Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,561 to 1,620 of 15,838 scaffolds
4-Phenyl-1,3-oxazole20 chemicals, 2 rings![Scaffold O=C(CSc1nnc(Cn2c(=O)sc3ccccc32)[nH]1)Nc1ccccc1](/scaffold/OMLJDCPDZMFWIQ-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(Cn2c(=O)sc3ccccc32)[nH]1)Nc1ccccc120 chemicals, 4 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1c(OC(=O)c2ccccc2)ccc2ccccc1220 chemicals, 4 rings
9-Phenyl-2,3,4,5,6,7,9,10-octahydroacridine-1,8-dione20 chemicals, 4 rings
N-(2-(Benzoylamino)phenyl)benzamide20 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(nc(NCc3ccccc3)n2Cc2ccccc2)[nH]1](/scaffold/PFBIFWAJSJQHQA-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc(NCc3ccccc3)n2Cc2ccccc2)[nH]120 chemicals, 4 rings
O=C(CNC(=O)OCc1ccccc1)NCCc1ccccc120 chemicals, 2 rings
(E)-5-Benzyl-2-(phenylimino)thiazolidin-4-one20 chemicals, 3 rings
O=c1cc(-c2cc3ccccc3o2)c2ccccc2o120 chemicals, 4 rings![Scaffold c1ccc(CNCCc2c[nH]c3ccccc23)cc1](/scaffold/PRRZWJAGZHENJJ-UHFFFAOYSA-N/structure.svg)
N-Benzyltryptamine20 chemicals, 3 rings
O=C(CSc1nnc(CNc2ccccc2)n1-c1ccccc1)Nc1ccccc120 chemicals, 4 rings![Scaffold c1ccc(-c2nnc[nH]2)nc1](/scaffold/PVMLJDLTWMGZAH-UHFFFAOYSA-N/structure.svg)
2-(1H-1,2,4-Triazol-3-yl)pyridine20 chemicals, 2 rings
N-Benzyl-1-benzofuran-2-carboxamide20 chemicals, 3 rings
2-Cyclopropyl-1,3-thiazole20 chemicals, 2 rings![Scaffold O=c1[nH]c(SCc2ccccc2)nc2sccc12](/scaffold/QRXXBGREQCHFDW-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(SCc2ccccc2)nc2sccc1220 chemicals, 3 rings
4H,5H,6H,7H-(1,3)Thiazolo(5,4-c)pyridine20 chemicals, 2 rings
O=C(Nc1ccc(N2CCCC2)cc1)c1ccccc120 chemicals, 3 rings
O=C(NC1CCCc2ccccc21)c1ccccc120 chemicals, 3 rings
O=C(COc1ccccc1)N1CCN(c2ccccc2)CC120 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(CN3CCOCC3)nc2[nH]1](/scaffold/QZWXCOLLEUINDB-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(CN3CCOCC3)nc2[nH]120 chemicals, 3 rings
Furo[2,3-b]pyridine20 chemicals, 2 rings
Ethanone, 1-phenyl-2-(1-pyrrolidinyl)-20 chemicals, 2 rings
O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)c1ccccc120 chemicals, 4 rings
N-(3-Imidazol-1-ylpropyl)benzenesulfonamide20 chemicals, 2 rings
2,3,4,5-Tetrahydro-1H-2-benzazepine20 chemicals, 2 rings
N-Phenyl-3-pyrrolidin-1-ylpropanamide20 chemicals, 2 rings
5-Methylene-10,11-dihydro-5H-dibenzo[a,d][7]annulene20 chemicals, 3 rings
c1ccc(NCCCn2c3ccccc3c3ccccc32)cc120 chemicals, 4 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=CC=Cc1ccccc1](/scaffold/UDTHRFOLUQLNEZ-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=CC=Cc1ccccc120 chemicals, 3 rings
5-Azaspiro[2.5]octane20 chemicals, 2 rings
O=C1NC(=S)SC1=Cc1c(N2CCCCC2)nc2ccccn2c1=O20 chemicals, 4 rings
2-Benzyl-1-phthalazinone20 chemicals, 3 rings
O=C1CCC2C(CCC3C4CCC5CCCCC5C4=CCC23)C120 chemicals, 5 rings
N-Cyclopentylaniline20 chemicals, 2 rings
Furo[3,2-c]pyridine20 chemicals, 2 rings
Benzene, 1,1'-cyclohexylidenebis-20 chemicals, 3 rings
5,6,7,8-Tetrahydroimidazo(1,5-a)pyrazine20 chemicals, 2 rings
O=C(Nc1cc(-c2ccccc2)cs1)c1ccccc120 chemicals, 3 rings![Scaffold c1ccc(-c2[o+]c3ccccc3cc2OC2CCCCO2)cc1](/scaffold/WYFXJWBLGGSNTA-UHFFFAOYSA-N/structure.svg)
c1ccc(-c2[o+]c3ccccc3cc2OC2CCCCO2)cc120 chemicals, 4 rings
1-Hydroxy-3-[(phenylsulfonyl)amino]thiolan-1-one20 chemicals, 2 rings
Ethanone, 2-(benzoyloxy)-1-phenyl-20 chemicals, 2 rings
Phenylthiohydantoin20 chemicals, 2 rings
5-Oxa-8-azaspiro(3.5)nonane19 chemicals, 2 rings
O=C1NC(=O)c2cc(Oc3ccccc3)ccc2119 chemicals, 3 rings
Octahydropentalene19 chemicals, 2 rings
Benzylstyrene19 chemicals, 2 rings
3-Phenyl-1-(pyrrolidin-1-yl)propan-1-one19 chemicals, 2 rings
2H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one19 chemicals, 2 rings
1-Benzyl-1H-1,2,3,4-tetrazole19 chemicals, 2 rings
4H-1,2,4-Benzothiadiazine, 1,1-dioxide19 chemicals, 2 rings![Scaffold O=c1ccc(=O)[nH][nH]1](/scaffold/BGRDGMRNKXEXQD-UHFFFAOYSA-N/structure.svg)
Maleic hydrazide19 chemicals, 1 ring
3-Piperidinopropiophenone19 chemicals, 2 rings
2-(2-Oxobenzo[d]oxazol-3(2H)-yl)-N-phenylacetamide19 chemicals, 3 rings
N-Phenyl-[1,1'-biphenyl]-4-carboxamide19 chemicals, 3 rings
4-(1H-Pyrazol-1-yl)pyridine19 chemicals, 2 rings
O=C(NN=Cc1ccccc1)C(=O)Nc1cccc2ccccc1219 chemicals, 3 rings![Scaffold N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCc1ccco1](/scaffold/CBDLDEBXCDURMB-UHFFFAOYSA-N/structure.svg)
N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCc1ccco119 chemicals, 4 rings
Phenylfurazan19 chemicals, 2 rings
O=C1C(=Cc2ccccc2)CCCC1=Cc1ccccc119 chemicals, 3 rings
8-Azabicyclo(3.2.1)octan-3-one19 chemicals, 2 rings