Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 541 to 600 of 15,838 scaffolds
Thiomorpholine 1,1-dioxide48 chemicals, 1 ring
2,2'-Bithiophene48 chemicals, 2 rings![Scaffold c1ccc([I+]c2ccccc2)cc1](/scaffold/OZLBDYMWFAHSOQ-UHFFFAOYSA-N/structure.svg)
Diphenyliodonium48 chemicals, 2 rings
Phenazine48 chemicals, 3 rings
C1CCC(OC2CCCC(OC3CCCCO3)C2)OC148 chemicals, 3 rings
c1ccc(CC2CCC2)cc148 chemicals, 2 rings
9-Phenylcarbazole48 chemicals, 4 rings
N-Cyclohexyl-N'-phenylurea48 chemicals, 2 rings![Scaffold O=C(CSc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1ccccc1](/scaffold/ACIWZEIKODFZAM-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1ccccc147 chemicals, 4 rings
2-Benzoylthiophene47 chemicals, 2 rings
N-(Pyridin-3-ylmethyl)benzamide47 chemicals, 2 rings
Benzenemethanamine, N-cyclohexyl-47 chemicals, 2 rings
Dibenzo-P-dioxin47 chemicals, 3 rings
Triphenylamine47 chemicals, 3 rings
c1ncc2ccn(C3CCCO3)c2n147 chemicals, 3 rings
O=C(Nc1ccccc1)OCC1c2ccccc2-c2ccccc2147 chemicals, 4 rings
Thienopyrimidine47 chemicals, 2 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc(-c2cccs2)[nH]n1](/scaffold/RKHHBSJTVGBQCN-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc(-c2cccs2)[nH]n147 chemicals, 3 rings
3-Phenyloxetane47 chemicals, 2 rings
N-Phenyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide47 chemicals, 3 rings
O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O547 chemicals, 5 rings![Scaffold c1ccc(Oc2c[nH]nc2-c2ccccc2)cc1](/scaffold/VIKMERLRUOOJRO-UHFFFAOYSA-N/structure.svg)
c1ccc(Oc2c[nH]nc2-c2ccccc2)cc147 chemicals, 3 rings
3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione47 chemicals, 3 rings![Scaffold c1ccc(OCc2nc3ccccc3[nH]2)cc1](/scaffold/XATKRQREMKIRLA-UHFFFAOYSA-N/structure.svg)
2-(Phenoxymethyl)-1H-benzimidazole47 chemicals, 3 rings
N-Phenyl-2-pyrimidinamine47 chemicals, 2 rings
3,4-Dihydroisocoumarin47 chemicals, 2 rings
1,1-Diphenylethylene47 chemicals, 2 rings
O=C(Cc1ccccc1)NC1C(=O)N2CCSC1246 chemicals, 3 rings
Xanthene46 chemicals, 3 rings
Imidazo(1,2-a)pyrimidine46 chemicals, 2 rings
Pyrindan46 chemicals, 2 ringsOC1COC(n2cnc3ccccc32)C1](/scaffold/KZVDABPPBRITNB-UHFFFAOYSA-N/structure.svg)
O=C(CCC1CC2NC1=CC1=NC(=CC3=NC(=CC4=NC2CC4)CC3)CC1)NCCO[PH](=O)OC1COC(n2cnc3ccccc32)C146 chemicals, 8 rings
5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)pyridine46 chemicals, 2 rings
5-Benzylpyrimidine46 chemicals, 2 rings![Scaffold c1cc2c3c(c[nH]c3c1)CC1NCCCC21](/scaffold/RHGUXDUPXYFCTE-UHFFFAOYSA-N/structure.svg)
c1cc2c3c(c[nH]c3c1)CC1NCCCC2146 chemicals, 4 rings
O=C(CSc1nnc(COc2ccccc2)n1-c1ccccc1)Nc1ccccc146 chemicals, 4 rings
N-Benzyl-2-phenoxyacetamide46 chemicals, 2 rings
4-Phenyl-4H-1,2,4-triazole46 chemicals, 2 rings
N-(2-Phenoxyethyl)benzamide46 chemicals, 2 rings
O=C1C=CC2C1CC=CC1C3CC3CCC2145 chemicals, 4 rings
1-(Phenylmethyl)-1H-1,2,4-triazole45 chemicals, 2 rings
O=C(C=Cc1ccccc1)NCCc1ccccc145 chemicals, 2 rings
3-Phenylcyclobutanone45 chemicals, 2 rings
Pyrido[1,2-a]benzimidazole45 chemicals, 3 rings
4-Phenoxypyrimidine45 chemicals, 2 rings
O=c1c(OC2CCCCO2)c(-c2ccccc2)oc2ccccc1245 chemicals, 4 rings
1,3-Diazaspiro[4.5]decane-2,4-dione45 chemicals, 2 rings![Scaffold O=c1[nH]cnc2scc(-c3ccccc3)c12](/scaffold/OLGMRBGIXZANNV-UHFFFAOYSA-N/structure.svg)
5-Phenyl-3H,4H-thieno[2,3-d]pyrimidin-4-one45 chemicals, 3 rings
O=C(NN=Cc1ccccc1)c1ccc(OCc2ccccc2)cc145 chemicals, 3 rings
C(=Cc1ccc2ccccc2n1)c1ccccc145 chemicals, 3 rings
5-Phenylpyrazolo[1,5-a]pyrimidine45 chemicals, 3 rings![Scaffold S=c1[nH]c2ccccc2[nH]1](/scaffold/YHMYGUUIMTVXNW-UHFFFAOYSA-N/structure.svg)
2-Mercaptobenzimidazole45 chemicals, 2 rings![Scaffold c1ccc2nc3n[nH]cc3cc2c1](/scaffold/ZIZLPQUGUOCJQL-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo(3,4-b)quinoline45 chemicals, 3 rings
1-(2-Phenoxyethyl)-1H-benzimidazole45 chemicals, 3 rings
Pyrazolo[1,5-a]pyrazine44 chemicals, 2 rings
2,3,5,7A-Tetrahydro-1H-pyrrolizine44 chemicals, 2 rings
O=C(Nc1ccc2c(c1)OCCO2)c1ccccc144 chemicals, 3 rings
2-Phenylthiopyridine44 chemicals, 2 rings
B1OCc2ccccc2144 chemicals, 2 rings
2-Phenyl-2,3-dihydro-1H-perimidine44 chemicals, 4 rings