Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,861 to 1,920 of 15,838 scaffolds
1-Phenethyl-3-phenylurea17 chemicals, 2 rings![Scaffold C1=CC2CCC3Nc4ccc(C5CC6CCCN(CCc7c5[nH]c5ccccc75)C6)cc4C34CCN(C1)C24](/scaffold/IDKFHPRIUNPTCC-UHFFFAOYSA-N/structure.svg)
C1=CC2CCC3Nc4ccc(C5CC6CCCN(CCc7c5[nH]c5ccccc75)C6)cc4C34CCN(C1)C2417 chemicals, 9 rings
1-(2-Tetrahydropyranyl)-1H-pyrazole17 chemicals, 2 rings
1-Phenyl-4,5-dihydro-1H-pyrazole17 chemicals, 2 rings
1-(3-Phenoxypropyl)piperazine17 chemicals, 2 rings
O=C(CN1CCc2ccccc2C1)Nc1ccccc117 chemicals, 3 rings
c1ccc(C(c2cn3ncnc3s2)N2CCCCC2)cc117 chemicals, 4 rings
c1cc(C2CC2)ccc1B1OCCO117 chemicals, 3 rings
C(=NC1CCCCC1N=Cc1ccccc1)c1ccccc117 chemicals, 3 rings
c1ccc(N=c2ccc3ccccc3o2)cc117 chemicals, 3 rings
3-Phenyl-2,6-piperidinedione17 chemicals, 2 rings![Scaffold O=C1CCCc2[nH]ccc21](/scaffold/KASJZXHXXNEULX-UHFFFAOYSA-N/structure.svg)
1,5,6,7-Tetrahydro-4H-indol-4-one17 chemicals, 2 rings![Scaffold c1n[nH]c2c1CCNC2](/scaffold/KFOAQYYCEAGMEF-UHFFFAOYSA-N/structure.svg)
1H,4H,5H,6H,7H-Pyrazolo(3,4-c)pyridine17 chemicals, 2 rings
O=c1ccoc2c1OC=CC2c1ccccc117 chemicals, 3 rings![Scaffold O=C(C[n+]1ccccc1)c1ccccc1](/scaffold/KUUXBQKORDCEFO-UHFFFAOYSA-N/structure.svg)
1-(2-Oxo-2-phenylethyl)pyridinium bromide17 chemicals, 2 rings
2-(1,3,2-Dioxaborolan-2-yl)pyridine17 chemicals, 2 rings![Scaffold S=c1ccc2ccccc2[nH]1](/scaffold/KXZSVYHFYHTNBI-UHFFFAOYSA-N/structure.svg)
2(1H)-Quinolinethione17 chemicals, 2 rings![Scaffold O=c1ccnc2cc(-c3ccccc3)[nH]n12](/scaffold/LCIWNFJRZJKIJM-UHFFFAOYSA-N/structure.svg)
2-Phenylpyrazolo[1,5-a]pyrimidin-7-ol17 chemicals, 3 rings
1,7-Diphenylheptan-3-one17 chemicals, 2 rings
1-Phenethylpiperazine17 chemicals, 2 rings
O=C(Nc1ccccc1)c1cc(-c2ccccc2)nc2ccccc1217 chemicals, 4 rings
(E)-2-(Phenyldiazenyl)thiazole17 chemicals, 2 rings
5,6-Dihydro-4H-pyrrolo(1,2-b)pyrazole17 chemicals, 2 rings
O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)nc2ccccc1217 chemicals, 4 rings
2-Cyclopropylthiophene17 chemicals, 2 rings
Naphtho(2,1-b)furan17 chemicals, 3 rings
O=C(C=Cc1ccccc1)OCCc1ccccc117 chemicals, 2 rings
4-(Phenoxymethyl)thiazole17 chemicals, 2 rings
Phenacyl phenyl sulfide17 chemicals, 2 rings
2-(2-Phenylethyl)pyridine17 chemicals, 2 rings
c1ccc(N2CCN(Cc3ccco3)CC2)cc117 chemicals, 3 rings
7-Phenyl-[1,2,4]triazolo[1,5-a]pyrimidine17 chemicals, 3 rings
N-Phenylpyrrolidine-1-carboxamide17 chemicals, 2 rings![Scaffold O=c1[nH]cc(C=Nc2ccccc2)c(=O)[nH]1](/scaffold/NUKNFFVSYCMXHY-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cc(C=Nc2ccccc2)c(=O)[nH]117 chemicals, 2 rings
3-Cyclobutyl-1,2-oxazole17 chemicals, 2 rings
N-(Morpholin-4-yl)benzamide17 chemicals, 2 rings
9H-Fluoren-9-ylmethyl N-cyclohexylcarbamate17 chemicals, 4 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1cccs117 chemicals, 2 rings
N-Phenyl-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio)acetamide17 chemicals, 3 rings
O=C1CCCC2=C1C(c1ccccc1)C(C(=O)Nc1ccccc1)=CN217 chemicals, 4 rings
2-(2-Thienyl)thiazole17 chemicals, 2 rings
Imidazo(2,1-b)thiazole, 5,6-dihydro-3-phenyl-17 chemicals, 3 rings
2-(Pyrrolidin-1-yl)pyrimidine17 chemicals, 2 rings
4-Phenyl-2-thiophen-2-yl-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalene17 chemicals, 5 rings
Benzyl(benzylsulfamoyl)amine17 chemicals, 2 rings
2-Benzyl-3,4-dihydro-1H-isoquinoline17 chemicals, 3 rings![Scaffold O=c1[nH]cnc2ccsc12](/scaffold/PZMKGWRBZNOIPQ-UHFFFAOYSA-N/structure.svg)
3H,4H-Thieno[3,2-d]pyrimidin-4-one17 chemicals, 2 rings
c1ccc(Sc2ccnc(-c3ccccc3)n2)cc117 chemicals, 3 rings
6-Oxa-3-azabicyclo[3.2.1]octane17 chemicals, 2 rings
O=C(COc1ccc(-c2ccccc2)cc1)NN=Cc1ccccc117 chemicals, 3 rings![Scaffold c1cc2[nH]ncc2cc1B1OCCO1](/scaffold/QOTFKHYPOZUMGU-UHFFFAOYSA-N/structure.svg)
c1cc2[nH]ncc2cc1B1OCCO117 chemicals, 3 rings
5,6,7,8-Tetrahydroindolizine17 chemicals, 2 rings
O=C(COC(=O)c1ccccc1)NC1CCCC117 chemicals, 2 rings
5-Azaspiro[2.3]hexane17 chemicals, 2 rings
5-(Phenoxymethyl)-3-phenyl-1,2,4-oxadiazole17 chemicals, 3 rings
Phenyl-3-pyridinylmethanone17 chemicals, 2 rings
1-(2-Furoyl)piperazine17 chemicals, 2 rings![Scaffold O=c1ccc2c([nH]1)CCCC2](/scaffold/SGKURJURKCHGJG-UHFFFAOYSA-N/structure.svg)
1,2,5,6,7,8-Hexahydroquinolin-2-one17 chemicals, 2 rings
O=c1sc2ccccc2n1Cc1nncn1-c1ccccc117 chemicals, 4 rings
O=C(COc1cccc2ccccc12)NN=Cc1ccccc117 chemicals, 3 rings