Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 781 to 840 of 15,838 scaffolds
N-[(Furan-2-yl)methyl]benzenesulfonamide36 chemicals, 2 rings
O=c1cccc2c(c1)CCCc1ccccc1-236 chemicals, 3 rings![Scaffold O=c1cc(Sc2ccccc2)[nH]c(=O)[nH]1](/scaffold/ZNLSBGQCJIWHCT-UHFFFAOYSA-N/structure.svg)
6-Phenyl-thiouracil36 chemicals, 2 rings
6,7-Dihydro-5H-pyrrolo(1,2-a)imidazole36 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(-c3ccccc3)nc2[nH]1](/scaffold/ACCCXSZCOGNLFL-UHFFFAOYSA-N/structure.svg)
8-Phenylxanthine35 chemicals, 3 rings![Scaffold O=c1ccnc2cc[nH]n12](/scaffold/BUEFDJQUUGMUJO-UHFFFAOYSA-N/structure.svg)
Pyrazolo[1,5-a]pyrimidin-7-ol35 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(NN=Cc3ccccc3)nc2[nH]1](/scaffold/CHHJWHRZURXTFZ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(NN=Cc3ccccc3)nc2[nH]135 chemicals, 3 rings
1-Naphthanilide35 chemicals, 3 rings
3-Phenyl-3H-diazirine35 chemicals, 2 rings
Cyclododecane35 chemicals, 1 ring![Scaffold O=c1nc2[nH]c3ccccc3nc-2c(=O)[nH]1](/scaffold/HAUGRYOERYOXHX-UHFFFAOYSA-N/structure.svg)
Alloxazine35 chemicals, 3 rings
4H,5H,6H,7H-Pyrazolo(1,5-a)pyridine35 chemicals, 2 rings
C1=CC(c2ccc(-c3ccccc3)o2)C=CN135 chemicals, 3 rings
c1ccc2c(c1)CC1NCCC23CCCCC1335 chemicals, 4 rings
O=C(COc1ccccc1)NN=Cc1cccc(OC(=O)c2ccccc2)c135 chemicals, 3 rings![Scaffold O=c1ccnc(-c2ccccc2)[nH]1](/scaffold/JJXBLRJIMBFLMY-UHFFFAOYSA-N/structure.svg)
2-Phenylpyrimidin-4-ol35 chemicals, 2 rings![Scaffold c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc1](/scaffold/JTTNDRXETJGQKP-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc135 chemicals, 3 rings![Scaffold c1ncc2[nH]ccc2n1](/scaffold/KDOPAZIWBAHVJB-UHFFFAOYSA-N/structure.svg)
Pyrrolopyrimidine35 chemicals, 2 rings![Scaffold c1cc2c[nH]nc2cn1](/scaffold/KNYHISBJRQVMAZ-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo[3,4-c]pyridine35 chemicals, 2 rings
O=C(CN1C(=O)C(=C2SC(=S)N(Cc3ccccc3)C2=O)c2ccccc21)Nc1ccccc135 chemicals, 5 rings
N-Cyclopropylbenzenesulfonamide35 chemicals, 2 rings
1,2,3,4-Tetrahydroacridine35 chemicals, 3 rings
2-Phenyl-1,3,5-triazine35 chemicals, 2 rings
7-Azabicyclo(2.2.1)heptane35 chemicals, 2 rings![Scaffold c1csc(-c2cc[nH]n2)c1](/scaffold/TVNDPZYOQCCHTJ-UHFFFAOYSA-N/structure.svg)
5-(2-Thienyl)pyrazole35 chemicals, 2 rings
Benzocyclobutene35 chemicals, 2 rings![Scaffold C1=C2c3cccc4[nH]cc(c34)CC2NCC1](/scaffold/VUEGRGTYEAPQFU-UHFFFAOYSA-N/structure.svg)
9,10-Ergolene35 chemicals, 4 rings
c1ccc2c(c1)CC1NCCc3cc4c(c-2c31)OCO435 chemicals, 5 rings![Scaffold c1ccc(CNc2nnn[nH]2)cc1](/scaffold/XONYMCKGFMQQFX-UHFFFAOYSA-N/structure.svg)
5-Benzylaminotetrazole35 chemicals, 2 rings
O=C(Nc1ccc(N2CCNCC2)cc1)c1ccccc135 chemicals, 3 rings
O=c1ccc2c(-c3ccccc3)c3ccccc3oc-2c135 chemicals, 4 ringsc1ccccc1](/scaffold/ASUOLLHGALPRFK-UHFFFAOYSA-N/structure.svg)
Diphenylphosphine oxide34 chemicals, 2 rings
2-Phenyl-2,3-dihydroquinazolin-4(1H)-one34 chemicals, 3 rings
Tetrahydroprotoberberine34 chemicals, 4 rings
3-(Furan-2-yl)-N-phenylpropanamide34 chemicals, 2 rings
1-Benzoyl-1,2,3,4-tetrahydroquinoline34 chemicals, 3 rings
O=S(=O)(NCC1CCCO1)c1ccccc134 chemicals, 2 rings
Benzalazine34 chemicals, 2 rings
Bicyclo(3.1.1)hept-2-ene34 chemicals, 3 rings![Scaffold O=c1[nH]nnc2ccccc12](/scaffold/DMSSTTLDFWKBSX-UHFFFAOYSA-N/structure.svg)
1,2,3-Benzotriazin-4-one34 chemicals, 2 rings
6-Azaspiro[2.5]octane34 chemicals, 2 rings
3-Benzylpyrrolidine34 chemicals, 2 rings
2-(Piperidin-1-yl)pyrimidine34 chemicals, 2 rings![Scaffold c1ccc(CSc2nc3ccccc3[nH]2)cc1](/scaffold/IJINDUSMSVDESS-UHFFFAOYSA-N/structure.svg)
2-Benzylthiobenzimidazole34 chemicals, 3 rings
3-(Phenylamino)-2-cyclohexen-1-one34 chemicals, 2 rings
O=C1NC(c2ccccc2)C(=Cc2ccc(OCc3ccccc3)cc2)C1=O34 chemicals, 4 rings
3-Benzyloxypyridine34 chemicals, 2 rings
O=C(CSc1nncs1)Nc1ccccc134 chemicals, 2 rings
Pterocarpan34 chemicals, 4 rings
3-Azabicyclo[3.2.0]heptane34 chemicals, 2 rings
2-Thiazoline, 2-anilino-34 chemicals, 2 rings
Spiropentane34 chemicals, 2 rings
2-Phenylimidazo[1,2-a]pyrimidine34 chemicals, 3 rings
O=C(Nc1ccccc1)c1cc(N=Nc2ccccc2)c2ccccc2c134 chemicals, 4 rings
O=S(=O)(Nc1cnc2ccccc2n1)c1ccccc134 chemicals, 3 rings![Scaffold O=C(CSc1nnc(Cc2ccccc2)c(=O)[nH]1)Nc1ccccc1](/scaffold/QUNPIWUWTCXBCU-UHFFFAOYSA-N/structure.svg)
2-[(6-Benzyl-5-hydroxy-1,2,4-triazin-3-yl)sulfanyl]-N-phenylacetamide34 chemicals, 3 rings
2-Phenylquinoxaline34 chemicals, 3 rings
5,6,7,8-Tetrahydroquinazoline34 chemicals, 2 rings
N-3-Pyridylbenzenesulfonamide34 chemicals, 2 rings
Pyrimidine, 2,4-diphenyl-34 chemicals, 3 rings