Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,441 to 1,500 of 15,838 scaffolds
![Scaffold S=c1[nH]cnc2c1ncn2C1CCCO1](/scaffold/DXIBRFHEZZOPFH-UHFFFAOYSA-N/structure.svg)
6-Mercapto-9-(tetrahydro-2-furyl)purine21 chemicals, 3 rings
O=C(NCc1ccccc1)C(=O)Nc1ccccc121 chemicals, 2 rings
N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide21 chemicals, 3 rings
c1ccc(CNc2ncnc3c2ncn3C2CCCO2)cc121 chemicals, 4 rings![Scaffold c1ccc(Cc2nn[nH]n2)cc1](/scaffold/HHDRWGJJZGJSGZ-UHFFFAOYSA-N/structure.svg)
5-Benzyl-1H-tetrazole21 chemicals, 2 rings![Scaffold c1ccc(-c2cc[nH]n2)nc1](/scaffold/HKEWOTUTAYJWQJ-UHFFFAOYSA-N/structure.svg)
2-(1H-Pyrazol-3-yl)pyridine21 chemicals, 2 rings![Scaffold c1ccc(Cc2c[nH]c3ccccc23)cc1](/scaffold/HNUYRDWMYRCVNO-UHFFFAOYSA-N/structure.svg)
3-Benzyl-1H-indole21 chemicals, 3 rings
Urea, 1-(1-naphthyl)-3-phenyl-21 chemicals, 3 rings![Scaffold c1ccc2c(c1)[nH]c1cncnc12](/scaffold/IADMQABXGAXDPF-UHFFFAOYSA-N/structure.svg)
c1ccc2c(c1)[nH]c1cncnc1221 chemicals, 3 rings
N-Phenyl-2-((6-(pyridin-2-yl)pyridazin-3-yl)thio)acetamide21 chemicals, 3 rings
O=C(Nc1cccc(C(=O)Nc2ccccc2)c1)c1ccccc121 chemicals, 3 rings
O=C(Nc1ccccc1)C1CC=CCC121 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2c(ncn2CCc2ccccc2)[nH]1](/scaffold/JFWWZQRBIJRXQC-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(ncn2CCc2ccccc2)[nH]121 chemicals, 3 rings
4-(Phenylsulfonyl)-2-piperazinone21 chemicals, 2 rings
C1=CC2c3ccccc3NC(c3ccccc3)C2C121 chemicals, 4 rings
3-{[4-(Morpholin-4-yl)phenyl]amino}-1-phenylpyrrolidine-2,5-dione21 chemicals, 4 rings
O=C(NCC1CCCCC1)c1ccccc121 chemicals, 2 rings![Scaffold O=c1[nH]nc2ccccn12](/scaffold/LJRXNXBFJXXRNQ-UHFFFAOYSA-N/structure.svg)
1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one21 chemicals, 2 rings
Dicyclopropylmethane21 chemicals, 2 rings
1-Cyclopropylimidazole21 chemicals, 2 rings
O=C(Nc1ccccc1)c1cc2ccc(-c3ccccc3)nc2s121 chemicals, 4 rings
5H,6H,8H-Imidazo[2,1-c][1,4]oxazine21 chemicals, 2 rings![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals, 2 rings
4-Benzylthiomorpholine21 chemicals, 2 rings
N-(4,5-Dihydro-thiazol-2-yl)-benzamide21 chemicals, 2 rings
c1cc2c(s1)CCCCC221 chemicals, 2 rings
N-(Phenylcarbamothioyl)furan-2-carboxamide21 chemicals, 2 rings
1,1-Dioxo-N-phenyl-1,2-benzothiazol-3-amine21 chemicals, 3 rings
Benzamide, N-2-pyrimidinyl-21 chemicals, 2 rings
Phenyl 3-pyridinecarboxylate21 chemicals, 2 rings
1-Phenylbicyclo[1.1.1]pentane21 chemicals, 4 rings
Octahydropyrrolo(3,4-c)pyrrole21 chemicals, 2 rings
1-Phenyl-3-(pyridin-3-ylmethyl)thiourea21 chemicals, 2 rings
1,2-Bis(diphenylphosphino)ethane21 chemicals, 4 rings
2-(2'-Thienyl)pyridine21 chemicals, 2 rings
3-Phenylisothiazole21 chemicals, 2 rings
N-[(2-Oxopyrrolidin-1-yl)methyl]-N-phenylbenzamide21 chemicals, 3 rings
Adipic dianilide21 chemicals, 2 rings![Scaffold O=c1[nH][nH]c2ncccc12](/scaffold/RCCFHRZLFPMPNI-UHFFFAOYSA-N/structure.svg)
1H,2H,3H-Pyrazolo[3,4-b]pyridin-3-one21 chemicals, 2 rings
Benzeneethanamine, N-phenyl-21 chemicals, 2 rings![Scaffold O=C(N=Nc1c[nH]c2ccccc12)c1ccccc1](/scaffold/RGLMVNANQLTKCX-UHFFFAOYSA-N/structure.svg)
O=C(N=Nc1c[nH]c2ccccc12)c1ccccc121 chemicals, 3 rings
1-Phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone21 chemicals, 2 rings![Scaffold O=C1Nc2ccccc2C1=Cc1ccc[nH]1](/scaffold/SEZFNTZQMWJIAI-UHFFFAOYSA-N/structure.svg)
3-(1H-Pyrrol-2-ylmethylidene)-1H-indol-2-one21 chemicals, 3 rings
1,3,2-Dioxaborolane, 2-(1-naphthalenyl)-21 chemicals, 3 rings
N-Phenyl-1,2,3,4-tetrahydro-9-acridinecarboxamide21 chemicals, 4 rings
N'-(2-(Morpholin-4-yl)ethyl)-N-phenylcarbamimidothioic acid21 chemicals, 2 rings
Phenoxazinone21 chemicals, 3 rings![Scaffold O=c1[nH]c(-c2ccccc2)cs1](/scaffold/UXIWLHNMLDJWMF-UHFFFAOYSA-N/structure.svg)
2-Hydroxy-4-phenylthiazole21 chemicals, 2 rings
N-(3-Morpholinopropyl)benzenesulfonamide21 chemicals, 2 rings
Glycoluril21 chemicals, 2 rings
3-Phenyl-1-(pyridin-3-yl)urea21 chemicals, 2 rings![Scaffold c1ccc2c(OC3CCCCO3)c[nH]c2c1](/scaffold/WQJGAAWPFNWKJM-UHFFFAOYSA-N/structure.svg)
c1ccc2c(OC3CCCCO3)c[nH]c2c121 chemicals, 3 rings
4-(Pyrimidin-4-yl)morpholine21 chemicals, 2 rings
Benzyl azetidine-1-carboxylate21 chemicals, 2 rings
Dicyclohexylamine21 chemicals, 2 rings
O=C1C(=O)N(Cc2ccco2)C(c2ccccc2)C1=Cc1ccccc121 chemicals, 4 rings
Acetamide, N-phenyl-2-(phenylsulfonyl)-21 chemicals, 2 rings
N-(1,3-Thiazol-2-yl)pyridine-3-carboxamide21 chemicals, 2 rings
2,3,4,5-Tetrahydro-1H-1,5-benzodiazepin-2-one21 chemicals, 2 rings
Pyrido(2,3-b)pyrazine21 chemicals, 2 rings