Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,501 to 1,560 of 15,838 scaffolds
5(6H)-Quinolinone, 7,8-dihydro-21 chemicals, 2 rings![Scaffold O=c1oc2ccccc2cc1-c1nc2ccccc2[nH]1](/scaffold/YRFHFTBLQARMCG-UHFFFAOYSA-N/structure.svg)
RefChem:38144521 chemicals, 4 rings
4-Phenoxy-N-phenylbutanamide21 chemicals, 2 rings
1-Azabicyclo[3.2.0]hept-2-en-7-one21 chemicals, 2 rings![Scaffold O=c1ccc2cccnc2[nH]1](/scaffold/ZFRUGZMCGCYBRC-UHFFFAOYSA-N/structure.svg)
1,8-Naphthyridin-2(1H)-one21 chemicals, 2 rings
N-Cyclopentylbenzamide21 chemicals, 2 rings
O=C1c2ccccc2NC(c2ccccc2)N1c1ccccc121 chemicals, 4 rings
C=C1C(=O)OC2C=CCCC=CCCC1220 chemicals, 2 rings
N-Cyclopropylaniline20 chemicals, 2 rings
O=C1CCCC=C1C=Nc1ccccc120 chemicals, 2 rings
O=C1CC(c2ccccc2)C2=C(CCCC2=O)N120 chemicals, 3 rings
2-Phenylimidazoline20 chemicals, 2 rings
O=C(NCNC(=S)Nc1ccccc1)c1ccco120 chemicals, 2 rings
1H-1lambda~6~,2-Benzothiazole-1,1-dione20 chemicals, 2 rings
6,9-Diphenyl-5,6,8,9,10,11-hexahydrobenzo[b][1,4]benzodiazepin-7-one20 chemicals, 5 rings![Scaffold c1ccc(N=Nc2c[nH]c3ccccc23)cc1](/scaffold/CHWPRPBKMKFUPJ-UHFFFAOYSA-N/structure.svg)
Phenylazoindole20 chemicals, 3 rings
3-Benzoylthiophene20 chemicals, 2 rings
O=C(CSc1nccn1-c1ccccc1)Nc1ccccc120 chemicals, 3 rings
O=C(CN=Nc1ccccc1)Nc1ccccc120 chemicals, 2 rings
1,2,3,4-Tetrahydroquinazolin-2-one20 chemicals, 2 rings
N-(5-Phenyl-1,3,4-thiadiazol-2-yl)benzamide20 chemicals, 3 rings
C1=C2CCC3C4CCCC4CCC3C2CCC120 chemicals, 4 rings
N-(2-Oxo-2H-pyran-3-yl)benzamide20 chemicals, 2 rings
4-(2-Phenoxyethyl)morpholine20 chemicals, 2 rings![Scaffold c1n[nH]cc1C1CC1](/scaffold/FHHRJUAWRYSTJL-UHFFFAOYSA-N/structure.svg)
4-Cyclopropyl-1H-pyrazole20 chemicals, 2 rings
O=c1c2ccsc2ncn1-c1ccccc120 chemicals, 3 rings
O=c1c2c3c(sc2ncn1-c1ccccc1)CCCC320 chemicals, 4 rings![Scaffold c1ccc(-c2ccc3nc[nH]c3c2)cc1](/scaffold/FRENWXHQIOTWRD-UHFFFAOYSA-N/structure.svg)
6-Phenyl-1H-benzimidazole20 chemicals, 3 rings
Octahydropyrrolo(1,2-a)pyrazine20 chemicals, 2 rings
O=C(Nc1ccc(CN2CCOCC2)cc1)c1ccccc120 chemicals, 3 rings
c1ccc(N=Nc2ccc3ccc(N=Nc4ccccc4)cc3c2)cc120 chemicals, 4 rings
O=C(C=Cc1ccccc1)OC1CCCCC120 chemicals, 2 rings
2-Phenoxy-N-(2-phenylethyl)acetamide20 chemicals, 2 rings![Scaffold S=c1[nH]nc(C2CCCCC2)n1N=Cc1ccccc1](/scaffold/GVAFEYZTHREACJ-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(C2CCCCC2)n1N=Cc1ccccc120 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(N3CCCC3)nc2[nH]1](/scaffold/HBEDUTKQUBPROO-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(N3CCCC3)nc2[nH]120 chemicals, 3 rings
O=c1c(-c2ccc3c(c2)OCO3)coc2ccccc1220 chemicals, 4 rings
4-Azaspiro[2.5]octane20 chemicals, 2 rings
O=C(NN=CC=Cc1ccccc1)c1ccccc120 chemicals, 2 rings![Scaffold O=c1[nH]cc(S(=O)(=O)Nc2ccccc2)c(=O)[nH]1](/scaffold/IJJVITJBNLKROU-UHFFFAOYSA-N/structure.svg)
2-Hydroxy-6-oxo-N-phenyl-1,6-dihydropyrimidine-5-sulfonamide20 chemicals, 2 rings
O=C(COc1ccccc1)Nc1cc2c(s1)CCCC220 chemicals, 3 rings
2-(Thiophen-3-yl)-1,3,2-dioxaborolane20 chemicals, 2 rings
N-Phenyl-5,6-dihydro-4H-1,3-thiazin-2-amine20 chemicals, 2 rings
1-(Cyclopropylmethyl)-1H-pyrazole20 chemicals, 2 rings
O=C(NN=Cc1ccccc1)c1cnccn120 chemicals, 2 rings
1H-Benzimidazole, 1-benzoyl-20 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2cccnc2[nH]1](/scaffold/JQPYINKVAWEQDQ-UHFFFAOYSA-N/structure.svg)
1H-Pyrido[2,3-d]pyrimidine-2,4-dione20 chemicals, 2 rings
N-[3-(1,3-Benzoxazol-2-yl)phenyl]benzamide20 chemicals, 4 rings
O=C(c1ccccc1)c1csc2c1CCCC220 chemicals, 3 rings
[(Cyclobutyloxy)methyl]benzene20 chemicals, 2 rings![Scaffold O=c1[nH][nH]c(=O)c2ccccc12](/scaffold/KGLPWQKSKUVKMJ-UHFFFAOYSA-N/structure.svg)
2,3-Dihydro-1,4-phthalazinedione20 chemicals, 2 rings
Pyrrolo(2,1-f)(1,2,4)triazine20 chemicals, 2 rings
1-Phenylphthalazine20 chemicals, 3 rings
O=c1c2ccccc2ccn1-c1ccccc120 chemicals, 3 rings
c1ccc(-c2cc3cncnc3s2)cc120 chemicals, 3 rings
Hexamide20 chemicals, 2 rings
3-Anilino-2,3-dihydro-1H-1lambda~6~-thiophene-1,1-dione20 chemicals, 2 rings
n,1-Diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine20 chemicals, 4 rings
2-Cyclopentyl-N-phenylacetamide20 chemicals, 2 rings
c1ccc(Nc2ncnc(CN3CCN(c4ccccc4)CC3)n2)cc120 chemicals, 4 rings
O=C(c1ccccc1)N1CCOc2ccccc2120 chemicals, 3 rings