Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,281 to 2,340 of 15,838 scaffolds
O=C1CCCN1C1CC114 chemicals, 2 rings
1-Phenyl-N-(1H-tetrazol-1-yl)methanimine14 chemicals, 2 rings![Scaffold O=C(CSc1nnc(Cc2ccc[nH]2)n1-c1ccccc1)Nc1ccccc1](/scaffold/AKLWQYMIWMKDCK-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(Cc2ccc[nH]2)n1-c1ccccc1)Nc1ccccc114 chemicals, 4 rings
1-(Diphenylmethyl)azetidine14 chemicals, 3 rings
N-(Phenylcarbamothioyl)pyridine-3-carboxamide14 chemicals, 2 rings
N-[4-(Phenylcarbamoyl)phenyl]furan-2-carboxamide14 chemicals, 3 rings
3-Phenylimidazo(1,5-a)pyridine14 chemicals, 3 rings![Scaffold c1ccc(CCc2nc3ccccc3[nH]2)cc1](/scaffold/BMLOBNVUJHKONU-UHFFFAOYSA-N/structure.svg)
2-(2-Phenylethyl)-1H-benzimidazole14 chemicals, 3 rings
O=C1C=CC(OC(=O)C2CC2)C114 chemicals, 2 rings
O=C(c1ccccc1)N1C=NCC114 chemicals, 2 rings
O=C(COc1ccccc1)Nc1ccccc1N1CCNCC114 chemicals, 3 rings
4-Piperazin-1-yl-quinoline14 chemicals, 3 rings
2-(Phenylthio)pyrimidine14 chemicals, 2 rings![Scaffold O=C(CCc1cn[nH]c1)NN=Cc1ccccc1](/scaffold/CJESFXAZXMEJBY-UHFFFAOYSA-N/structure.svg)
O=C(CCc1cn[nH]c1)NN=Cc1ccccc114 chemicals, 2 rings![Scaffold O=C(CSc1nnc(C2CCCCC2)[nH]1)Nc1ccccc1](/scaffold/CKRKJZMCEGQSPW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(C2CCCCC2)[nH]1)Nc1ccccc114 chemicals, 3 rings![Scaffold S=c1[nH]nc(-c2ccco2)n1-c1ccccc1](/scaffold/CNWLGJLWFORSRE-UHFFFAOYSA-N/structure.svg)
5-Furan-2-yl-4-phenyl-4H-[1,2,4]triazole-3-thiol14 chemicals, 3 rings![Scaffold c1ccc(-c2nc[nH]c2-c2ccccc2)cc1](/scaffold/CPHGOBGXZQKCKI-UHFFFAOYSA-N/structure.svg)
4,5-Diphenylimidazole14 chemicals, 3 rings
N-Cyclohexyl-2-phenoxyacetamide14 chemicals, 2 rings
O=C(Nc1cc2c(s1)CCCC2)c1cccs114 chemicals, 3 rings![Scaffold O=S(=O)(NCCc1c[nH]c2ccccc12)c1ccccc1](/scaffold/CTDQKZGWJQNLIZ-UHFFFAOYSA-N/structure.svg)
N-[2-(1H-Indol-3-yl)ethyl]benzenesulfonamide14 chemicals, 3 rings
4-Phenoxyquinazoline14 chemicals, 3 rings
4-(Azetidin-1-yl)piperidine14 chemicals, 2 rings
1,2,4-Triazolo[4,3-a]pyrimidine14 chemicals, 2 rings
N-Phenyl-3-(phenylsulfonyl)[1,2,3]triazolo[1,5-a]quinazolin-5-amine14 chemicals, 5 rings
2-(1,3-Benzothiazol-2-ylsulfanyl)-N-phenylacetamide14 chemicals, 3 rings
7-(Benzyloxy)-4-phenyl-2H-chromen-2-one14 chemicals, 4 rings![Scaffold c1coc(-c2nc[nH]n2)c1](/scaffold/DRECSUVFISSLIO-UHFFFAOYSA-N/structure.svg)
3-(2-Furyl)-1H-1,2,4-triazole14 chemicals, 2 rings
1,4-Diazepan-2-one14 chemicals, 1 ring
1-Cyclohexylpiperidine14 chemicals, 2 rings
Morpholine, 4-[(2-phenyl-4-quinolinyl)carbonyl]-14 chemicals, 4 rings
6,8-Dioxabicyclo(3.2.1)octane14 chemicals, 2 rings
Julolidine14 chemicals, 3 rings
2,3,4,5-Tetrahydro-1,4-benzoxazepin-5-one14 chemicals, 2 rings
4,4a,5,6,7,8-Hexahydro-2(3H)-naphthalenone14 chemicals, 2 rings![Scaffold c1n[nH]cc1C1CCCO1](/scaffold/FOYHENFBLMAAFF-UHFFFAOYSA-N/structure.svg)
4-(Oxolan-2-yl)-1H-pyrazole14 chemicals, 2 rings
N-Phenyl-2-pyridinemethanamine14 chemicals, 2 rings
2,3-Dihydro-1H-cyclopenta[b]quinoline14 chemicals, 3 rings
2-Benzoylaminobiphenyl14 chemicals, 3 rings![Scaffold O=c1nc[nH]c(=O)[nH]1](/scaffold/GEWRKGDRYZIFNP-UHFFFAOYSA-N/structure.svg)
1,3,5-Triazine-2,4(1H,3H)-dione14 chemicals, 1 ring
O=c1ncnc2ccccn1214 chemicals, 2 rings
Naphthalic anhydride14 chemicals, 3 rings![Scaffold O=c1cc2ccccc2c[nH]1](/scaffold/GYPOFOQUZZUVQL-UHFFFAOYSA-N/structure.svg)
3-Hydroxyisoquinoline14 chemicals, 2 rings
O=C1Nc2ccccc2C1=c1sc2n(c1=O)C(c1cccs1)C=CN=214 chemicals, 5 rings
Bicyclo[3.1.0]hexan-2-one14 chemicals, 2 rings
Pyrrolidine, 1-(N-phenylglycyl)-14 chemicals, 2 rings
O=C(Cn1c(=O)c(CNc2ccccc2)cc2ccccc21)Nc1ccccc114 chemicals, 4 rings
O=C(Nc1cccc(-c2ccc(N3CCOCC3)nn2)c1)c1ccccc114 chemicals, 4 rings
Triphenyl phosphite14 chemicals, 3 rings
O=C(NN=Cc1ccccc1OC(=O)c1ccccc1)c1ccc(OCc2ccccc2)cc114 chemicals, 4 rings
2-Azaspiro[3.5]nonane14 chemicals, 2 rings
O=C1CC(N2CCNCC2)C(=O)N1c1ccccc114 chemicals, 3 rings
O=C(CSc1ccc(-c2cncs2)nn1)Nc1ccccc114 chemicals, 3 rings
Benzyl benzylcarbamate14 chemicals, 2 rings![Scaffold O=c1c(C=Nc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/IROPGVCRCRGUQS-UHFFFAOYSA-N/structure.svg)
O=c1c(C=Nc2ccccc2)c[nH]n1-c1ccccc114 chemicals, 3 rings
9,10-Dihydro-9,10-ethanoanthracene-11,12-dicarboximide14 chemicals, 6 rings
1-Benzylimidazolidin-2-one14 chemicals, 2 rings
O=C(c1ccccc1)c1cc2cccnc2s114 chemicals, 3 rings
5-Azaspiro(3.5)nonane14 chemicals, 2 rings
2-(Phenylmethyl)oxirane14 chemicals, 2 rings
3-Benzyl-chroman-4-one14 chemicals, 3 rings