Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 421 to 480 of 15,838 scaffolds
2-Oxo-N-phenyl-2H-chromene-3-carboxamide60 chemicals, 3 rings![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
3-Benzylthio-1H-1,2,4-triazole60 chemicals, 2 rings
Benzyl phenyl sulfide60 chemicals, 2 rings
N-(2-Phenylethyl)-N'-phenylthiourea60 chemicals, 2 rings
1-Phenyl-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione60 chemicals, 4 rings![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
N-Phenyl-1H-pyrazole-3-carboxamide60 chemicals, 2 rings
N-(4,5,6,7-Tetrahydrobenzo[b]thiophen-2-yl)benzamide60 chemicals, 3 rings
1,5-Diphenyl-1H-pyrazole59 chemicals, 3 rings![Scaffold c1ccc([SiH2]c2ccccc2)cc1](/scaffold/VDCSGNNYCFPWFK-UHFFFAOYSA-N/structure.svg)
Diphenylsilane59 chemicals, 2 rings
Imidazo(1,2-b)pyridazine59 chemicals, 2 rings
Benzene, (cyclopentylmethyl)-59 chemicals, 2 rings
2-Phenyl-N-(2-phenylethyl)ethan-1-amine58 chemicals, 2 rings
N-(2-Furylmethyl)benzamide58 chemicals, 2 rings
Diphenyl disulfide58 chemicals, 2 rings
1,4-Dioxaspiro(4.5)decane58 chemicals, 2 rings
Imidazo(1,2-a)pyrazine58 chemicals, 2 rings
3-(Pyrrolidin-2-yl)pyridine58 chemicals, 2 rings
(Cyclopentyloxy)benzene58 chemicals, 2 rings
O=C1c2ccccc2C(=O)c2cc3c(cc21)CCCC3OC1CCCCO158 chemicals, 5 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1NN=Cc1ccccc1](/scaffold/UCASDEFVTQDQQM-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1NN=Cc1ccccc158 chemicals, 3 rings
c1ccc(OC2CC2)cc157 chemicals, 2 rings
Phenyl glycidyl ether57 chemicals, 2 rings![Scaffold O=c1ccnc2nc[nH]n12](/scaffold/GXBDCPYXMVITMR-UHFFFAOYSA-N/structure.svg)
1H,7H-(1,2,4)Triazolo(1,5-a)pyrimidin-7-one57 chemicals, 2 rings
O=C(Cc1ccccc1)OC1CC2CCC(C1)N257 chemicals, 3 rings
Benzyl benzoate57 chemicals, 2 rings
p-Terphenyl57 chemicals, 3 rings
Thienopyridine56 chemicals, 2 rings
O=C1CCCC2=C1C(c1ccccc1)Nc1ccccc1N256 chemicals, 4 rings
Diphenylphosphine56 chemicals, 2 rings![Scaffold O=C(CSc1nnc(-c2cnccn2)[nH]1)Nc1ccccc1](/scaffold/HZSLYHSAMJCXQO-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2cnccn2)[nH]1)Nc1ccccc156 chemicals, 3 rings![Scaffold O=c1ccc(-c2ccccc2)n[nH]1](/scaffold/IJUIPRDMWWBTTQ-UHFFFAOYSA-N/structure.svg)
3-Phenyl-6-pyridazone56 chemicals, 2 rings
3,4-Dihydro-4-phenyl-2(1H)-pyridinone56 chemicals, 2 rings
O=C1CCSC2=NC=CC(c3ccccc3)N1256 chemicals, 3 rings
4H-Pyrido[1,2-a]pyrimidin-4-one56 chemicals, 2 rings
7-(Benzyloxy)-2H-chromen-2-one56 chemicals, 3 rings
Naphthalimide56 chemicals, 3 rings
N-Pyridin-3-ylbenzamide55 chemicals, 2 rings
2-Phenoxypyrimidine55 chemicals, 2 rings
1,2-Di-1-naphthalenyldiazene55 chemicals, 4 rings
O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1ccccc155 chemicals, 4 rings
O=C(c1ccccc1)c1coc2ccccc1255 chemicals, 3 rings
C(=NN1CCN(Cc2ccccc2)CC1)c1ccccc155 chemicals, 3 rings
Octahydrocyclopenta(c)pyrrole55 chemicals, 2 rings
1,4-Dibenzylpiperazine55 chemicals, 3 rings
5-Phenylthiazole55 chemicals, 2 rings
N-Phenyl-2-((4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide54 chemicals, 4 rings![Scaffold O=c1c2ccccc2[nH]c2ccccc12](/scaffold/FZEYVTFCMJSGMP-UHFFFAOYSA-N/structure.svg)
Acridone54 chemicals, 3 rings
O=C(NN=Cc1ccc(OCc2ccccc2)cc1)c1ccccc154 chemicals, 3 rings![Scaffold O=S(Cc1ccccn1)c1nc2ccccc2[nH]1](/scaffold/HBDKFZNDMVLSHM-UHFFFAOYSA-N/structure.svg)
Timoprazole54 chemicals, 3 rings
2,3,4,5-Tetrahydro-1,4-benzoxazepine54 chemicals, 2 rings
O=C1CCCC2=C1C(c1cccs1)C=CN2c1ccccc154 chemicals, 4 rings
1,2,3,6-Tetrahydro-4-phenylpyridine54 chemicals, 2 rings
5-Benzylidene-2,4-thiazolidinedione54 chemicals, 2 rings![Scaffold O=c1[nH]c2ccccc2c(=O)o1](/scaffold/TXJUTRJFNRYTHH-UHFFFAOYSA-N/structure.svg)
Isatoic anhydride54 chemicals, 2 rings
N-Cyclopropylbenzenemethanamine54 chemicals, 2 rings
O=C1CCC2C(CCC3C4CCCC4CCC23)C153 chemicals, 4 rings
N-Phenyl-N'-2-pyridinylurea53 chemicals, 2 rings
2-(3-Oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)-N-phenylacetamide53 chemicals, 3 rings
1-Benzyl-3-pyrrolidone53 chemicals, 2 rings
c1ccc(COc2ccc3occc3c2)cc153 chemicals, 3 rings