Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,761 to 2,820 of 15,838 scaffolds
![Scaffold O=C(NN=Cc1ccccc1)c1ccc2nc[nH]c2c1](/scaffold/IGPQHSFIKOXHTI-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1ccc2nc[nH]c2c112 chemicals, 3 rings
Imidazo[5,1-b]thiazole12 chemicals, 2 rings
C(=Cc1ccc(C=Cc2ccccc2)cc1)c1ccccc112 chemicals, 3 rings
O=C(Nc1cnon1)c1cc2ccccc2o112 chemicals, 3 rings
5H,6H,7H-Pyrrolo[1,2-c]imidazole12 chemicals, 2 rings
O=C(c1cccs1)N(Cc1ccccc1)C1CCS(=O)(=O)C112 chemicals, 3 rings![Scaffold c1cc(B2OCCO2)c2[nH]ccc2c1](/scaffold/IPGNKVKYXOCVAA-UHFFFAOYSA-N/structure.svg)
c1cc(B2OCCO2)c2[nH]ccc2c112 chemicals, 3 rings
2-Furyl 4-phenylpiperazinyl ketone12 chemicals, 3 rings
cis-Bicyclo(4.1.0)hept-3-ene12 chemicals, 2 rings
DREADD agonist 2112 chemicals, 4 rings
4-Phenyl-2-(pyridin-3-yl)thiazole12 chemicals, 3 rings
O=C(Nc1ccccc1)C1CC2CCC1O212 chemicals, 3 rings![Scaffold O=c1[nH]cnc2c[nH]nc12](/scaffold/JFZSDNLQDTYVEE-UHFFFAOYSA-N/structure.svg)
7-Ketopyrazolo(4,3-d)pyrimidine12 chemicals, 2 rings
N-(4-Phenoxyphenyl)benzamide12 chemicals, 3 rings
O=C1NCc2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C1CCCC3O112 chemicals, 8 rings
c1ccc(Nc2ncnc(-c3cc4ccccc4o3)n2)cc112 chemicals, 4 rings
Octahydro-1H-pyrrolo[3,4-c]pyridine12 chemicals, 2 rings
O=C(COC(=O)c1ccccc1)Nc1ccccn112 chemicals, 2 rings
O=c1c(-c2ccccc2)coc2cc3c(cc12)C=CCO312 chemicals, 4 rings
Pyrazolo(1,5-a)(1,3,5)triazine12 chemicals, 2 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccc[nH]2)n[nH]1](/scaffold/JZVWNUPKYQIYCF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc(-c2ccc[nH]2)n[nH]112 chemicals, 3 rings![Scaffold c1ccc2c(C3CCNCC3)c[nH]c2c1](/scaffold/KAIRZPVWWIMPFT-UHFFFAOYSA-N/structure.svg)
3-(4-Piperidinyl)-1H-indole12 chemicals, 3 rings
2-(Benzenesulfonyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide12 chemicals, 3 rings
4-(1H-Pyrazol-1-yl)pyrimidine12 chemicals, 2 rings
C1=CC(c2cccs2)C=CN112 chemicals, 2 rings
O=C1CN(N=Cc2ccc(-c3ccccc3)o2)C(=O)N112 chemicals, 3 rings
1-Benzylquinolin-4(1H)-one12 chemicals, 3 rings
5-Cyclopropyl-1,3-thiazole12 chemicals, 2 rings
3-(2-Thienyl)-1,2,4-oxadiazole12 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(CN(Cc3ccccc3)Cc3ccccc3)nc2[nH]1](/scaffold/LHCRCMLGNJCCKU-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(CN(Cc3ccccc3)Cc3ccccc3)nc2[nH]112 chemicals, 4 rings
O=C(NCCSCc1ccccc1)c1ccccc112 chemicals, 2 rings
O=C(Cn1cccn1)NN=Cc1ccccc112 chemicals, 2 rings![Scaffold O=c1[nH]c2nncn2c2ccccc12](/scaffold/LTJCKJVQPRZVDG-UHFFFAOYSA-N/structure.svg)
4H,5H-(1,2,4)Triazolo(4,3-a)quinazolin-5-one12 chemicals, 3 rings
c1ccc(OCc2ccc3ccccc3n2)cc112 chemicals, 3 rings
1,4,8,11-Tetraazacyclotetradecane12 chemicals, 1 ring
1-Benzyl-2-piperidone12 chemicals, 2 rings
(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(furan-2-yl)methanone12 chemicals, 4 rings
O=C(Nc1ccc(S(=O)(=O)Nc2ccno2)cc1)c1ccccc112 chemicals, 3 rings
2,2'-Binaphthalene12 chemicals, 4 rings
(±)-Anabasine12 chemicals, 2 rings![Scaffold O=C(Cc1ccccc1)c1c[nH]c2ccccc12](/scaffold/MVJGJYRFWKGPTI-UHFFFAOYSA-N/structure.svg)
1-(1H-Indol-3-yl)-2-phenylethanone12 chemicals, 3 rings
LD 49012 chemicals, 4 rings
O=C(NCC1CC1)OCC1c2ccccc2-c2ccccc2112 chemicals, 4 rings
3,6,9-Trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno(4,5-b)furan-2-one12 chemicals, 3 rings![Scaffold C(=Cc1cc[nH]n1)c1ccccc1](/scaffold/NFLQSIIRRGMWIY-UHFFFAOYSA-N/structure.svg)
C(=Cc1cc[nH]n1)c1ccccc112 chemicals, 2 rings
O=C1C(=O)N(CCN2CCOCC2)C(c2ccccc2)C1=Cc1ccc(OCc2ccccc2)cc112 chemicals, 5 rings
C1OCC2CC1C212 chemicals, 3 rings
Naphtho[2,1-g][1,3]benzodioxole12 chemicals, 4 rings
C(=Cc1cccc(OC2CCCCO2)c1)c1ccccc112 chemicals, 3 rings
5,8-Dihydroquinoline-5,8-dione12 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2c(nc(N3CCCCC3)n2CCSc2ncccn2)[nH]1](/scaffold/NXPPZWJHEUTJPC-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc(N3CCCCC3)n2CCSc2ncccn2)[nH]112 chemicals, 4 rings
O=C(OCc1ccccc1)C1=CN=c2sc(=Cc3ccccc3)c(=O)n2C1c1cccs112 chemicals, 5 rings
O=S(=O)(c1ccccc1)c1coc(-c2ccco2)n112 chemicals, 3 rings
4-(Benzyloxy)pyrimidine12 chemicals, 2 rings
O=C(ON=Cc1ccccc1)c1ccccc112 chemicals, 2 rings
1,3-Dihydro-2,1-benzisothiazole 2,2-dioxide12 chemicals, 2 rings
c1ccc(CB2OCCO2)cc112 chemicals, 2 rings
1-Benzyl-2-quinolone12 chemicals, 3 rings
C(=Cc1nc(-c2ccccc2)cs1)c1ccccc112 chemicals, 3 rings
O=C1CC2(C(=O)Nc3ccccc3)CCC1C212 chemicals, 3 rings