Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,981 to 2,040 of 15,838 scaffolds
![Scaffold N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCC1CCCO1](/scaffold/HSAQEPNIKWVOKX-UHFFFAOYSA-N/structure.svg)
N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCC1CCCO116 chemicals, 4 rings
Tetrahydropyranyl ether16 chemicals, 2 rings
N-(Benzylideneamino)-2-naphthalen-2-yloxy-acetamide16 chemicals, 3 rings
C1=C2C3CCCCC3CCC2C2CCC3CC(OC4OCC(OC5CCCCO5)CC4OC4CCCCO4)CCC3C2C116 chemicals, 8 rings
1H-Imidazole, 1-(2-phenoxyethyl)-16 chemicals, 2 rings
c1ccc(C2=NCc3cncn3-c3ccccc32)cc116 chemicals, 4 rings
N-(Pyridin-4-ylmethyl)aniline16 chemicals, 2 rings![Scaffold c1ccc2c(c1)ncc1nc[nH]c12](/scaffold/ITIRVXDSMXFTPW-UHFFFAOYSA-N/structure.svg)
Imidazo(4,5-c)quinoline16 chemicals, 3 rings
3-(2-Oxo-1,3-benzoxazol-3-yl)-N-phenylpropanamide16 chemicals, 3 rings
c1ccc(COC(Cn2ccnc2)c2ccccc2)cc116 chemicals, 3 rings
O=C(Nc1ccn2c(n1)nc1ccccc12)c1ccccc116 chemicals, 4 rings
2-(2-Imino-4-oxo-1,3-thiazolidin-5-yl)-N-phenylacetamide16 chemicals, 2 rings![Scaffold O=c1[nH]c(Nc2ccccc2)nc2[nH]cnc12](/scaffold/JDCULXHGRMPCAM-UHFFFAOYSA-N/structure.svg)
N(2)-Phenylguanine16 chemicals, 3 rings
N1,N4-Dibenzylidenebenzene-1,4-diamine16 chemicals, 3 rings
2-(Benzylthio)benzo[d]thiazole16 chemicals, 3 rings
Benzamide, N-[2-(phenylamino)ethyl]-16 chemicals, 2 rings(c2ccccc2)c2ccccc2)cc1](/scaffold/JLAVCPKULITDHO-UHFFFAOYSA-N/structure.svg)
1,1',1'',1'''-Silanetetrayltetrakis(benzene)16 chemicals, 4 rings
1-(1,3-Benzodioxol-5-ylmethyl)-3-phenylthiourea16 chemicals, 3 rings
3-CyclobutylPyridine16 chemicals, 2 rings
c1ccc(-n2ccc3cncnc32)cc116 chemicals, 3 rings
4-Benzylthiomorpholine 1,1-dioxide16 chemicals, 2 rings
O=C(Nc1ccccc1)C1CCCN1S(=O)(=O)c1ccccc116 chemicals, 3 rings
4-Phenyl-2-(1H-pyrazol-1-yl)-1,3-thiazole16 chemicals, 3 rings![Scaffold O=c1[nH]c(-c2ccccc2)no1](/scaffold/LMBDRBXGTCUBIH-UHFFFAOYSA-N/structure.svg)
3-Phenyl-4,5-dihydro-1,2,4-oxadiazol-5-one16 chemicals, 2 rings
4-Cyclobutylpiperidine16 chemicals, 2 rings![Scaffold O=[PH]1OCC2OC(n3cnc4cncnc43)CC2O1](/scaffold/LQOCNOQFAOTVSI-UHFFFAOYSA-N/structure.svg)
O=[PH]1OCC2OC(n3cnc4cncnc43)CC2O116 chemicals, 4 rings
2-Cyclopropyl-1,3-oxazole16 chemicals, 2 rings
O=C(C=Cc1ccco1)Nc1ccccc116 chemicals, 2 rings
1-Phenylimidazolidine-2,4-dione16 chemicals, 2 rings![Scaffold O=C(Nc1ccccc1)c1ccc[nH]1](/scaffold/MZPAQCAPWLAKSD-UHFFFAOYSA-N/structure.svg)
