Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 961 to 1,020 of 15,838 scaffolds
9-Benzyl-9H-purine30 chemicals, 3 rings
4,4'-Bipyridine30 chemicals, 2 rings
N-(1,2-Oxazol-3-yl)benzenesulfonamide30 chemicals, 2 rings
5-Oxa-2-azaspiro[3.4]octane30 chemicals, 2 rings![Scaffold c1ccc(CNc2ncnc3[nH]cnc23)cc1](/scaffold/NWBJYWHLCVSVIJ-UHFFFAOYSA-N/structure.svg)
Benzylaminopurine30 chemicals, 3 rings
c1ncc(B2OCCO2)s130 chemicals, 2 rings
N-Phenyl-1-benzothiophene-2-carboxamide30 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(nc(N3CCNCC3)n2Cc2ccccc2)[nH]1](/scaffold/QVRTZFVIRFITBG-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc(N3CCNCC3)n2Cc2ccccc2)[nH]130 chemicals, 4 rings
O=C(NN=Cc1ccccc1)c1ccccc1OCc1ccccc130 chemicals, 3 rings
O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCCc1ccccc130 chemicals, 2 rings
N-Benzylfuran-2-carboxamide30 chemicals, 2 rings
O=C(CCn1nnc2ccccc21)NN=Cc1ccccc130 chemicals, 3 rings
O=C1CCC2C1CCC1C3CCCCC3=CCC2130 chemicals, 4 rings![Scaffold O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1](/scaffold/XHWZVQUKSBVLDH-UHFFFAOYSA-N/structure.svg)
O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc130 chemicals, 3 rings![Scaffold S=c1[nH]c2ccccc2s1](/scaffold/YXIWHUQXZSMYRE-UHFFFAOYSA-N/structure.svg)
2-Mercaptobenzothiazole30 chemicals, 2 rings
O=c1ccn(-c2ccccc2)nc130 chemicals, 2 rings
c1ccc(-c2nnc3cccnn23)cc130 chemicals, 3 rings
1,2-Diphenylpyrrole30 chemicals, 3 rings
Acenaphthene29 chemicals, 3 rings
Phenyl 4-(2-pyridyl)piperazinyl ketone29 chemicals, 3 rings
1-(Thiophen-2-ylsulfonyl)piperidine29 chemicals, 2 rings
O=C1C=C2CCC3C4CCC(=O)C4CCC3C2CC129 chemicals, 4 rings
C1CC2(C1)CCOCC229 chemicals, 2 rings
Spiro(3.4)octane29 chemicals, 2 rings![Scaffold O=c1cc(-c2ccccc2)[nH]c2ccccc12](/scaffold/JGABMVVOXLQCKZ-UHFFFAOYSA-N/structure.svg)
2-Phenyl-4-oxohydroquinoline29 chemicals, 3 rings
2-Phenoxypyrazine29 chemicals, 2 rings![Scaffold O=c1ccnc2c(-c3ccccc3)c[nH]n12](/scaffold/LQOZGZQLNDEHLB-UHFFFAOYSA-N/structure.svg)
3-Phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one29 chemicals, 3 rings
Thieno(3,2-c)pyridine29 chemicals, 2 rings
2,3,4,5-Tetrahydro-1H-1,4-benzodiazepine29 chemicals, 2 rings
4-Benzhydrylidenecyclohexa-2,5-dien-1-one29 chemicals, 3 rings
5-Phenyl-3-pyridin-3-yl-1,2,4-oxadiazole29 chemicals, 3 rings
O=c1c(=Cc2ccccc2)sc2n1C(c1cccs1)C=CN=229 chemicals, 4 ringsO1)O[PH](=O)OCC1CCC([n+]2ccccc2)O1](/scaffold/NEQSZHPXWRKWHT-UHFFFAOYSA-N/structure.svg)
O=[PH](OCC1CCC(n2cnc3cncnc32)O1)O[PH](=O)OCC1CCC([n+]2ccccc2)O129 chemicals, 5 rings
3-Phenyl-8-azabicyclo[3.2.1]octane29 chemicals, 3 rings
Benzene, (cyclohexyloxy)-29 chemicals, 2 rings
1,4:3,6-Dianhydro-2,5-dideoxyhexitol29 chemicals, 2 rings
7-[(Oxan-2-yl)oxy]-2H-1-benzopyran-2-one29 chemicals, 3 rings
C1CCC(OC2CCOCC2)OC129 chemicals, 2 rings
O=C(c1ccccc1)c1ccc2ccccn1229 chemicals, 3 rings
S=c1sccn1-c1ccccc129 chemicals, 2 rings
N-Phenyl-2-(1-phenyltetrazol-5-yl)sulfanylacetamide29 chemicals, 3 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals, 2 rings
5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)pyrazine29 chemicals, 2 rings
N-(1-Naphthyl)benzenesulfonamide29 chemicals, 3 rings![Scaffold O=C(Oc1cc[nH]c(=O)c1)c1ccccc1](/scaffold/VTWNRLAJNCIEML-UHFFFAOYSA-N/structure.svg)
O=C(Oc1cc[nH]c(=O)c1)c1ccccc129 chemicals, 2 rings
N-(1,2-Oxazol-3-yl)benzamide29 chemicals, 2 rings
RefChem:35714029 chemicals, 4 rings![Scaffold O=C(Nc1ccccc1)c1ccc[nH]c1=O](/scaffold/XSCBGRZRDXWZGE-UHFFFAOYSA-N/structure.svg)
2-Oxo-N-phenyl-1,2-dihydropyridine-3-carboxamide29 chemicals, 2 rings
O=C1NC2CSCC2N129 chemicals, 2 rings
3-Phenyl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine29 chemicals, 3 rings
O=C(NCNc1ccccc1)c1ccccc129 chemicals, 2 rings
N-Phenyl-1-(2-phenylethyl)-4-piperidinamine29 chemicals, 3 rings
N-(1,3-Benzothiazol-2-yl)-2-thiophenecarboxamide29 chemicals, 3 rings
N,N'-Dibenzoylpiperazine28 chemicals, 3 rings
N,1-diphenylmethanesulfonamide28 chemicals, 2 rings
N-(Pyridin-3-ylmethyl)aniline28 chemicals, 2 rings
N-Phenyl-4-isoxazolecarboxamide28 chemicals, 2 rings
2-Phenylazetidine28 chemicals, 2 rings
1,4-Diphenylpyrazole28 chemicals, 3 rings
1-(Pyridin-3-yl)piperazine28 chemicals, 2 rings