Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 481 to 540 of 15,838 scaffolds
O=C1C(=Cc2ccccc2)Oc2ccccc2153 chemicals, 3 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1-c1ccccc1](/scaffold/QGTQPTZBBLHLBV-UHFFFAOYSA-N/structure.svg)
Diphenyl-4H-1,2,4-triazole-3-thiol53 chemicals, 3 rings
N-(Pyridin-3-ylmethyl)benzenesulfonamide53 chemicals, 2 rings
2-Phenylpiperazine53 chemicals, 2 rings
2-(3-Hydroxy-2H-1,4-benzothiazin-2-yl)-N-phenylethanimidic acid53 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2ccccc2[nH]1](/scaffold/SDQJTWBNWQABLE-UHFFFAOYSA-N/structure.svg)
Quinazolinedione53 chemicals, 2 rings![Scaffold c1cc2[nH]ccc2cn1](/scaffold/SRSKXJVMVSSSHB-UHFFFAOYSA-N/structure.svg)
5-Azaindole53 chemicals, 2 rings
1-Phenylpyrazolo(3,4-d)pyrimidine52 chemicals, 3 rings
3,4-Dihydro-2H-1,5-benzodioxepine52 chemicals, 2 rings
2-Phenyl-3,1-benzoxazin-4-one52 chemicals, 3 rings
4-Anilinopiperidine52 chemicals, 2 rings
O=C(C=Cc1ccc(-c2ccccc2)o1)Nc1ccccc152 chemicals, 3 rings
Benzamide, N-2-thienyl-52 chemicals, 2 rings
N-Phenyl-3-(1-piperidinyl)propanamide52 chemicals, 2 rings
2-Phenylpiperidine52 chemicals, 2 rings
2-(2,4-Dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-phenylacetamide52 chemicals, 3 rings
2,5-Piperazinedione51 chemicals, 1 ring
4-Phenyl-2-pyrrolidinone51 chemicals, 2 rings
2-Oxabicyclo[2.2.1]heptane51 chemicals, 2 rings
2-Phenyl-1,2,3-triazole51 chemicals, 2 rings
2-Phenyl-1,3-dioxolane51 chemicals, 2 rings
Benzophenone imine51 chemicals, 2 rings
O=c1cc(-c2ccccc2)oc2cc(OC3CCCCO3)ccc1251 chemicals, 4 rings
1,3-Diphenylpropane51 chemicals, 2 rings
1-Phenyl-1H-indole51 chemicals, 3 rings
1-(Benzenesulfonyl)-4-benzylpiperazine50 chemicals, 3 rings
O=C1C(=O)N(CCCN2CCOCC2)C(c2ccccc2)C1=Cc1ccccc150 chemicals, 4 rings
2-Benzoylbenzofuran50 chemicals, 3 rings
Benzoic acid, 2-benzoylhydrazide50 chemicals, 2 rings
1,2-Naphthoquinone50 chemicals, 2 rings
2-Benzylpyrrolidine50 chemicals, 2 rings
N-Phenyloxolane-2-carboxamide50 chemicals, 2 rings
3-Cyclopropylpyridine50 chemicals, 2 rings![Scaffold N=c1[nH]c2nc3ccccn3c(=O)c2cc1S(=O)(=O)c1ccccc1](/scaffold/PZGAFNZQCVHZMV-UHFFFAOYSA-N/structure.svg)
N=c1[nH]c2nc3ccccn3c(=O)c2cc1S(=O)(=O)c1ccccc150 chemicals, 4 rings
O=S(=O)(c1ccccc1)N1CCc2ccccc2C150 chemicals, 3 rings
2-Benzylsulfanylpyridine50 chemicals, 2 rings
Cyclooctane50 chemicals, 1 ring
C1CCC2C(C1)CCC1C2CCC2C3CCCC3CCC2150 chemicals, 5 rings![Scaffold c1cnc2c[nH]nc2c1](/scaffold/AMFYRKOUWBAGHV-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo(4,3-b)pyridine49 chemicals, 2 rings
N-(Pyridin-2-ylmethyl)benzenesulfonamide49 chemicals, 2 rings
N,4-diphenyl-1,3-thiazol-2-amine49 chemicals, 3 rings
4H,5H,6H,7H-Thieno(2,3-c)pyridine49 chemicals, 2 rings![Scaffold c1ccc(-c2ccc[nH]2)cc1](/scaffold/IRTLROCMFSDSNF-UHFFFAOYSA-N/structure.svg)
2-Phenylpyrrole49 chemicals, 2 rings
2-(Phenylamino)-4,5-dihydro-1,3-thiazol-4-one49 chemicals, 2 rings
2-Phenylethyl phenyl ether49 chemicals, 2 rings
3-Phenoxypyridine49 chemicals, 2 rings
O=C(Nc1ccccc1)c1conc1-c1ccccc149 chemicals, 3 rings
O=C(NN=Cc1c(OC(=O)c2ccccc2)ccc2ccccc12)c1ccccc149 chemicals, 4 rings
3(4H)-Quinazolineacetamide, 4-oxo-N-phenyl-49 chemicals, 3 rings![Scaffold C(=Cc1nc2ccccc2[nH]1)c1ccccc1](/scaffold/QQLPPRIZUPEKMV-UHFFFAOYSA-N/structure.svg)
C(=Cc1nc2ccccc2[nH]1)c1ccccc149 chemicals, 3 rings
5-Oxo-N,1-diphenylpyrrolidine-3-carboxamide49 chemicals, 3 rings![Scaffold O=C(CSc1nc2ccccc2[nH]1)Nc1ccccc1](/scaffold/WVWIDWYWASPVGN-UHFFFAOYSA-N/structure.svg)
Acetamide, 2-(1H-benzimidazol-2-ylthio)-N-phenyl-49 chemicals, 3 rings
2-(Pyrrolidin-1-yl)pyridine48 chemicals, 2 rings![Scaffold S=c1[nH]nc(-c2ccccn2)n1N=Cc1ccccc1](/scaffold/GALNGBXIGPDSLA-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccn2)n1N=Cc1ccccc148 chemicals, 3 rings
N-Phenylfuran-3-carboxamide48 chemicals, 2 rings
O=C1CCCC2=C1C(c1ccccc1)C=CN248 chemicals, 3 rings
Benzamide, N-cyclopropyl-48 chemicals, 2 rings
Phthalazine48 chemicals, 2 rings
4,7-Methano-1H-indene, octahydro-48 chemicals, 3 rings
1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine48 chemicals, 3 rings