Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,021 to 1,080 of 15,838 scaffolds
![Scaffold O=c1[nH]cccc1S(=O)(=O)c1ccccc1](/scaffold/DVIKRUROEAVCJS-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cccc1S(=O)(=O)c1ccccc128 chemicals, 2 rings
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(furan-2-ylmethyl)-2-phenoxyacetamide28 chemicals, 3 rings
3-Phenylpyrrolidine-2,5-dione28 chemicals, 2 rings![Scaffold c1ccc(CNc2nc3ccccc3[nH]2)cc1](/scaffold/FXMPPQGQNSTUGE-UHFFFAOYSA-N/structure.svg)
N-Benzyl-1H-1,3-benzodiazol-2-amine28 chemicals, 3 rings
O=C1CC2SCC=CN1228 chemicals, 2 rings
C(=C1CCCc2cc3ccccc3nc21)c1ccccc128 chemicals, 4 rings
C1=CC2CCCC2C(OC2CCCCO2)O128 chemicals, 3 rings
O=C1CSC2=NC=CC(c3ccccc3)N1228 chemicals, 3 rings
2-Phenyl-1-(4-phenylpiperazin-1-yl)ethanone28 chemicals, 3 rings
Imidazolidine, 2-(phenylimino)-28 chemicals, 2 rings
1-Benzyl-1,4-diazepane28 chemicals, 2 rings
O=C(OCc1cccc(Oc2ccccc2)c1)C1CC128 chemicals, 3 rings![Scaffold C1=Cc2cc3ccc(cc4ccc(cc5nc(cc1n2)C=C5)[nH]4)[nH]3](/scaffold/JZRYQZJSTWVBBD-UHFFFAOYSA-N/structure.svg)
Porphyrin28 chemicals, 5 rings![Scaffold c1ccc2c(c1)[nH]c1cc3ccncc3cc12](/scaffold/KSEHRXUCGLUTMA-UHFFFAOYSA-N/structure.svg)
5,11-Didemethylellipticine28 chemicals, 4 rings![Scaffold c1ccc(-c2cc[nH]c2)cc1](/scaffold/LJDRAKFYYGCAQC-UHFFFAOYSA-N/structure.svg)
3-Phenyl-1H-pyrrole28 chemicals, 2 rings
Binap, (A+-)-28 chemicals, 8 rings![Scaffold O=C(NCc1ccccc1)c1cc2ccccc2[nH]c1=O](/scaffold/NFZNYXLYBOKFMQ-UHFFFAOYSA-N/structure.svg)
O=C(NCc1ccccc1)c1cc2ccccc2[nH]c1=O28 chemicals, 3 rings
2,3-Dihydro-1lambda6-benzothiophene-1,1-dione28 chemicals, 2 rings
(1,2,4)Triazolo(4,3-a)pyrazine28 chemicals, 2 rings
O=C(OCC1c2ccccc2-c2ccccc21)N1CCc2ccccc2C128 chemicals, 5 rings
C1CNCC2(C1)CCC228 chemicals, 2 rings
Bicyclopropyl28 chemicals, 2 rings
Cyclopropyl phenyl ketone28 chemicals, 2 rings
1-Phenyl-3-(phenylsulfanyl)propan-1-one28 chemicals, 2 rings
c1ccc(CSc2nnc(-c3ccccc3)n2-c2ccccc2)cc128 chemicals, 4 rings
Thiobarbituric acid28 chemicals, 1 ring
N,4-diphenylpiperazine-1-carboxamide28 chemicals, 3 rings
1-Benzylisatin28 chemicals, 3 rings![Scaffold O=c1cn[nH]c(=O)[nH]1](/scaffold/SSPYSWLZOPCOLO-UHFFFAOYSA-N/structure.svg)
1,2,4-Triazine-3,5(2H,4H)-dione28 chemicals, 1 ring
5H,6H,7H,8H-Pyrido(4,3-d)pyrimidine28 chemicals, 2 rings![Scaffold c1[nH]nc2c1CCC2](/scaffold/TUVBJSPUCMUOSD-UHFFFAOYSA-N/structure.svg)
1,4,5,6-Tetrahydrocyclopenta[c]pyrazole28 chemicals, 2 rings
C1=CC(c2ccccc2)c2cnn(-c3ccccc3)c2O128 chemicals, 4 rings
1-(Oxan-4-yl)-1H-pyrazole28 chemicals, 2 rings
N-Benzylthiophene-2-carboxamide28 chemicals, 2 rings
Benzyl(furan-2-ylmethyl)amine28 chemicals, 2 rings![Scaffold c1ccc(CSc2nnc(-c3ccco3)[nH]2)cc1](/scaffold/WNYOUTZVVXKPLR-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccco3)[nH]2)cc128 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(nc3n2CCCN3c2ccccc2)[nH]1](/scaffold/WWOWWQCAVABTQB-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc3n2CCCN3c2ccccc2)[nH]128 chemicals, 4 rings
N-Benzylpyrimidin-2-amine28 chemicals, 2 rings
11H-Dibenzo(b,e)(1,4)dioxepin-11-one28 chemicals, 3 rings
C1CC2CNC3C4CC2C3(C1)C1CC2CCC4C1C228 chemicals, 6 rings
O=C1CC=CCCCCC2CCCC(O2)C(=O)C(=O)N2CCCCC2C(=O)OC(C=CC2CCCCC2)CCC128 chemicals, 4 rings
N-(Thiophen-3-yl)benzamide28 chemicals, 2 rings
O=C(COc1ccccc1)N(Cc1ccccc1)C1CCS(=O)(=O)C128 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)[nH]c(=O)[nH]1](/scaffold/ZFSLODLOARCGLH-UHFFFAOYSA-N/structure.svg)
Cyanuric acid28 chemicals, 1 ring
2-Phenyl-2-oxazoline28 chemicals, 2 rings![Scaffold O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/ARHCMYOKQKXAGO-UHFFFAOYSA-N/structure.svg)
O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc127 chemicals, 3 rings
2-(1H-Pyrrol-1-yl)pyridine27 chemicals, 2 rings
3,3-Diphenyl-3H-benzo[c][1,2]oxathiole 1,1-dioxide27 chemicals, 4 rings
2-[6-(Furan-2-yl)pyridazin-3-yl]sulfanyl-N-phenylacetamide27 chemicals, 3 rings
4-Benzylpyridine27 chemicals, 2 rings
N-Cyclopentylbenzenesulfonamide27 chemicals, 2 rings
2-Phenylcyclohexanone27 chemicals, 2 rings
2-Benzoylpyridine27 chemicals, 2 rings
2-(1H-Pyrazol-1-yl)pyrimidine27 chemicals, 2 rings
1,4-Diphenylbutane27 chemicals, 2 rings
c1ccc(C2=NCc3nncn3-c3ccccc32)cc127 chemicals, 4 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccs1](/scaffold/IPOYPASHMASOHF-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccs127 chemicals, 3 rings
O=C1OCC2Cc3cc4c(cc3C(c3ccccc3)C12)OCO427 chemicals, 5 rings
1-Phenyl-3-(2-pyridyl)thiourea27 chemicals, 2 rings
3-Cyclopropylisoxazole27 chemicals, 2 rings