Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 1,801 to 1,860 of 15,838 scaffolds
![Scaffold O=c1ccn(C2CCC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]1](/scaffold/XLZWZKQCXGAFRX-UHFFFAOYSA-N/structure.svg)
O=c1ccn(C2CCC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]118 chemicals, 5 rings
2-Cyclopropylfuran18 chemicals, 2 rings
O=C(CCN1C(=O)c2ccccc2C1=O)Nc1ccccc118 chemicals, 3 rings
N-5-Quinolinylbenzamide18 chemicals, 3 rings
O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1ccco118 chemicals, 4 rings
O=C(Cc1ccccc1)Nc1cc2c(s1)CNCC218 chemicals, 3 rings
c1noc2c1CCCC218 chemicals, 2 rings
1-(Phenylsulfonyl)-1H-benzotriazole18 chemicals, 3 rings![Scaffold O=C(Cn1cnc2[nH]c(=O)[nH]c(=O)c21)Nc1ccccc1](/scaffold/ZWJKCVAAPQWJQO-UHFFFAOYSA-N/structure.svg)
O=C(Cn1cnc2[nH]c(=O)[nH]c(=O)c21)Nc1ccccc118 chemicals, 3 rings
O=C1CNC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)CCSSCC(C(=O)N2CCCC2)NC(=O)CN118 chemicals, 4 rings
Furo[2,3-c]pyridine18 chemicals, 2 rings
O=C(NN=Cc1cccc(OCc2ccccc2)c1)c1ccccc117 chemicals, 3 rings![Scaffold O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1ccccc1](/scaffold/AJRIOXSLDWQDNT-UHFFFAOYSA-N/structure.svg)
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-phenylacetamide17 chemicals, 3 rings
Diazoaminobenzene17 chemicals, 2 rings
O=C(CNC(=O)c1ccccc1)NN=CC=Cc1ccccc117 chemicals, 2 rings![Scaffold O=C(c1ccc2c(=O)[nH]c(=O)[nH]c2c1)N1CCN(c2ccccc2)CC1](/scaffold/AMOMFUFPSTXQCC-UHFFFAOYSA-N/structure.svg)
O=C(c1ccc2c(=O)[nH]c(=O)[nH]c2c1)N1CCN(c2ccccc2)CC117 chemicals, 4 rings![Scaffold S=c1[nH]ccn1Cc1ccccc1](/scaffold/AOCFYLGZVCPZML-UHFFFAOYSA-N/structure.svg)
1-Benzyl-1H-imidazole-2-thiol17 chemicals, 2 rings
O=C(C=Cc1ccc(-c2ccccc2)o1)c1ccccc117 chemicals, 3 rings
O=C1NC(=Nc2ccccc2)SC1=Cc1ccccc117 chemicals, 3 rings
3(2H)-Pyridazinone, 4,5-dihydro-6-(2-phenylethenyl)-17 chemicals, 2 rings
2-Styrylpyridine17 chemicals, 2 rings
3-Benzylpiperidine17 chemicals, 2 rings![Scaffold S=c1[nH]nc(Nc2ccccc2)s1](/scaffold/BOJLJKMUGYYKCZ-UHFFFAOYSA-N/structure.svg)
1,3,4-Thiadiazole-2(3H)-thione, 5-anilino-17 chemicals, 2 rings
4-(Piperazin-1-yl)pyrimidine17 chemicals, 2 rings
1-Pyrrolidineacetamide, N-phenyl-17 chemicals, 2 rings
N-Phenyl-2,3-dihydro-1,4-benzodioxine-6-carboxamide17 chemicals, 3 rings
c1ccc(OCc2nccs2)cc117 chemicals, 2 rings
Benzenesulfonamide, N-(2-thienylmethyl)-17 chemicals, 2 rings
O=c1c(OC2OCCCC2OC2CCCCO2)c(-c2ccccc2)oc2ccccc1217 chemicals, 5 rings
2,3-Dihydro-1H-pyrrolizine17 chemicals, 2 rings
1-Phenyl-3-(3-pyridylmethyl)urea17 chemicals, 2 rings
c1ccc(CNc2ccc(N3CCOCC3)cc2)cc117 chemicals, 3 rings
1,1'-Bicyclobutyl17 chemicals, 2 rings![Scaffold O=C(C(=O)N1CCN(c2ccccc2)CC1)c1c[nH]c2ccccc12](/scaffold/DHSZCAQWNANREP-UHFFFAOYSA-N/structure.svg)
Piperazine, 1-(1H-indol-3-yloxoacetyl)-4-phenyl-17 chemicals, 4 rings
2,3-Diphenyl-4-thiazolidinone17 chemicals, 3 rings
1-Phenyl-2-(phenylsulphonyl)ethan-1-one17 chemicals, 2 rings
N-Phenylrhodanine17 chemicals, 2 rings
4,5,6,7-Tetrahydro-1-benzofuran-4-one17 chemicals, 2 rings
N-(3-Morpholin-4-ylpropyl)benzamide17 chemicals, 2 rings
1,2,3-Benzothiadiazole17 chemicals, 2 rings
O=C(NCC1CC2CCC1C2)c1ccccc117 chemicals, 3 rings
N-(4-Pyrrolidin-1-ylsulfonylphenyl)benzamide17 chemicals, 3 rings
(2-Norbornyl)benzene17 chemicals, 3 rings
Benzothiophene 1,1-dioxide17 chemicals, 2 rings![Scaffold c1ccc(CNc2ccc3[nH]cnc3c2)cc1](/scaffold/FSRYAPDLWNOBIU-UHFFFAOYSA-N/structure.svg)
c1ccc(CNc2ccc3[nH]cnc3c2)cc117 chemicals, 3 rings
N-Phenyl-1-(phenylmethyl)-4-piperidinamine17 chemicals, 3 rings
2-(2-Thiazolyl)pyridine17 chemicals, 2 rings![Scaffold S=c1[nH]nnn1-c1ccccc1](/scaffold/GGZHVNZHFYCSEV-UHFFFAOYSA-N/structure.svg)
1-Phenyl-5-mercaptotetrazole17 chemicals, 2 rings
C1CC2OC2C117 chemicals, 2 rings
5-Oxo-N-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxamide17 chemicals, 3 rings
2-N,4-N-diphenylpyrimidine-2,4-diamine17 chemicals, 3 rings
N-(Benzylcarbamothioyl)benzamide17 chemicals, 2 rings
c1ccc(-n2ccc(-c3cccs3)n2)cc117 chemicals, 3 rings
N-(1,3-Benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide17 chemicals, 4 rings
N-(5-(5,6-Dihydro-1,4-dioxin-2-yl)-1,3,4-oxadiazol-2-yl)benzamide17 chemicals, 3 rings
Fluoranthene17 chemicals, 4 rings![Scaffold c1cnc2[nH]ccc2n1](/scaffold/HFTVJMFWJUFBNO-UHFFFAOYSA-N/structure.svg)
5H-Pyrrolo[2,3-b]pyrazine17 chemicals, 2 rings![Scaffold c1cc(C2CCC2)[nH]n1](/scaffold/HLPBQDVLMHJKRN-UHFFFAOYSA-N/structure.svg)
3-Cyclobutyl-1H-pyrazole17 chemicals, 2 rings
2-(Benzenesulfonyl)-N-(1,3-benzothiazol-2-yl)acetamide17 chemicals, 3 rings
N-[2-(Benzylsulfamoyl)ethyl]benzamide17 chemicals, 2 rings