Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,101 to 2,160 of 15,838 scaffolds
3-(Benzyloxy)thiophene15 chemicals, 2 rings
3-Cyclopropylpiperidine15 chemicals, 2 rings
C(=NNc1ccccc1)C1=Nc2ccccc2C115 chemicals, 3 rings
2,7-Diazaspiro[3.5]nonane15 chemicals, 2 rings
Benzamide, N-[2-(phenylthio)ethyl]-15 chemicals, 2 rings
c1cc2cc(c1)Oc1ccc(cc1)CC1NCCc3ccc(cc31)Oc1cccc3c1C(C2)NCC315 chemicals, 8 rings
O=C1C=CC2OC3CCC(C2C1)C31CO115 chemicals, 4 rings![Scaffold O=C(Nc1ccc(-c2nc3ccccc3[nH]2)cc1)c1ccccc1](/scaffold/FBQLHSPREUMECT-UHFFFAOYSA-N/structure.svg)
Benzamide, N-[4-(1H-benzimidazol-2-yl)phenyl]-15 chemicals, 4 rings
O=C(CC(NC(=O)c1ccccc1)c1ccccc1)OC1C=C2CC(=O)C3CCC4OCC4C3C(OC(=O)c3ccccc3)C(C2)C115 chemicals, 7 rings
N-(2-Phenyl-1,3-benzoxazol-5-yl)benzamide15 chemicals, 4 rings
N-(Quinolin-8-yl)benzenesulfonamide15 chemicals, 3 rings
O=C(NN=Cc1cn(-c2ccccc2)nc1-c1ccccc1)C(=O)Nc1ccccc115 chemicals, 4 rings
1-Phenyl-3-pyrimidin-2-ylurea15 chemicals, 2 rings
Thiazolo[4,5-c]pyridine15 chemicals, 2 rings
4-Benzyl-1-phenethyl-piperidine15 chemicals, 3 rings![Scaffold c1cc2cn[nH]c2s1](/scaffold/FKWUPVHNVKGGSD-UHFFFAOYSA-N/structure.svg)
c1cc2cn[nH]c2s115 chemicals, 2 rings![Scaffold O=C1NCCc2c1[nH]c1ccccc21](/scaffold/FZHZQHNKCPJTNQ-UHFFFAOYSA-N/structure.svg)
2,3,4,9-Tetrahydro-1H-pyrido(3,4-b)indol-1-one15 chemicals, 3 rings
RefChem:38215215 chemicals, 4 rings
1-Phenyl-2-((4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)ethanone15 chemicals, 4 rings
1,2,4-Benzotriazene15 chemicals, 2 rings
O=C(CSc1nc(=O)n2ccccc2n1)Nc1ccccc115 chemicals, 3 rings
4H,5H,6H,7H-Pyrazolo(1,5-a)pyrazin-4-one15 chemicals, 2 rings![Scaffold S=c1nc[nH]c2nc[nH]c12](/scaffold/GLVAUDGFNGKCSF-UHFFFAOYSA-N/structure.svg)
6-Mercaptopurine15 chemicals, 2 rings
Azepan-4-one15 chemicals, 1 ring
O=c1c2ccccc2ncn1N=Cc1ccccc115 chemicals, 3 rings![Scaffold O=C(NN=Cc1c[nH]c2ccccc12)c1ccccc1](/scaffold/GPZLLYBQEWHEKL-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1c[nH]c2ccccc12)c1ccccc115 chemicals, 3 rings
N1-phenyl-N2-(pyridin-2-ylmethyl)oxalamide15 chemicals, 2 rings![Scaffold O=c1[nH]c2ccc(S(=O)(=O)Nc3ccccc3)cc2[nH]1](/scaffold/HARJCSAMFNUPPH-UHFFFAOYSA-N/structure.svg)
2-Oxo-N-phenyl-2,3-dihydro-1H-benzimidazole-5-sulfonamide15 chemicals, 3 rings
O=C(Cn1cccn1)NCc1ccccc115 chemicals, 2 rings
O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc2115 chemicals, 4 rings
O=C(c1ccccc1)c1ccc2ccc3ccc4cccnc4c3n1215 chemicals, 5 rings![Scaffold O=C1CC2SCC(CSc3nnn[nH]3)=CN12](/scaffold/HIXLVAANHSDQNW-UHFFFAOYSA-N/structure.svg)
O=C1CC2SCC(CSc3nnn[nH]3)=CN1215 chemicals, 3 rings
O=C(C=Cc1ccccc1)Nc1nccs115 chemicals, 2 rings
O=C(COc1ccc(-c2ccccc2)cc1)NN=Cc1ccc(OC(=O)c2ccccc2)cc115 chemicals, 4 rings
c1ccc(OCCCCn2cnc3ccccc32)cc115 chemicals, 3 rings
O=C1C(=O)N(CCCn2ccnc2)C(c2ccccc2)C1=Cc1ccccc115 chemicals, 4 rings
2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrimidine15 chemicals, 3 rings
Dabco15 chemicals, 3 rings
O=C1CC(c2ccccc2)Oc2cc(OC3CCCCO3)ccc2115 chemicals, 4 rings![Scaffold O=c1[nH]c(SCc2ccccc2)nc2sc3c(c12)CCCC3](/scaffold/IPZMSKIJUYVNKQ-UHFFFAOYSA-N/structure.svg)
2-(Benzylsulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one15 chemicals, 4 rings
4-Azaspiro[2.4]heptane15 chemicals, 2 rings
1-(2-Phenylethyl)-1H-pyrazole15 chemicals, 2 rings
N-(5-Benzyl-1,3,4-thiadiazol-2-yl)benzamide15 chemicals, 3 rings
1,4-Diphenyl-1,3-butadiene15 chemicals, 2 rings
O=C(Nc1ccccc1N1CCNCC1)c1ccccc115 chemicals, 3 rings
Norquetiapine15 chemicals, 4 rings
c1ccc(CSc2nnc(-c3ccccc3)o2)cc115 chemicals, 3 rings
1,3-Diazaspiro(4.4)nonane-2,4-dione15 chemicals, 2 rings
2-Phenyl-1,2-benzisothiazol-3-(2H)-one15 chemicals, 3 rings
1-(Phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine15 chemicals, 3 rings
N,5-Diphenyl-1,2-oxazole-3-carboxamide15 chemicals, 3 rings
O=C(NN=Cc1cccc(OC(=O)c2ccccc2)c1)C(=O)Nc1ccccc115 chemicals, 3 rings
3,6-Diphenyl-1,2,4-triazolo(3,4-b)(1,3,4)thiadiazole15 chemicals, 4 rings
O=C(OC1C2CCC3C4CC5C6CCCC5(C(C2)C31)C4NC6)c1ccccc115 chemicals, 7 rings
1-(2-Phenylethyl)-1H-pyrrole15 chemicals, 2 rings
O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o115 chemicals, 4 rings![Scaffold c1ccc(-c2n[nH]c(-c3ccccc3)n2)cc1](/scaffold/KPKQWXGFEKRQQA-UHFFFAOYSA-N/structure.svg)
3,5-Diphenyl-1H-1,2,4-triazole15 chemicals, 3 rings
2,3-Dihydro-1H-imidazo(1,2-b)pyrazole15 chemicals, 2 rings![Scaffold c1ccc(Cc2ccn[nH]2)cc1](/scaffold/KTFGWHSLIOZEKH-UHFFFAOYSA-N/structure.svg)
5-Benzyl-1H-pyrazole15 chemicals, 2 rings
4-(1,2,5-Thiadiazol-3-yl)morpholine15 chemicals, 2 rings