N-Phenyl-1H-pyrrole-2-carboxamide16 chemicals, 2 rings
N-Benzhydrylbenzamide16 chemicals, 3 rings![Scaffold [N+]=c1ccc2nc3ccccc3sc-2c1](/scaffold/NBGVUPDILUEXEV-UHFFFAOYSA-N/structure.svg)
[N+]=c1ccc2nc3ccccc3sc-2c116 chemicals, 3 rings
6,7-Dihydro-5H-pyrrolo(3,4-d)pyrimidine16 chemicals, 2 rings![Scaffold c1cc(-c2cn[nH]c2)n[nH]1](/scaffold/NITMEARQZCUGRR-UHFFFAOYSA-N/structure.svg)
c1cc(-c2cn[nH]c2)n[nH]116 chemicals, 2 rings
N-(2-(Furan-2-yl)-2-(indolin-1-yl)ethyl)benzamide16 chemicals, 4 rings
N,N'-Diphenylethylenediamine16 chemicals, 2 rings![Scaffold O=c1c(N=Nc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/NRYKBUOQTITJGB-UHFFFAOYSA-N/structure.svg)
1H-Pyrazole-4,5-dione, 1-phenyl-, 4-(phenylhydrazone)16 chemicals, 3 rings
N,N'-1,2-Ethanediylbisbenzamide16 chemicals, 2 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1Cc1ccccc1](/scaffold/NXUULZDTTMJDAI-UHFFFAOYSA-N/structure.svg)
4-Benzyl-5-phenyl-4H-1,2,4-triazole-3-thiol16 chemicals, 3 rings
O=C1OC(C(=O)Nc2ccccc2)Cc2ccccc2116 chemicals, 3 rings
7,8-Dihydro-5H-pyrano[4,3-b]pyridine16 chemicals, 2 rings
C1COC2(C1)CCC216 chemicals, 2 rings
Benzene, bis(phenylmethyl)-16 chemicals, 3 rings
c1ccc(OCCn2ccc3ccccc32)cc116 chemicals, 3 rings
Phenyl-5-thiazolylmethanone16 chemicals, 2 rings![Scaffold c1cc(-c2ncn[nH]2)ccn1](/scaffold/OYJDWYWNACFAQB-UHFFFAOYSA-N/structure.svg)
1H-1,2,4-Triazole, 5-(4-pyridyl)-16 chemicals, 2 rings
O=C1C(=O)N(CCN2CCOCC2)C(c2ccccc2)C1=Cc1ccccc116 chemicals, 4 rings
1,2,3,4-Tetrahydro-2,7-naphthyridine16 chemicals, 2 rings
Ethanone, 2-(1H-benzimidazol-1-yl)-1-phenyl-16 chemicals, 3 rings
N-(Furan-2-ylmethylene)aniline16 chemicals, 2 rings
N-Phenyl-2-[(6-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]acetamide16 chemicals, 4 rings
O=C(Cn1ccc2ccccc21)Nc1ccccc116 chemicals, 3 rings
N-Phenyl-2-[(6-pyridin-2-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]acetamide16 chemicals, 4 rings
2-((1-Benzyl-1H-imidazol-2-yl)thio)-N-phenylacetamide16 chemicals, 3 rings
1,2-Ethanediamine, N1,N2-bis(phenylmethylene)-16 chemicals, 2 rings
2-Benzyl-1,3,4-oxadiazole16 chemicals, 2 rings![Scaffold N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCc1cccnc1](/scaffold/QITFJFPPQKEMSP-UHFFFAOYSA-N/structure.svg)
N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCc1cccnc116 chemicals, 4 rings
O=C(CCn1c2c(c3ccccc31)CCCC2)NN=Cc1ccccc116 chemicals, 4 rings
2-(Phenylazo)pyridine16 chemicals, 2 rings
2,3-Dihydro-1,4-dioxino[2,3-b]pyridine16 chemicals, 2 rings