Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,881 to 2,940 of 15,838 scaffolds
Dicyclohexylphenylphosphine12 chemicals, 3 rings
1-Phenyl-3-(pyridin-4-ylmethyl)thiourea12 chemicals, 2 rings
4-(Phenoxymethyl)pyridine12 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(CN3CCNCC3)nc2[nH]1](/scaffold/VYLMWONQIVLCSM-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(CN3CCNCC3)nc2[nH]112 chemicals, 3 rings
O=C(COC(=O)c1cccnc1)Nc1ccccc112 chemicals, 2 rings
N-Benzyl-1,3-benzothiazol-2-amine12 chemicals, 3 rings
C=C1CCC2CC1C212 chemicals, 3 rings![Scaffold c1ccc2[nH]c(-c3cscn3)nc2c1](/scaffold/WJCNZQLZVWNLKY-UHFFFAOYSA-N/structure.svg)
Thiabendazole12 chemicals, 3 rings
Tricyclohexylphosphine12 chemicals, 3 rings
C=C(C(=O)NC1C(=O)N2C=CCSC12)c1cscn112 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(nc3n2CC(COc2ccccc2)O3)[nH]1](/scaffold/WSDSVSCCMISFIK-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc3n2CC(COc2ccccc2)O3)[nH]112 chemicals, 4 rings![Scaffold O=c1ccnc(-c2ccccn2)[nH]1](/scaffold/WWOVEPANCBTFIS-UHFFFAOYSA-N/structure.svg)
2-(Pyridin-2-yl)pyrimidin-4(3H)-one12 chemicals, 2 rings
Benzo(h)quinoline12 chemicals, 3 rings
O=C1C=CC2C(=C1)CCC1C3CCCC3CC(=O)C2112 chemicals, 4 rings
O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1CCc1ccccc112 chemicals, 5 rings![Scaffold O=C(Cc1ccc[nH]1)NN=Cc1ccccc1](/scaffold/XCXHYNVYLRCCIP-UHFFFAOYSA-N/structure.svg)
O=C(Cc1ccc[nH]1)NN=Cc1ccccc112 chemicals, 2 rings
O=C1c2ccccc2C(=O)c2c1ccc1c2C(=O)CCC112 chemicals, 4 rings
O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1cc2ccccc2o112 chemicals, 5 rings
Benzenesulfonamide, N-2-benzothiazolyl-12 chemicals, 3 rings
2-(Piperidin-4-yloxy)pyridine12 chemicals, 2 rings
1-Cyclohexylpiperazine12 chemicals, 2 rings
Quipazine12 chemicals, 3 rings![Scaffold O=c1[nH]cnc2cc(-c3ccccc3)sc12](/scaffold/XSAILWORLBSSMS-UHFFFAOYSA-N/structure.svg)
6-Phenyl-3H,4H-thieno[3,2-d]pyrimidin-4-one12 chemicals, 3 rings
1-Azaspiro(3.5)nonane12 chemicals, 2 rings
2-Phenyl-4,5-dihydro-3(2H)-pyridazinone12 chemicals, 2 rings
Phenanthridine, 6-phenyl-12 chemicals, 4 rings
c1ccc(OCc2cn3ccccc3n2)cc112 chemicals, 3 rings
N-Benzyl-2-(4-phenylpiperazin-1-yl)acetamide12 chemicals, 3 rings
Bicyclo(2.2.1)hept-2-ene, 7-oxa-12 chemicals, 2 rings
4,5,6,7-Tetrahydro-1-benzofuran12 chemicals, 2 rings
5-Oxo-1-phenyl-N-(1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxamide12 chemicals, 3 rings
Thieno[2,3-b]thiophene12 chemicals, 2 rings
c1ccc(Cn2ncc3cccnc32)cc112 chemicals, 3 rings
5,6-Diphenyl-1,2,4-triazine12 chemicals, 3 rings
O=S(=O)(NC(Cc1ccccc1)c1ccccc1)c1ccccc112 chemicals, 3 rings
3,4'-Bipyridine12 chemicals, 2 rings![Scaffold O=c1[nH]cccc1N=Nc1ccccc1](/scaffold/YXNARGOGKBZEHR-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cccc1N=Nc1ccccc112 chemicals, 2 rings
9,10-Phenanthrenedione12 chemicals, 3 rings
Quinoline-2,4(1H,3H)-dione12 chemicals, 2 rings
3-(Piperidin-1-ylmethyl)pyridine12 chemicals, 2 rings
4H,6H,7H-Pyrazolo[3,2-c][1,4]oxazine12 chemicals, 2 rings
O=C1c2ccccc2CN1CCc1ccccc112 chemicals, 3 rings
2-Phenoxy-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]acetamide12 chemicals, 3 rings
N-{11-Oxo-1-azatricyclo[6.3.1.0^{4,12}]dodeca-4(12),5,7-trien-6-yl}benzenesulfonamide12 chemicals, 4 rings
O=C(CNc1ccccc1)NCc1ccccc112 chemicals, 2 rings
1-(Phenoxymethyl)-1,2,3,4-tetrahydroisoquinoline12 chemicals, 3 rings
2-(Furan-2-yl)-5-phenyl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine12 chemicals, 5 rings
c1ccc(N=Nc2cccc(N=Nc3ccccc3)c2)cc112 chemicals, 3 rings
Benzo(g)isoquinoline-5,10-dione12 chemicals, 3 rings
N-(1,3-Benzothiazol-2-yl)-2,3-dihydro-1,4-dioxine-5-carboxamide12 chemicals, 3 rings
O=C(COc1ccccc1)N1CCN(c2ccccn2)CC112 chemicals, 3 rings
C1=CC(c2ccco2)C=CN112 chemicals, 2 rings
1-(Pyrrolidin-3-yl)-1H-pyrazole12 chemicals, 2 rings![Scaffold O=c1cc(N2CCOCC2)cn[nH]1](/scaffold/ZWPTWKSYFNUPFR-UHFFFAOYSA-N/structure.svg)
5-(4-Morpholinyl)-3(2H)-pyridazinone12 chemicals, 2 rings
O=C(Nc1ccccc1)c1cnn(-c2ccccc2)c111 chemicals, 3 rings
O=C(COc1ccccc1)NS(=O)(=O)c1ccccc111 chemicals, 2 rings
Homophthalic anhydride11 chemicals, 2 rings
C=C1C(=O)C23CCC4CCCCC4C2CCC1C311 chemicals, 4 rings
1,8-Diazaspiro[4.5]decane11 chemicals, 2 rings
3-Anilino-1lambda~6~-thiolane-1,1-dione11 chemicals, 2 rings