Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,081 to 1,140 of 15,838 scaffolds
![Scaffold c1nc2c([nH]1)CCCC2](/scaffold/KAWYASGZISVRAL-UHFFFAOYSA-N/structure.svg)
4,5,6,7-Tetrahydro-1H-benzimidazole27 chemicals, 2 rings
1,2-Dihydronaphthalene27 chemicals, 2 rings![Scaffold O=c1ccn(-c2ccccc2)c(=O)[nH]1](/scaffold/KELXKKNILLDRLS-UHFFFAOYSA-N/structure.svg)
1-Phenyluracil27 chemicals, 2 rings![Scaffold O=C(Nc1ccccc1)c1c[nH]c(-c2ccccc2)c1-c1ccccc1](/scaffold/KPRRSDNZJQBLFA-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1c[nH]c(-c2ccccc2)c1-c1ccccc127 chemicals, 4 rings
N-(Pyrimidin-4-yl)benzenesulfonamide27 chemicals, 2 rings
6-Phenyl-4,5-dihydro-3(2H)-pyridazinone27 chemicals, 2 rings
c1ccc(C2OCC3C(c4ccccc4)OCC23)cc127 chemicals, 4 rings
Dibenz(b,f)azepine27 chemicals, 3 rings
N-[4-(4-Morpholinylsulfonyl)phenyl]benzamide27 chemicals, 3 rings
1-Phenylpyrimidine-2,4,6(1H,3H,5H)-trione27 chemicals, 2 rings
c1ncc(B2OCCO2)cn127 chemicals, 2 rings
2-Azaspiro(4.4)nonane27 chemicals, 2 rings
c1ccc(Cn2ncc3cncnc32)cc127 chemicals, 3 rings
1-(4-Pyridyl)piperazine27 chemicals, 2 rings
O=C(CSc1cccc(-c2ccccc2)n1)Nc1ccccc127 chemicals, 3 rings![Scaffold O=C(CSc1nc2[nH]ncc2c(=O)[nH]1)Nc1ccccc1](/scaffold/PNAFPQXRNDJUPV-UHFFFAOYSA-N/structure.svg)
2-({4-Oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-6-yl}sulfanyl)-N-phenylacetamide27 chemicals, 3 rings
1,2,3,4-Tetrahydro-1-phenylisoquinoline27 chemicals, 3 rings
C(=Cc1ccncc1)c1ccccc127 chemicals, 2 rings
2-Phenyl-2,3-dihydrobenzofuran27 chemicals, 3 rings
3-(Phenoxymethyl)pyridine27 chemicals, 2 rings
1-(3-Phenoxypropyl)-1H-benzo[d]imidazole27 chemicals, 3 rings
2-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-piperidin-1-ylethanone27 chemicals, 3 rings
N-(1,3-Dioxo-2,3-dihydro-1H-isoindol-5-yl)benzamide27 chemicals, 3 rings
1,3,2-Dioxaborolane, 2-(2-thienyl)-27 chemicals, 2 rings
2-Phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one27 chemicals, 3 rings
O=C(NN=Cc1ccccc1OCc1ccccc1)C(=O)Nc1ccccc127 chemicals, 3 rings
Pyroquilon27 chemicals, 3 rings
1-(Phenoxyacetyl)piperazine27 chemicals, 2 rings
N-(Quinolin-8-yl)benzamide27 chemicals, 3 rings![Scaffold O=C(CSc1nc2c([nH]c3ccccc32)c(=O)[nH]1)Nc1ccccc1](/scaffold/YYTSXMLOMLZPPQ-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2c([nH]c3ccccc32)c(=O)[nH]1)Nc1ccccc127 chemicals, 4 rings
