ethoxyphenyl)piperazine chemical structure, C21H26N2O4, CAS 354550-09-7
1-(3,5-Dimethoxybenzoyl)-4-(2-ethoxyphenyl)piperazine
CAS 354550-09-7C21H26N2O4