Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,681 to 1,740 of 15,838 scaffolds
4H-1,3-Benzodioxin19 chemicals, 2 rings
5H-Thiazolo(3,2-a)pyrimidin-5-one19 chemicals, 2 rings![Scaffold O=c1cn[nH]c2ccccc12](/scaffold/UFMBERDMCRCVSM-UHFFFAOYSA-N/structure.svg)
4-Cinnolinol19 chemicals, 2 rings![Scaffold c1ccc2c(c1)CC[n+]1cc3ccccc3cc1-2](/scaffold/UICBHOXXGLYZJH-UHFFFAOYSA-N/structure.svg)
Protoberberine19 chemicals, 4 rings
1-Benzoyl-1H-benzotriazole19 chemicals, 3 rings
N-(4-Pyridinylmethyl)benzamide19 chemicals, 2 rings
2,3'-Bipyridine19 chemicals, 2 rings
C(CCN1CCNCC1)=C1c2ccccc2Sc2ccccc2119 chemicals, 4 rings
6-Azabicyclo(3.2.1)octane19 chemicals, 2 rings![Scaffold c1cnc2n[nH]nc2c1](/scaffold/VQNDBXJTIJKJPV-UHFFFAOYSA-N/structure.svg)
1H-1,2,3-Triazolo(4,5-b)pyridine19 chemicals, 2 rings
N-((1,3,5-Triazin-2-yl)carbamoyl)benzenesulfonamide19 chemicals, 2 rings
O=C(COc1ccc2ccccc2c1)NN=Cc1ccc(OC(=O)c2ccccc2)cc119 chemicals, 4 rings![Scaffold c1ccc2c(-c3cscn3)c[nH]c2c1](/scaffold/WMACHIODVOSLNK-UHFFFAOYSA-N/structure.svg)
c1ccc2c(-c3cscn3)c[nH]c2c119 chemicals, 3 rings
O=S(=O)(c1ccccc1)N1CCOc2ccccc2119 chemicals, 3 rings
7-(2-Oxo-2-phenylethoxy)-2H-chromen-2-one19 chemicals, 3 rings
2-((1-(Furan-2-ylmethyl)-1H-imidazol-2-yl)thio)-N-phenylacetamide19 chemicals, 3 rings
O=S(=O)(c1ccccc1)N1CCN=C1c1ccccc119 chemicals, 3 rings
O=C(CCc1ccccc1)OC1C=C2CC(=O)C3CCC4OCC4C3C(OC(=O)c3ccccc3)C(C2)C119 chemicals, 6 rings
1-(Pyridin-2-yl)-1,4-diazepane19 chemicals, 2 rings
3-(1H-Pyrazol-1-yl)pyridine19 chemicals, 2 rings
4-Phenylcyclohexanone19 chemicals, 2 rings
O=S(=O)(c1ccccc1)c1coc(-c2ccccc2)n119 chemicals, 3 rings
1,2,4-Triazine, 5-phenyl-19 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(N3CCN(c4ccccc4)CC3)nc2[nH]1](/scaffold/YWSMDRVDUFKXJL-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(N3CCN(c4ccccc4)CC3)nc2[nH]119 chemicals, 4 rings
1,2,3,4-Tetrahydropyrrolo(1,2-a)pyrazine19 chemicals, 2 rings
N-(Phenylsulfonyl)benzamide19 chemicals, 2 rings
1-(Phenylacetyl)piperazine19 chemicals, 2 rings
O=C1C=C(C2CCC3C2CCC2C4CCC(OC5CCC(OC6CCC(OC7CCCCO7)CO6)CO5)CC4CCC23)CO119 chemicals, 8 rings
N-(2-Anilino-2-oxoethyl)benzamide19 chemicals, 2 rings
C1OCC2CC1219 chemicals, 2 rings
Spiro(3.3)heptan-2-one18 chemicals, 2 rings
5-Phenyl-1,3-oxazolidin-2-one18 chemicals, 2 rings
9-Azabicyclo(3.3.1)nonane18 chemicals, 2 rings
c1coc(-c2cscn2)c118 chemicals, 2 rings
C1=CCC2c3ccccc3OCC2C118 chemicals, 3 rings
2,5-Dioxopyrrolidin-1-yl benzoate18 chemicals, 2 rings![Scaffold c1n[nH]c2c1COCC2](/scaffold/BVXUWXXNYXLXCQ-UHFFFAOYSA-N/structure.svg)
1H,4H,6H,7H-Pyrano(4,3-c)pyrazole18 chemicals, 2 rings
2-(Azetidin-1-yl)pyridine18 chemicals, 2 rings![Scaffold c1ccc(CCc2ncn[nH]2)cc1](/scaffold/CMIDWHYBJLVBKP-UHFFFAOYSA-N/structure.svg)
c1ccc(CCc2ncn[nH]2)cc118 chemicals, 2 rings
Spiro(4.5)decane18 chemicals, 2 rings
O=C(Nc1ccccc1)C1CCN(S(=O)(=O)c2ccccc2)CC118 chemicals, 3 rings![Scaffold O=c1[nH]sc2ccccc12](/scaffold/DMSMPAJRVJJAGA-UHFFFAOYSA-N/structure.svg)
1,2-Benzisothiazol-3(2H)-one18 chemicals, 2 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccco1](/scaffold/DRVAQVMLKHKTRJ-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccco118 chemicals, 3 rings
4-(Phenylimino)-2,5-cyclohexadien-1-one18 chemicals, 2 rings
(4-(6-Morpholinopyridazin-3-yl)piperazin-1-yl)(phenyl)methanone18 chemicals, 4 rings![Scaffold O=c1[nH]cnc2[nH]ccc12](/scaffold/FBMZEITWVNHWJW-UHFFFAOYSA-N/structure.svg)
7-Deazahypoxanthine18 chemicals, 2 rings
C=C1c2ccccc2COc2ccccc2118 chemicals, 3 rings
O=C(Nc1ccccc1)c1cc2cccnc2s118 chemicals, 3 rings
N-Phenyl-2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide18 chemicals, 3 rings![Scaffold O=C(N=c1[nH]ccs1)c1ccco1](/scaffold/FWBKTKWUXLKDLK-UHFFFAOYSA-N/structure.svg)
N-(1,3-Thiazol-2-yl)furan-2-carboxamide18 chemicals, 2 rings
O=C(NN=Cc1ccccc1)c1ccoc118 chemicals, 2 rings![Scaffold c1ccc(-c2ccccc2-c2nn[nH]n2)cc1](/scaffold/HLAYLOOJBAJIRU-UHFFFAOYSA-N/structure.svg)
5-Biphenyl-2-yl-1H-tetrazole18 chemicals, 3 rings
C1CC2(C1)CC21CCC118 chemicals, 3 rings
Benzamide, N-(2-benzoylphenyl)-18 chemicals, 3 rings
c1ccc(CCCCNCCc2ccccc2)cc118 chemicals, 2 rings
5-Phenylbarbituric acid18 chemicals, 2 rings
c1ccc(N=Nc2ccc(N=Nc3cccc4ccccc34)cc2)cc118 chemicals, 4 rings![Scaffold O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1ccccc1](/scaffold/ISOCOTURUNJAQI-UHFFFAOYSA-N/structure.svg)
O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1ccccc118 chemicals, 3 rings
11-Oxo-N-phenyl-1-azatricyclo[6.3.1.0^{4,12}]dodeca-4(12),5,7-triene-6-sulfonamide18 chemicals, 4 rings
2-Phenyl-1,3,6,2-dioxazaborocane-4,8-dione18 chemicals, 2 rings