Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 721 to 780 of 15,838 scaffolds
2,3,4,5-Tetrahydro-1H-benzo(d)azepine38 chemicals, 2 rings
3-Phenyl-2-oxazolidinone38 chemicals, 2 rings
1-Phenylpiperidin-2-one38 chemicals, 2 rings
Decahydroquinoline38 chemicals, 2 rings
N-(Oxolan-2-ylmethyl)benzamide38 chemicals, 2 rings
O=C(c1ccccc1)c1ccc2cc(-c3ccccc3)ncn1238 chemicals, 4 rings
Benzamide, N-(2-pyrrolidinylmethyl)-38 chemicals, 2 rings
O=C1Cc2cc3n(c(=O)c2CO1)Cc1cc2ccccc2nc1-338 chemicals, 5 rings
Spiro(3.5)nonane38 chemicals, 2 rings
C(=Cc1ccc(Nc2ncnc(Nc3ccccc3)n2)cc1)c1ccc(Nc2ncnc(Nc3ccccc3)n2)cc138 chemicals, 6 rings![Scaffold O=c1[nH]c2ccccc2s1](/scaffold/YEDUAINPPJYDJZ-UHFFFAOYSA-N/structure.svg)
Benzothiazolone38 chemicals, 2 rings
3-Benzyl-2,3-dihydro-1,3-benzoxazol-2-one38 chemicals, 3 rings
(Cyclopropylmethoxy)benzene38 chemicals, 2 rings
10-Piperazinylpropylphenothiazine38 chemicals, 4 rings
1,2,3,4-Tetrahydro-1,8-naphthyridine38 chemicals, 2 rings
O=C(Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1)c1ccccc137 chemicals, 3 rings
7-Phenylpyrazolo[1,5-a]pyrimidine37 chemicals, 3 ringsO[PH](=O)OC3CCCCO3)O2)c(=O)[nH]1](/scaffold/AKKVBKIXAFLMCT-UHFFFAOYSA-N/structure.svg)
O=c1ccn(C2CCC(CO[PH](=O)O[PH](=O)OC3CCCCO3)O2)c(=O)[nH]137 chemicals, 3 rings
N-Phenyl-4-piperidinecarboxamide37 chemicals, 2 rings
O=C1NC(=S)SC1=Cc1c(N2CCNCC2)nc2ccccn2c1=O37 chemicals, 4 rings
4-Morpholineacetamide, N-phenyl-37 chemicals, 2 rings![Scaffold O=c1[nH]cnc2c1cnn2-c1ccccc1](/scaffold/GDZQGHGCKKWNAC-UHFFFAOYSA-N/structure.svg)
1,5-Dihydro-1-phenyl-4H-pyrazolo(3,4-d)pyrimidin-4-one37 chemicals, 3 rings
c1ccc(C2CCC2)nc137 chemicals, 2 rings
O=C(Oc1ccc(C=NNC(=S)Nc2ccccc2)cc1)c1ccccc137 chemicals, 3 rings
1,3-Cyclohexanedione37 chemicals, 1 ring
2-Phenyl-N-(1,3-thiazol-2-yl)acetamide37 chemicals, 2 rings
C(=CC1CCCC1)CCOc1ccccc137 chemicals, 2 rings
4-(5-Phenyl-1,2,4-oxadiazol-3-yl)pyridine37 chemicals, 3 rings![Scaffold O=C(Nc1nc2ccccc2[nH]1)c1ccccc1](/scaffold/LYLQJTSHZYGWBO-UHFFFAOYSA-N/structure.svg)
N-(1H-1,3-Benzodiazol-2-yl)benzamide37 chemicals, 3 rings
N-Phenylmorpholine-4-carboxamide37 chemicals, 2 rings
Dihydrouracil37 chemicals, 1 ring
N-(4-Pyridyl)benzamide37 chemicals, 2 rings
S=C(Nc1ccccc1)N1CCNCC137 chemicals, 2 rings
1H-Pyrazole, 1-benzoyl-37 chemicals, 2 rings
2-Benzylsulfanyl-4,5-dihydro-1H-imidazole37 chemicals, 2 rings
C1=CC2OC3CCC(C2CC1)C31CO137 chemicals, 4 rings![Scaffold O=c1ccn(Cc2ccccc2)c(=O)[nH]1](/scaffold/VYBPQVFJJKEBLA-UHFFFAOYSA-N/structure.svg)
1-Benzyluracil37 chemicals, 2 rings
Benzylphthalimide37 chemicals, 3 rings
1,2,4-Triazolo(4,3-b)pyridazine37 chemicals, 2 rings
1-Phenyl-1,2,3,4-tetrahydronaphthalene37 chemicals, 3 rings
Malonanilide37 chemicals, 2 rings
N-(1,3-Benzodioxol-5-ylmethyl)benzamide37 chemicals, 3 rings
C1=CC(c2ccccc2)n2ncnc2N137 chemicals, 3 rings
O=C(CNS(=O)(=O)c1ccccc1)Nc1ccccc136 chemicals, 2 rings
Cycloheptanone36 chemicals, 1 ring
Benz(a)anthracene36 chemicals, 4 rings![Scaffold c1ccc2c(c1)[nH]c1ncnnc12](/scaffold/FUXGNLJTRBGPHI-UHFFFAOYSA-N/structure.svg)
5H-[1,2,4]Triazino[5,6-b]indole36 chemicals, 3 rings
3-Phenyl-2,1-benzisoxazole36 chemicals, 3 rings
Diphenylacetylene36 chemicals, 2 rings
Bicyclo[2.1.1]hexane36 chemicals, 3 rings
c1ccc(Cn2ccc(-c3ccccc3)n2)cc136 chemicals, 3 rings
2-Phenyl-1,3-dioxane36 chemicals, 2 rings![Scaffold c1ccc(-c2cn[nH]n2)cc1](/scaffold/LUEYUHCBBXWTQT-UHFFFAOYSA-N/structure.svg)
4-Phenyl-1H-1,2,3-triazole36 chemicals, 2 rings
Coumaranone36 chemicals, 2 rings![Scaffold S=c1[nH]ncn1-c1ccccc1](/scaffold/PUGUFBAPNSPHHY-UHFFFAOYSA-N/structure.svg)
4-Phenyl-4H-1,2,4-triazole-3-thiol36 chemicals, 2 rings
N-Cyclohexylaniline36 chemicals, 2 rings![Scaffold O=C(CSc1nc(=O)cc[nH]1)Nc1ccccc1](/scaffold/UEUKCLFBPXWWLO-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc(=O)cc[nH]1)Nc1ccccc136 chemicals, 2 rings![Scaffold c1ccc(OCCSc2nc3ccccc3[nH]2)cc1](/scaffold/UEYUFQWEHMSHIX-UHFFFAOYSA-N/structure.svg)
2-[(2-Phenoxyethyl)sulfanyl]-1H-1,3-benzodiazole36 chemicals, 3 rings![Scaffold c1cc2n[nH]cc2cn1](/scaffold/WCXFPLXZZSWROM-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo[4,3-c]pyridine36 chemicals, 2 rings
N-(1-Naphthylmethylene)aniline36 chemicals, 3 rings