Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,381 to 1,440 of 15,838 scaffolds
2-Tetralone22 chemicals, 2 rings
5-(Thiophen-2-yl)-1,2-oxazole22 chemicals, 2 rings
2-Phenacylsulfanyl-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one22 chemicals, 5 rings
O=c1cc(CN2CCOCC2)c2ccccc2o122 chemicals, 3 rings
O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1ccco122 chemicals, 4 rings
2-(Phenoxymethyl)oxolane22 chemicals, 2 rings
3-Phenylmorpholine22 chemicals, 2 rings![Scaffold O=C(CS(=O)(=O)c1c[nH]c2ccccc12)Nc1ccccc1](/scaffold/MJQKWNKRKVKRRP-UHFFFAOYSA-N/structure.svg)
O=C(CS(=O)(=O)c1c[nH]c2ccccc12)Nc1ccccc122 chemicals, 3 rings
1-Benzenesulfonyl-4-benzo[1,3]dioxol-5-ylmethyl-piperazine22 chemicals, 4 rings
2H-1,2,4-Benzothiadiazine, 3,4-dihydro-, 1,1-dioxide22 chemicals, 2 rings![Scaffold O=c1[nH]cnc2c1nnn2-c1ccccc1](/scaffold/OVYUDMXZLUQNFP-UHFFFAOYSA-N/structure.svg)
3-Phenyl-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one22 chemicals, 3 rings
N-2-Naphthylbenzamide22 chemicals, 3 rings![Scaffold O=c1[nH]c2cccnc2[nH]1](/scaffold/PGDIPOWQYRAOSK-UHFFFAOYSA-N/structure.svg)
1,3-Dihydroimidazo(4,5-b)pyridin-2-one22 chemicals, 2 rings
RefChem:38182822 chemicals, 3 rings![Scaffold O=C(Nc1ccccc1)c1cn[nH]c1](/scaffold/QYKLBIBUERBSIN-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cn[nH]c122 chemicals, 2 rings
2,4-Piperidinedione22 chemicals, 1 ring
3H-Indole22 chemicals, 2 rings
O=c1c(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)sc2nc(-c3ccccc3)nn1222 chemicals, 6 rings
O=C1C=CC2C(=C1)CCC1C2CCC2C1CC1OCOC1222 chemicals, 5 rings
Benzyl phenylcarbamate22 chemicals, 2 rings
O=C(NN=Cc1ccc(OC(=O)c2ccccc2)cc1)C(=O)Nc1cccc2ccccc1222 chemicals, 4 rings
c1ccc(OCc2nncs2)cc122 chemicals, 2 rings
2-(2-Phenylethenyl)-1,3,2-dioxaborolane22 chemicals, 2 rings
O=C(CSc1nc2ccccc2s1)NN=Cc1ccccc122 chemicals, 3 rings![Scaffold O=c1[nH][nH]c2ccccc12](/scaffold/SWEICGMKXPNXNU-UHFFFAOYSA-N/structure.svg)
Indazolinone22 chemicals, 2 rings
2-Benzamido-N-phenylbenzamide22 chemicals, 3 rings
2,5-Diazabicyclo[2.2.1]heptane22 chemicals, 2 rings
c1ccc(-n2ccc3nc4ccccc4nc32)cc122 chemicals, 4 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1ccccc1OCc1ccccc122 chemicals, 3 rings
1-[(Phenylamino)methyl]benzotriazole22 chemicals, 3 rings![Scaffold c1coc(-c2cc[nH]n2)c1](/scaffold/XHTWJTDNZKWQON-UHFFFAOYSA-N/structure.svg)
3-(Furan-2-yl)-1H-pyrazole22 chemicals, 2 rings
Spiro[3.3]heptan-1-one22 chemicals, 2 rings
3-Oxo-3-phenylpropionanilide22 chemicals, 2 rings
2-(3-Oxopiperazin-2-yl)-N-phenylacetamide22 chemicals, 2 rings
O=C1C(=Cc2ccccc2)SC(=S)N1NS(=O)(=O)c1ccccc122 chemicals, 3 rings
2-((Phenylamino)methyl)isoindoline-1,3-dione22 chemicals, 3 rings
C1=C(B2OCCO2)CCCC122 chemicals, 2 rings
N-Phenyladamantane-1-carboxamide22 chemicals, 5 rings
N-1-Naphthylbenzamide21 chemicals, 3 rings
Piperazine, 1-phenethyl-4-phenyl-21 chemicals, 3 rings![Scaffold c1ncc2[nH]ncc2n1](/scaffold/APXRHPDHORGIEB-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo(4,3-d)pyrimidine21 chemicals, 2 rings
8-Azaspiro(4.5)decane21 chemicals, 2 rings
O=C1NC=C(C(=O)OCc2ccccc2)C(c2ccccc2)N121 chemicals, 3 rings
c1ccc(CNCC(c2ccccc2)c2ccccc2)cc121 chemicals, 3 rings
2-Phenoxyquinoxaline21 chemicals, 3 rings
1-(Azetidin-3-yl)-1H-pyrazole21 chemicals, 2 rings
4-(2-Thienyl)pyrimidine21 chemicals, 2 rings
2-Phenyl-1,2-thiazolidine 1,1-dioxide21 chemicals, 2 rings
O=C1CC(c2ccccc2)CC2=C1C(c1ccccc1)C=CN221 chemicals, 4 rings
Thiazolo[5,4-d]pyrimidine21 chemicals, 2 rings
3-Phenylcyclohexanone21 chemicals, 2 rings
O=C(COc1ccccc1)NN=Cc1c(OC(=O)c2ccccc2)ccc2ccccc1221 chemicals, 4 rings
Benzyl piperazine-1-carboxylate21 chemicals, 2 rings
Phenytoin21 chemicals, 3 rings
2-Benzyloxytetrahydropyran21 chemicals, 2 rings
N=C1C=CC(=C(c2ccccc2)c2ccccc2)C=C121 chemicals, 3 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccc2ccccc12](/scaffold/DQCVZIVQRVKNNW-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccc2ccccc1221 chemicals, 4 rings
O=C(c1cc2ccccc2o1)N(Cc1ccccc1)C1CCS(=O)(=O)C121 chemicals, 4 rings
O=C(NN=CC=Cc1ccccc1)C(=O)Nc1ccccc121 chemicals, 2 rings
2-Naphthyl benzoate21 chemicals, 3 rings