Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 661 to 720 of 15,838 scaffolds
1-(2-Pyrimidinyl)piperazine41 chemicals, 2 rings![Scaffold O=c1[nH]cnc2sc3c(c12)CCCC3](/scaffold/NMMOEJUJKIXUQZ-UHFFFAOYSA-N/structure.svg)
5,6,7,8-Tetrahydro(1)benzothieno(2,3-D)pyrimidin-4(3H)-one41 chemicals, 3 rings
Pyridine, 3-(phenylsulfonyl)-41 chemicals, 2 rings
O=C(CSc1ccccn1)Nc1ccccc141 chemicals, 2 rings
N-Phenyl-2-(2-thienyl)acetamide41 chemicals, 2 rings
N-Phenyl-3-(piperazin-1-yl)propanamide41 chemicals, 2 rings
N-Phenylpiperidine-1-carbothioamide41 chemicals, 2 rings
Benzil41 chemicals, 2 rings
3-Phenylpyridazine41 chemicals, 2 rings
O=S(=O)(NCc1ccc2c(c1)OCO2)c1ccccc141 chemicals, 3 rings
O=C1NC=C(C(=O)Nc2ccccc2)C(c2ccccc2)N141 chemicals, 3 rings![Scaffold [N+]=C1C=CC(=C(c2ccccc2)c2ccccc2)C=C1](/scaffold/ZMDDANKTRSYYRH-UHFFFAOYSA-N/structure.svg)
[N+]=C1C=CC(=C(c2ccccc2)c2ccccc2)C=C141 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(ncn2CCCc2ccccc2)[nH]1](/scaffold/ZRAIUQWSDYKKRJ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(ncn2CCCc2ccccc2)[nH]141 chemicals, 3 rings![Scaffold O=c1[nH]c2ccccc2[nH]c1=O](/scaffold/ABJFBJGGLJVMAQ-UHFFFAOYSA-N/structure.svg)
2,3-Dihydroxyquinoxaline40 chemicals, 2 rings
O=C(Cc1ccccc1)OC1CC2NC(C1)C1OC2140 chemicals, 4 rings
N-Benzylquinazolin-4-amine40 chemicals, 3 rings
1,2,3,4-Tetrahydroquinoxaline40 chemicals, 2 rings
5,6-Dihydro-4H-cyclopenta[b]thiophene40 chemicals, 2 rings
1,2,3,4,4a,9,10,10a-Octahydrophenanthrene40 chemicals, 3 rings
1H-Pyrazole, 1-phenyl-4-(phenylazo)-40 chemicals, 3 rings
4,5,6,7-Tetrahydrothieno(3,2-c)pyridine40 chemicals, 2 rings![Scaffold O=c1[nH]c(=S)[nH]c2ccccc12](/scaffold/PUPFOFVEHDNUJU-UHFFFAOYSA-N/structure.svg)
2-Mercapto-4(3H)-quinazolinone40 chemicals, 2 rings![Scaffold c1ccc2c3c([nH]c2c1)CCNC3](/scaffold/RPROHCOBMVQVIV-UHFFFAOYSA-N/structure.svg)
1H,2H,3H,4H,5H-Pyrido[4,3-b]indole40 chemicals, 3 rings
6H-Dibenzo(b,d)pyran-6-one40 chemicals, 3 rings
1-Benzyl-4-phenylpiperazine40 chemicals, 3 rings
C1CCC(COC2CCCCO2)OC140 chemicals, 2 rings![Scaffold O=c1ccnc(SCc2ccccc2)[nH]1](/scaffold/XLYQVVDCFZRIJB-UHFFFAOYSA-N/structure.svg)
2-(Benzylsulfanyl)pyrimidin-4-ol40 chemicals, 2 rings
C1CC2(C1)CCN240 chemicals, 2 rings
O=C1CCC2C1CCC1c3ccccc3CCC1239 chemicals, 4 rings
O=C(OC1CC2CCC(C1)N2)c1ccccc139 chemicals, 3 rings
c1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc139 chemicals, 4 rings![Scaffold c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc1](/scaffold/DBVANQGRXKUFCH-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc139 chemicals, 3 rings
O=c1ccc2ccc3c(c2o1)CCCO339 chemicals, 3 rings
N-Phenylthiophene-2-sulfonamide39 chemicals, 2 rings
5-CyclopropylIsoxazole39 chemicals, 2 rings
O=C1C(=O)N(c2nncs2)C(c2ccccc2)C1=Cc1ccccc139 chemicals, 4 rings
O=C(CN1CCN(Cc2ccccc2)CC1)NN=Cc1ccccc139 chemicals, 3 rings
2-Azabicyclo(2.2.2)octane39 chemicals, 3 rings
2-Phenoxy-1-phenylethanone39 chemicals, 2 rings
2,4-Diphenylthiazole39 chemicals, 3 rings
Phenindione39 chemicals, 3 rings
c1ccc(-c2cncnc2-c2ccccc2)cc139 chemicals, 3 rings![Scaffold [N+]=c1ccc2c(-c3ccccc3)c3ccccc3oc-2c1](/scaffold/RRGYMPZNWMYZJT-UHFFFAOYSA-N/structure.svg)
[N+]=c1ccc2c(-c3ccccc3)c3ccccc3oc-2c139 chemicals, 4 rings(c2ccccc2)c2ccccc2)cc1](/scaffold/SVHQOIWIRUVWII-UHFFFAOYSA-N/structure.svg)
Tetraphenylborate39 chemicals, 4 rings
O=c1oc2ccccc2c2c1CCC239 chemicals, 3 rings
C(=Nn1cnnc1)c1ccccc139 chemicals, 2 rings
Pyrimidine, 2-(2-pyridinyl)-39 chemicals, 2 rings
1,1'-Binaphthyl39 chemicals, 4 rings
O=C1NC(=S)SC1=Cc1cnc2ccccn2c1=O38 chemicals, 3 rings
C1=NC=NCN1c1ccccc138 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2nc(SCc3ccccc3)[nH]c2[nH]1](/scaffold/DPACPINNZAEEGT-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2nc(SCc3ccccc3)[nH]c2[nH]138 chemicals, 3 rings
S=C1NC=CC(c2ccccc2)N138 chemicals, 2 rings
3-Phenyl-N-(2-phenylethyl)propanamide38 chemicals, 2 rings![Scaffold c1ccc(-c2cc(-c3ccccc3)[nH]n2)cc1](/scaffold/JXHKUYQCEJILEI-UHFFFAOYSA-N/structure.svg)
1H-Pyrazole, 3,5-diphenyl-38 chemicals, 3 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1ccccc1OC(=O)c1ccccc138 chemicals, 3 rings
1-Phenyl-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione38 chemicals, 3 rings
Benzyl nicotinate38 chemicals, 2 rings![Scaffold c1ccc2nc3c(nc2c1)[nH]c1ccccc13](/scaffold/LCKIWLDOHFUYDV-UHFFFAOYSA-N/structure.svg)
6H-Indolo(2,3-b)quinoxaline38 chemicals, 4 rings
c1ccc(CCCNCCc2ccccc2)cc138 chemicals, 2 rings
C1CCC2C3=C(CCC2C1)C1CCCC1CC338 chemicals, 4 rings