Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,341 to 2,400 of 15,838 scaffolds
![Scaffold O=c1[nH]cnc2ncc(CNc3ccccc3)nc12](/scaffold/JKBXCYBRFWFQPJ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cnc2ncc(CNc3ccccc3)nc1214 chemicals, 3 rings
(2-Anilino-1,3-thiazol-5-yl)(phenyl)methanone14 chemicals, 3 rings
5-Oxo-1-phenyl-N-(1,3-thiazol-2-yl)pyrrolidine-3-carboxamide14 chemicals, 3 rings
1-Phenyl-3-(pyridin-4-ylmethyl)urea14 chemicals, 2 rings
N-[3-(1-Piperazinyl)phenyl]benzenemethanamine14 chemicals, 3 rings
Phencyclidine14 chemicals, 3 rings![Scaffold O=c1[nH]nc(Cc2ccccc2)c2ccccc12](/scaffold/JUCCMEHWBGPJKS-UHFFFAOYSA-N/structure.svg)
4-Benzyl-1(2H)-phthalazinone14 chemicals, 3 rings![Scaffold c1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3ccnc3)cc2)c1](/scaffold/JVBNNNQTULLPIJ-UHFFFAOYSA-N/structure.svg)
c1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3ccnc3)cc2)c114 chemicals, 4 rings
C1CC2CC3CCCC3(C1)C214 chemicals, 3 rings
Pyridine, 4-[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]-14 chemicals, 3 rings
N-Benzylthieno[2,3-d]pyrimidin-4-amine14 chemicals, 3 rings
1,1,2-Triphenylethane14 chemicals, 3 rings
3,3-Diphenyloxindole14 chemicals, 4 rings
2,3,4,5-Tetrahydro-1-benzoxepin-5-one14 chemicals, 2 rings
O=C(NCC1CCCCC1)OCC1c2ccccc2-c2ccccc2114 chemicals, 4 rings
c1ccc(Oc2ccc(-c3nn(C4CCCNC4)c4ncncc34)cc2)cc114 chemicals, 5 rings
C(=Cc1nc2ccccc2s1)c1ccccc114 chemicals, 3 rings![Scaffold c1ccc(C[N+]23CCC(CC2)CC3Cc2ccnc3ccccc23)cc1](/scaffold/LDOHADPHWULRRC-UHFFFAOYSA-N/structure.svg)
c1ccc(C[N+]23CCC(CC2)CC3Cc2ccnc3ccccc23)cc114 chemicals, 6 rings
O=C(c1ccccc1)c1ccc2ccc3ccccc3n1214 chemicals, 4 rings
2-((6-(Indolin-1-ylmethyl)-4-oxo-4H-pyran-3-yl)oxy)-N-phenylacetamide14 chemicals, 4 rings
O=C1NC(=S)SC1=Cc1ccc(-c2ccccc2)o114 chemicals, 3 rings
1-Phenylisoquinoline14 chemicals, 3 rings
N-(2-Phenylethyl)pyrazine-2-carboxamide14 chemicals, 2 rings
2-Benzyl-6-phenylpyridazin-3(2H)-one14 chemicals, 3 rings
5-Cyclopropyl-1,3-oxazole14 chemicals, 2 rings
O=C(NN=Cc1cn(-c2ccccc2)nn1)c1ccccc114 chemicals, 3 rings
N-(2-Phenylimidazo[1,2-a]pyridin-3-yl)benzamide14 chemicals, 4 rings
O=C(Nc1cc2c(s1)CCCC2)c1ccco114 chemicals, 3 rings![Scaffold O=C(NCc1nnc[nH]1)c1ccccc1](/scaffold/MIIFQDUDGGUXTL-UHFFFAOYSA-N/structure.svg)
N-(1H-1,2,4-Triazol-5-ylmethyl)benzamide14 chemicals, 2 rings
3-Benzyloxy-4-pyrone14 chemicals, 2 rings
2-((4-Benzyl-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl)thio)-N-phenylacetamide14 chemicals, 4 rings
2-(Benzenesulfonyl)pyridine14 chemicals, 2 rings![Scaffold O=c1ccnc(N=CNc2ccccc2)[nH]1](/scaffold/MTSFTQNWPSWYFF-UHFFFAOYSA-N/structure.svg)
O=c1ccnc(N=CNc2ccccc2)[nH]114 chemicals, 2 rings
2,5-Diphenyl-5,6-dihydro-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-one14 chemicals, 4 rings
O=C(C=Cc1ccccc1)Oc1ccccc114 chemicals, 2 rings
1-Piperonylpiperazine14 chemicals, 3 rings![Scaffold O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]1](/scaffold/NDLNPZDGZZJEQK-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]114 chemicals, 3 rings
1,2-Bis(benzyloxy)benzene14 chemicals, 3 rings
N-(4-Pyridin-2-yl-thiazol-2-yl)-benzamide14 chemicals, 3 rings
2-Naphthalenesulfonanilide14 chemicals, 3 rings![Scaffold c1ccc(CSc2ncc[nH]2)cc1](/scaffold/NPBMCLWRSOFTTI-UHFFFAOYSA-N/structure.svg)
2-Benzylmercaptoimidazole14 chemicals, 2 rings
O=C(c1ccccc1)N1CCN(C(=O)c2ccco2)CC114 chemicals, 3 rings
5-(Phenoxymethyl)-N-phenylfuran-2-carboxamide14 chemicals, 3 rings
N-Phenylpiperidine-3-carboxamide14 chemicals, 2 rings
O=C(Nc1ccc(N2CCNCC2)cc1)c1ccco114 chemicals, 3 rings
2-Benzylidene-1,3-indandione14 chemicals, 3 rings
c1ccc(-n2ccc(-c3ccc4c(c3)OCCO4)n2)cc114 chemicals, 4 rings
3-(1H-Pyrazol-1-yl)piperidine14 chemicals, 2 rings
N-Benzyl-2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide14 chemicals, 3 rings
c1ccc(Nc2ccnc3ncnn23)cc114 chemicals, 3 rings
O-(o-Aminophenoxy)benzoic acid lactam14 chemicals, 3 rings
2,6-Diazaspiro(3.4)octane14 chemicals, 2 rings
1,1',1'',1'''-Methanetetrayltetrakis(benzene)14 chemicals, 4 rings
O=C(CSc1nnc(COc2ccccc2)n1-c1ccccc1)c1ccccc114 chemicals, 4 rings
RefChem:38216414 chemicals, 2 rings
1-(2-Phenoxyethyl)piperazine14 chemicals, 2 rings
O=S(=O)(c1ccccc1)N1C=NCC114 chemicals, 2 rings
1-Cyclopentylpiperazine14 chemicals, 2 rings
N1-benzyl-N2-(2-(1-(phenylsulfonyl)piperidin-2-yl)ethyl)oxalamide14 chemicals, 3 rings
O=C1CSC(NN=Cc2ccccc2)=N114 chemicals, 2 rings