Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,141 to 1,200 of 15,838 scaffolds
Octahydro-1H-indole26 chemicals, 2 rings![Scaffold O=C1CCCc2c1[nH]c1ccccc21](/scaffold/PDZIFGIQUYFQGK-UHFFFAOYSA-N/structure.svg)
2,3,4,9-Tetrahydro-1H-carbazol-1-one26 chemicals, 3 rings
1,1-Dibenzyl-3-phenylurea26 chemicals, 3 rings
5-Oxaspiro[3.5]nonane26 chemicals, 2 rings
N-{[3-(Benzenesulfonyl)-1,3-oxazolidin-2-yl]methyl}-N'-(2-phenylethyl)ethanediamide26 chemicals, 3 rings
6,7-Dihydro-5H-2-pyrindine26 chemicals, 2 rings
4-Cyclopropylpyrimidine26 chemicals, 2 rings
6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine26 chemicals, 2 rings
1-Benzyl-4-piperidone26 chemicals, 2 rings![Scaffold O=C(CSc1nnc(CNc2ccccc2)[nH]1)Nc1ccccc1](/scaffold/SMIVSWPAFOMGCX-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(CNc2ccccc2)[nH]1)Nc1ccccc126 chemicals, 3 rings
O=C1C=CC(c2ccccc2)N1c1ccccc126 chemicals, 3 rings
2-Phenyloxane26 chemicals, 2 rings
2-Phenyloxolane26 chemicals, 2 rings![Scaffold c1ccc(CSc2ncnc3nc[nH]c23)cc1](/scaffold/ULIQGBPQLPCTAJ-UHFFFAOYSA-N/structure.svg)
6-((Phenylmethyl)thio)-9H-purine26 chemicals, 3 rings
Piperazine, 1-benzoyl-4-piperonyl-26 chemicals, 4 rings
3-Benzylpyridine26 chemicals, 2 rings![Scaffold c1ccc(Nc2ncnc3[nH]cnc23)cc1](/scaffold/WCZNSRQVTJYMRQ-UHFFFAOYSA-N/structure.svg)
N-Purin-6-ylaniline26 chemicals, 3 rings
c1ccc(C2OCc3ccccc32)cc126 chemicals, 3 rings
Thiochroman26 chemicals, 2 rings
c1ccc(-c2csc3ncncc23)cc126 chemicals, 3 rings![Scaffold c1ccc(-c2c[nH]c3ccccc23)cc1](/scaffold/XZNGTBLWFCRXKR-UHFFFAOYSA-N/structure.svg)
3-Phenylindole26 chemicals, 3 rings![Scaffold C1=Cc2nc1c(-c1ccccc1)c1ccc([nH]1)c(-c1ccccc1)c1nc(c(-c3ccccc3)c3ccc([nH]3)c2-c2ccccc2)C=C1](/scaffold/YNHJECZULSZAQK-UHFFFAOYSA-N/structure.svg)
Tetraphenylporphyrin26 chemicals, 9 rings
1,4-Dianilinoanthraquinone26 chemicals, 5 rings
2-Benzyl-1,3-thiazole25 chemicals, 2 rings
C1CCC(OC2CCC(OC3CCCOC3)OC2)OC125 chemicals, 3 rings
2-Phenylphthalazin-1(2H)-one25 chemicals, 3 rings
2,3-Dihydroquinolin-4(1H)-one25 chemicals, 2 rings
2-Oxa-5-azabicyclo(2.2.1)heptane25 chemicals, 2 rings
6-Phenylpiperidin-2-one25 chemicals, 2 rings![Scaffold c1cc2sccc2[nH]1](/scaffold/DWAIOCIOSRZZHO-UHFFFAOYSA-N/structure.svg)
Thienopyrrole25 chemicals, 2 rings![Scaffold O=c1[nH][nH]cc1C=Nc1ccccc1](/scaffold/FERJRLXXQYDYPG-UHFFFAOYSA-N/structure.svg)
