Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,401 to 2,460 of 15,838 scaffolds
c1ccc(CSc2nc3ncccn3n2)cc114 chemicals, 3 rings
4H,5H,6H-Cyclopenta[d][1,3]thiazole14 chemicals, 2 rings
O=c1c2ccccc2oc2cc3c(cc12)C=CCO314 chemicals, 4 rings
1,3(2H,4H)-isoquinolinedione14 chemicals, 2 rings
4-(1,3-Thiazol-2-yl)morpholine14 chemicals, 2 rings
O=C(Oc1ccc2occc2c1)c1ccccc114 chemicals, 3 rings
N-[4-(1-Piperidinylsulfonyl)phenyl]benzamide14 chemicals, 3 rings
N-[4-(1,3-Thiazol-2-ylsulfamoyl)phenyl]benzamide14 chemicals, 3 rings![Scaffold O=c1[nH]nc(-c2ccccc2)o1](/scaffold/RFJQGIYJJLWZJP-UHFFFAOYSA-N/structure.svg)
2-Phenyl-1,3,4-oxadiazol-2-IN-5-one14 chemicals, 2 rings
O=c1ncn(-c2ccccc2)cc1-c1ccccc114 chemicals, 3 rings![Scaffold O=c1[nH]cccc1Cc1ccccc1](/scaffold/RKIOBDYNFLHVQZ-UHFFFAOYSA-N/structure.svg)
Benzyl pyridinone14 chemicals, 2 rings![Scaffold S=c1nc2[nH]c3ccccc3c2n[nH]1](/scaffold/RPEJKVRRTJDBSN-UHFFFAOYSA-N/structure.svg)
5H-[1,2,4]Triazino[5,6-b]indole-3-thiol14 chemicals, 3 rings
Alpha-morpholino-N-phenylsuccinimide14 chemicals, 3 rings
1-Cyclopropyl-2-phenylethan-1-one14 chemicals, 2 rings
1-Benzyl-3-oxopiperazine14 chemicals, 2 rings
N-(1,3-Benzothiazol-2-yl)-2-(2,5-dioxopyrrolidin-1-yl)acetamide14 chemicals, 3 rings
C1=Cc2ccccc2C1=Cc1ccccc114 chemicals, 3 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccco2)[nH]n1](/scaffold/SOXGOGZFFPWUGF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc(-c2ccco2)[nH]n114 chemicals, 3 rings
O=S1(=O)CCCc2ccsc2114 chemicals, 2 rings
5,6,7,8-Tetrahydro-1,7-naphthyridine14 chemicals, 2 rings
3-Benzylidenechromen-4-one14 chemicals, 3 rings
C1=C2C3CCCCC3CCC2C2CCC3CC(OC4CCCCO4)CCC3C2C114 chemicals, 6 rings![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=CC=Cc1ccco1](/scaffold/TZIKPOKMALALDY-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=CC=Cc1ccco114 chemicals, 3 rings![Scaffold O=C(CSc1ncn[nH]1)c1ccccc1](/scaffold/UJVOAHVGRTVDDA-UHFFFAOYSA-N/structure.svg)
RefChem:38209214 chemicals, 2 rings
N-(2-Piperidin-1-ylsulfonylethyl)benzamide14 chemicals, 2 rings
c1ccc(-c2ncnn2-c2ccccc2)cc114 chemicals, 3 rings
N-Phenyloxetan-3-amine14 chemicals, 2 rings
2-((1-(2-Morpholino-2-oxoethyl)-1H-indol-3-yl)sulfonyl)-N-phenylacetamide14 chemicals, 4 rings
O=C1C(=O)N(CC2CCCO2)C(c2ccccc2)C1=Cc1ccccc114 chemicals, 4 rings
O=C(Nc1ccc(-c2nc3ncccc3o2)cc1)c1ccccc114 chemicals, 4 rings
3-[(1,3-Benzodioxol-5-yloxi)methyl-]4-phenyl-piperidine14 chemicals, 4 rings
4',5'-Dihydropsoralen14 chemicals, 3 rings
1-Phenylcyclohexene14 chemicals, 2 rings
c1ccc(CCCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)cc114 chemicals, 4 rings
3-Phenylpiperazin-2-one14 chemicals, 2 rings
2-Phenoxy-N-[4-(pyrrolidin-1-ylsulfonyl)phenyl]acetamide14 chemicals, 3 rings
1-(Pyrrolidin-3-yl)-1H-1,2,3-triazole14 chemicals, 2 rings
Bicyclo(3.3.1)nonane14 chemicals, 2 rings
N-(2-Morpholin-4-ylphenyl)pyridine-3-carboxamide14 chemicals, 3 rings
9-Phenyl-5,6,7,9-tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one14 chemicals, 4 rings
O=c1cc(CN2CCNCC2)c2ccccc2o114 chemicals, 3 rings
C1=C2CCC3CCCCC3C2CCC114 chemicals, 3 rings![Scaffold O=c1cnnc(Nc2ccccc2)[nH]1](/scaffold/XJANMFIZMSJZEJ-UHFFFAOYSA-N/structure.svg)
O=c1cnnc(Nc2ccccc2)[nH]114 chemicals, 2 rings
1,2,3,4,4a,5,8,8a-Octahydronaphthalene14 chemicals, 2 rings
2-Phenyl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine14 chemicals, 4 rings
Phenyl-1-naphthylamine14 chemicals, 3 rings
1-(1,3-Thiazol-2-yl)piperidine14 chemicals, 2 rings
1,2,4-Triazolo(4,3-c)pyrimidine14 chemicals, 2 rings
3-Cyclopropyl-1,2,4-oxadiazole14 chemicals, 2 rings
2,3,4,5-Tetrahydro-1-benzoxepine14 chemicals, 2 rings
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4-oxo-4H-chromene-2-carboxamide14 chemicals, 4 rings
2,3-Dihydro-1,4-benzothiazine14 chemicals, 2 rings
Octahydropyrrolo[3,4-b]pyrrole14 chemicals, 2 rings![Scaffold c1cc(C2CCCO2)[nH]n1](/scaffold/YFEXGHZLWGJCQF-UHFFFAOYSA-N/structure.svg)
3-(Oxolan-2-yl)-1H-pyrazole14 chemicals, 2 rings
O=C(Nc1ccccc1)N1CCCCCC114 chemicals, 2 rings
c1ccc(CSc2ncnc3c2ncn3C2CCCO2)cc114 chemicals, 4 rings
O=C1C(=Cc2ccco2)Oc2ccccc2114 chemicals, 3 rings
Cyclopropyl phenyl sulfide14 chemicals, 2 rings
O=S(=O)(NCc1cscn1)c1ccccc114 chemicals, 2 rings
3'-Phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione14 chemicals, 4 rings