Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,221 to 2,280 of 15,838 scaffolds
O=C(COc1ccccc1)N1CCN(C(=O)c2ccccc2)CC115 chemicals, 3 rings
N-Benzyl-2-(4-oxopyrido[1,2-a][1,3,5]triazin-2-yl)sulfanylacetamide15 chemicals, 3 rings
3-(Piperidin-1-yl)pyridine15 chemicals, 2 rings
S=C(NCCCN1CCOCC1)Nc1ccccc115 chemicals, 2 rings
c1ccc(Sc2ccncn2)cc115 chemicals, 2 rings
4-(1H-1,2,3-Triazol-1-yl)piperidine15 chemicals, 2 rings![Scaffold c1ccc(C2NCCc3[nH]cnc32)cc1](/scaffold/SHIJOLLBBCZWON-UHFFFAOYSA-N/structure.svg)
4-Phenyl-1H,4H,5H,6H,7H-imidazo[4,5-c]pyridine15 chemicals, 3 rings![Scaffold O=C(Nc1ccc2[nH]cnc2c1)c1ccccc1](/scaffold/SLVMHTJVJDNNJB-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccc2[nH]cnc2c1)c1ccccc115 chemicals, 3 rings
1-Phenethylimidazole15 chemicals, 2 rings
N-[2-(1-Cyclohexen-1-yl)ethyl]benzamide15 chemicals, 2 rings
O=C(CCNc1ccccc1)c1ccc2c(c1)OCO215 chemicals, 3 rings
2-Phenylnaphthalene15 chemicals, 3 rings
5-Phenyl-3-(phenylamino)cyclohex-2-EN-1-one15 chemicals, 3 rings
5-Benzylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-dione15 chemicals, 2 rings
3-(2-Oxo-2-phenylethyl)-4(3H)-quinazolinone15 chemicals, 3 rings
O=C1OCC=C1CCCCCCCCCCCCCC1CCC(C2CCCO2)O115 chemicals, 3 rings
1-Phenyl-2-(1H-pyrazol-1-yl)ethanone15 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(CNCc3ccccc3)nc2[nH]1](/scaffold/UVIPRNPUIHSMKT-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(CNCc3ccccc3)nc2[nH]115 chemicals, 3 rings![Scaffold c1coc(-c2nc3ccccc3[nH]2)c1](/scaffold/UYJUZNLFJAWNEZ-UHFFFAOYSA-N/structure.svg)
Fuberidazole15 chemicals, 3 rings
3-Benzyl-3,6-dihydropyrazine-2,5-diol15 chemicals, 2 rings
O=C1CCCC(CCC2CC=CC3=CCCCC32)O115 chemicals, 3 rings
N-[Phenyl(phenylformamido)methyl]benzamide15 chemicals, 3 rings![Scaffold O=C(CSc1nccc(=O)[nH]1)c1ccccc1](/scaffold/VJLORWRQIUWAPI-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nccc(=O)[nH]1)c1ccccc115 chemicals, 2 rings
O=C(NN=Cc1ccccc1)c1ccccn115 chemicals, 2 rings
2-(5-Phenyl-1,2,4-oxadiazol-3-yl)pyridine15 chemicals, 3 rings
O=c1ccn(C2CC2)c2ccccc1215 chemicals, 3 rings
1-(Thiophen-2-ylsulfonyl)-1,2,3,4-tetrahydroquinoline15 chemicals, 3 rings
O=C(OC1Cc2ccccc2OC1c1ccccc1)c1ccccc115 chemicals, 4 rings
1-Phenyl-4-piperidinone15 chemicals, 2 rings![Scaffold O=c1nccc(SCc2ccccc2)[nH]1](/scaffold/VWIIEGVFHWRXEZ-UHFFFAOYSA-N/structure.svg)
O=c1nccc(SCc2ccccc2)[nH]115 chemicals, 2 rings
N-Benzoyl-N'-(3-pyridinyl)thiourea15 chemicals, 2 rings
O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1cccs115 chemicals, 4 rings
N-(Benzo[d][1,3]dioxol-5-yl)benzenesulfonamide15 chemicals, 3 rings
2,3,3a,4,7,7a-Hexahydro-4,7-methano-1H-indene15 chemicals, 3 rings
n-Benzyl-2-(pyridin-2-yl)ethanamine15 chemicals, 2 rings
Cyclohexane, cyclopropyl-15 chemicals, 2 rings
N,2-diphenyl-2-(phenylsulfanyl)acetamide15 chemicals, 3 rings
3-Azabicyclo[3.3.1]nonane15 chemicals, 2 rings
O=C1NC(=S)SC1=C1C(=O)N(Cc2ccccc2)c2ccccc2115 chemicals, 4 rings
O=C1SC(Nc2ccccc2)C(=O)N1Cc1ccccc115 chemicals, 3 rings
Hydrazobenzene15 chemicals, 2 rings
2-((1-(2-Morpholinoethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-phenylacetamide15 chemicals, 4 rings
2-Phenoxy-N-(3-pyridinyl)acetamide15 chemicals, 2 rings
O=C(COc1ccc(OCc2ccccc2)cc1)NN=Cc1ccccc115 chemicals, 3 rings
2-Furyl 4-benzylpiperazinyl ketone15 chemicals, 3 rings
N-Benzylpyridine-4-carboxamide15 chemicals, 2 rings
C1=CC2CCC3C4CCCCC4=CCC3C2C115 chemicals, 4 rings
3-Morpholin-4-yl-N-phenylpropanamide15 chemicals, 2 rings![Scaffold O=C(C=Cc1ccccc1)NCCc1c[nH]c2ccccc12](/scaffold/YSNGDZDGGGVGHU-UHFFFAOYSA-N/structure.svg)
MS-640815 chemicals, 3 rings
O=C(CSc1ccccn1)c1ccccc115 chemicals, 2 rings
O=C1NC(c2cccnc2)C(=Cc2ccccc2)C1=O15 chemicals, 3 rings
O=c1ccn(-c2ccccc2)c2cc(N3CCNCC3)ccc1215 chemicals, 4 rings
N-(1,3-Thiazol-2-yl)thiophene-2-carboxamide15 chemicals, 2 rings
Methylenedinaphthalene15 chemicals, 4 rings
3-Phenylquinoline15 chemicals, 3 rings
1,3-Diphenyl-4,5-dihydro-1H-pyrazole15 chemicals, 3 rings
c1ccc(-c2nccnn2)cc114 chemicals, 2 rings
C1OC2(CS1)CN1CCC2CC114 chemicals, 4 rings
5H,6H,7H,8H-(1,2,4)Triazolo(1,5-a)pyridine14 chemicals, 2 rings
N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide14 chemicals, 2 rings