O=c1[nH][nH]cc1C=Nc1ccccc125 chemicals, 2 rings![Scaffold S=c1[nH]c2ccccc2o1](/scaffold/FLFWJIBUZQARMD-UHFFFAOYSA-N/structure.svg)
2-Mercaptobenzoxazole25 chemicals, 2 rings
N-Phenylpicolinamide25 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2c(nc3n2CCCN3Cc2ccccc2)[nH]1](/scaffold/GVZVIHNGZFFQSO-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc3n2CCCN3Cc2ccccc2)[nH]125 chemicals, 4 rings
N-Phenyl-2-pyrimidin-2-ylsulfanylacetamide25 chemicals, 2 rings
C=C1CCC2CCCCC2C125 chemicals, 2 rings
Nicotinic acid benzylamide25 chemicals, 2 rings
1,3-Benzenedicarboxamide, N,N'-diphenyl-25 chemicals, 3 rings
C1=C2C3CCCC3CCC2C2CCCCC2C125 chemicals, 4 rings
C(=Cc1ccccc1)C1=Nc2ccccc2C125 chemicals, 3 rings
2-(Benzylthio)-1-(phenylsulfonyl)-4,5-dihydro-1H-imidazole25 chemicals, 3 rings
C=C1CCCC(=O)OCC2=CCN3CCC(OC1=O)C2325 chemicals, 3 rings
Pyrazine, 2-phenyl-25 chemicals, 2 rings
Bicyclo(3.2.1)octane25 chemicals, 2 rings
1,2,3,4-Tetrahydro-1,1'-biphenyl25 chemicals, 2 rings
2,3,4,5-Tetrahydro-1H-1-benzazepine25 chemicals, 2 rings
3-Aza-bicyclo[4.1.0]heptane25 chemicals, 2 rings
Decahydroisoquinoline25 chemicals, 2 rings
Dechloroclotrimazole25 chemicals, 4 rings![Scaffold O=c1cc(-c2ccccc2)nc[nH]1](/scaffold/OATNBMJACLEOTB-UHFFFAOYSA-N/structure.svg)
6-Phenylpyrimidin-4-ol25 chemicals, 2 ringsOc1ccccc1](/scaffold/OGBPILLJZSJJRC-UHFFFAOYSA-N/structure.svg)
Diphenyl phosphite25 chemicals, 2 rings![Scaffold c1ccc(CSc2nnc(-c3cccnc3)[nH]2)cc1](/scaffold/OUELDRTWHCTFGU-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3cccnc3)[nH]2)cc125 chemicals, 3 rings![Scaffold O=C(NCc1ccccc1)c1ccc[nH]1](/scaffold/PSYQATYJXPGBDC-UHFFFAOYSA-N/structure.svg)
N-Benzyl-1H-pyrrole-2-carboxamide25 chemicals, 2 rings
c1cc2c3c(c1)OC1CCCC4C(C2)NCCC31425 chemicals, 5 rings
3-(Benzylamino)-1-phenylpyrrolidine-2,5-dione25 chemicals, 3 rings![Scaffold c1ccc(-c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)cc1](/scaffold/RNIPJYFZGXJSDD-UHFFFAOYSA-N/structure.svg)
2,4,5-Triphenylimidazole25 chemicals, 4 rings
2,3-Diphenylquinoxaline25 chemicals, 4 rings![Scaffold O=C1CC(c2nc3ccccc3[nH]2)CN1c1ccccc1](/scaffold/SAWYHQAUXNGBMX-UHFFFAOYSA-N/structure.svg)
4-(1H-Benzimidazol-2-yl)-1-phenylpyrrolidin-2-one25 chemicals, 4 rings
N-(3-(Benzoylamino)phenyl)benzamide25 chemicals, 3 rings
O=C1C(=O)N(Cc2ccncc2)C(c2ccccc2)C1=Cc1ccccc125 chemicals, 4 rings