2-Methylene-bicyclo(2.2.1)heptane26 chemicals, 2 rings![Scaffold O=c1[nH]c2ccccc2n1Cc1ccccc1](/scaffold/AUGPRLHZAOPVIR-UHFFFAOYSA-N/structure.svg)
1-Benzyl-1H-benzo[d]imidazol-2(3H)-one26 chemicals, 3 rings
[1,3]Thiazolo[4,5-b]pyridine26 chemicals, 2 rings
2-Anilinoacetophenone26 chemicals, 2 rings
O=C(C=Cc1ccccc1)Nc1ccccn126 chemicals, 2 rings![Scaffold c1cncc(-c2nc3ccccc3[nH]2)c1](/scaffold/BOUOQESVDURNSB-UHFFFAOYSA-N/structure.svg)
2-(Pyridin-3-yl)-1H-1,3-benzodiazole26 chemicals, 3 rings
2-(1H-1,2,4-Triazol-1-yl)pyridine26 chemicals, 2 rings
1-Phenyl-1,4-diazepane26 chemicals, 2 rings
3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione26 chemicals, 3 rings
Benz(cd)indol-2(1H)-one26 chemicals, 3 rings
N-(Piperidin-4-yl)benzenesulfonamide26 chemicals, 2 rings
O=c1c2ccccc2nc(C=Cc2ccccc2)n1-c1ccccc126 chemicals, 4 rings
Diazene, 1-naphthalenyl-2-naphthalenyl-26 chemicals, 4 rings
N-Phenoxyacetylpiperidine26 chemicals, 2 rings
O=C1CCCCCCCCCCCC2CCCC(CC(OC3CCCCO3)C=CC=CC=CC=CCCC=CC=CCCCCO1)O226 chemicals, 3 rings
N-Phenyl-4-(pyridin-2-yl)piperazine-1-carbothioamide26 chemicals, 3 rings
N-4-Piperidylbenzamide26 chemicals, 2 rings![Scaffold c1ccc2c3c([nH]c2c1)C1CC2CCCCC2CN1CC3](/scaffold/JUPDIHMJFPDGMY-UHFFFAOYSA-N/structure.svg)
c1ccc2c3c([nH]c2c1)C1CC2CCCCC2CN1CC326 chemicals, 5 rings
2-(2-Thienyl)quinoline26 chemicals, 3 rings![Scaffold O=C(NCCc1c[nH]c2ccccc12)c1ccccc1](/scaffold/KTEDBFKQSUUOQJ-UHFFFAOYSA-N/structure.svg)
N-(2-(1H-Indol-3-yl)ethyl)benzamide26 chemicals, 3 rings![Scaffold c1nnc(C2CC2)[nH]1](/scaffold/KTIRQJGWLMORDV-UHFFFAOYSA-N/structure.svg)
3-Cyclopropyl-1H-1,2,4-triazole26 chemicals, 2 rings
5H-Chromeno(2,3-b)pyridin-5-one26 chemicals, 3 rings
O=C(CNc1ccccc1)NN=Cc1ccccc126 chemicals, 2 rings
1,4-Diphenylpiperazine26 chemicals, 3 rings
O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)NC2=O26 chemicals, 3 rings
O=S(=O)(NC=NCCc1ccccc1)c1ccccc126 chemicals, 2 rings
(2-Phenoxyethyl)(2-phenylethyl)amine26 chemicals, 2 rings![Scaffold O=c1cc(Cc2nncn2-c2ccccc2)[nH]c(=O)[nH]1](/scaffold/NUYPVNXNLJEHMU-UHFFFAOYSA-N/structure.svg)
O=c1cc(Cc2nncn2-c2ccccc2)[nH]c(=O)[nH]126 chemicals, 3 rings![Scaffold c1ccc(-c2nc3cc4nc5ccccc5[nH]c4cc3n2)cc1](/scaffold/OBLOVYRWVBWHCD-UHFFFAOYSA-N/structure.svg)
2-Phenyl-1H-imidazo(4,5-b)phenazine26 chemicals, 5 rings
O=c1cnn2c(=O)c(=Cc3ccccc3)sc2n126 chemicals, 3 rings