Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,201 to 1,260 of 15,838 scaffolds
5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine25 chemicals, 2 rings![Scaffold c1nc2c([nH]1)CNCC2](/scaffold/URMVFILWXLQJIP-UHFFFAOYSA-N/structure.svg)
Spinaceamine25 chemicals, 2 rings
O=C1C=C(C(=O)c2ccco2)C(c2ccccc2)N125 chemicals, 3 rings![Scaffold O=c1[nH]cnc2nccnc12](/scaffold/UWWUXWWWOUNMKW-UHFFFAOYSA-N/structure.svg)
Pteridin-4-ol25 chemicals, 2 rings
Glutaric anhydride25 chemicals, 1 ring
2-Phenylquinazoline25 chemicals, 3 rings
4-Benzal-2-phenyl-5-oxazolone25 chemicals, 3 rings
Thieno(3,2-b)thiophene25 chemicals, 2 rings
Thiophene, 2-(phenylmethyl)-25 chemicals, 2 rings
4-Oxo-N-phenyl-4H-chromene-2-carboxamide25 chemicals, 3 rings
Chrysene25 chemicals, 4 rings
C=C1CCCCC1=CC=C1CCCC2C(CC=CCC3CC3)CCC1225 chemicals, 4 rings
O=C(OCC1c2ccccc2-c2ccccc21)N1CCC125 chemicals, 4 rings
N-(3-Phenylpropyl)benzamide25 chemicals, 2 rings
c1cc(N2CCCC2)ncn125 chemicals, 2 rings
N-Phenylbicyclo[2.2.1]hept-5-ene-2-carboximidic acid25 chemicals, 3 rings
7-(Benzyloxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one25 chemicals, 4 rings
1-Benzyl-1H-indazole25 chemicals, 3 rings![Scaffold c1ccc(-c2nc3ccccc3[nH]2)nc1](/scaffold/YNFBMDWHEHETJW-UHFFFAOYSA-N/structure.svg)
2-(2'-Pyridyl)benzimidazole25 chemicals, 3 rings
3-Phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide25 chemicals, 2 rings
Pyrrolizidine24 chemicals, 2 rings
N-(Thiophen-2-ylmethyl)aniline24 chemicals, 2 rings
N-Phenyl-2-piperidinosuccinimide24 chemicals, 3 rings
Bicyclo(3.2.0)heptane24 chemicals, 2 rings
O=C1C=C(C2CCC3C2CCC2C4CCCCC4CCC23)CO124 chemicals, 5 rings
Benzoic anhydride24 chemicals, 2 rings![Scaffold O=c1c2ccccc2[nH]c(=S)n1-c1ccccc1](/scaffold/CRGOYNYLYMPGKH-UHFFFAOYSA-N/structure.svg)
2-Mercapto-3-phenylquinazolin-4(3H)-one24 chemicals, 3 rings
Phenyl(piperidin-4-yl)methanone24 chemicals, 2 rings
3-Cyclopropylpyrrolidine24 chemicals, 2 rings
1-Cyclohexylpyrazole24 chemicals, 2 rings
1,2,6,7-Tetrahydro-5H-pyrido[3,2,1-ij]quinolin-3-one24 chemicals, 3 rings
5H,6H,7H,8H-Imidazo(1,5-a)pyridine24 chemicals, 2 rings
1-Benzylimidazolidine-2,4,5-trione24 chemicals, 2 rings
Dihydrodicyclopentadiene24 chemicals, 3 rings
Kyaphenine24 chemicals, 4 rings
Benzocycloheptene24 chemicals, 2 rings
O=C1CCCCOC(=O)CC(OC2CCCCO2)CC(OC2CCCCO2)CCC124 chemicals, 3 rings![Scaffold O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2ccccc12](/scaffold/HKRPJNNJPHFLPC-UHFFFAOYSA-N/structure.svg)
O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2ccccc1224 chemicals, 3 rings
5,6,7,8-Tetrahydroisoquinoline24 chemicals, 2 rings
2-Phenyl-N-pyridin-2-ylacetamide24 chemicals, 2 rings
O=c1c(-c2ccccc2)coc2c(CN3CCCCC3)cccc1224 chemicals, 4 rings![Scaffold c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1](/scaffold/INERHEQVAVQJBO-UHFFFAOYSA-N/structure.svg)
1-Phenyl-2,3,4,9-tetrahydro-1H-beta-carboline24 chemicals, 4 rings
1-Phenyl-3-(phenylsulfonyl)propan-1-one24 chemicals, 2 rings
Isocoumarin24 chemicals, 2 rings
N-[2-(Morpholin-4-yl)ethyl]benzenesulfonamide24 chemicals, 2 rings
1-Benzylisoquinoline24 chemicals, 3 rings
Benzo[c]isothiazole24 chemicals, 2 rings![Scaffold c1cncc(-c2cc[nH]n2)c1](/scaffold/JJLMOUMOJSUSSX-UHFFFAOYSA-N/structure.svg)
3-(1H-Pyrazol-5-yl)pyridine24 chemicals, 2 rings
C1CC(C2CC2)C124 chemicals, 2 rings
4-Phenylquinoline24 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(ncn2CCCOc2ccccc2)[nH]1](/scaffold/MNJRUFQRNCGTDR-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(ncn2CCCOc2ccccc2)[nH]124 chemicals, 3 rings
N-(5-Benzyl-1,3-thiazol-2-yl)benzamide24 chemicals, 3 rings
c1ccc(N=Nc2nc3ccccc3s2)cc124 chemicals, 3 rings
3,4-Dihydroisoquinoline24 chemicals, 2 rings
N-Phenylpyrrolidine-2-carboxamide24 chemicals, 2 rings
Cyclo(glycylprolyl)24 chemicals, 2 rings
O=C(Nc1ccccc1)C1CC2CCC1C224 chemicals, 3 rings
1-(2-Phenylethyl)-1H-1,2,4-triazole24 chemicals, 2 rings
N-Phenylmorpholine-4-carbothioamide24 chemicals, 2 rings
N-Benzylcyclopentanamine24 chemicals, 2 rings