Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,521 to 2,580 of 15,838 scaffolds
N-Benzylpiperidin-4-amine13 chemicals, 2 rings
1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole13 chemicals, 3 rings![Scaffold c1ccc2c3c([nH]c2c1)C1CC2CCC1N(CC3)C2](/scaffold/HWGBLBYCKKHAOB-UHFFFAOYSA-N/structure.svg)
c1ccc2c3c([nH]c2c1)C1CC2CCC1N(CC3)C213 chemicals, 6 rings
Morpholin-4-yl-(4-phenyl-piperazin-1-yl)-methanone13 chemicals, 3 rings
2-(1-Pyrrolidinyl)benzothiazole13 chemicals, 3 rings
Benzene, ((cyclohexyloxy)methyl)-13 chemicals, 2 rings![Scaffold S=c1[nH]cc(-c2ccccc2)[nH]1](/scaffold/ISOLPDRTYOTMTO-UHFFFAOYSA-N/structure.svg)
Imidazole-2-thiol, 4-phenyl-13 chemicals, 2 rings
O=C(COc1ccc2ccccc2c1)NN=Cc1ccccc1OC(=O)c1ccccc113 chemicals, 4 rings
3-Phenyl-1-oxoisochroman13 chemicals, 3 rings
3-Cyclopropylazetidine13 chemicals, 2 rings
Tolazoline13 chemicals, 2 rings
Diphenyl sulfoxide13 chemicals, 2 rings
2-((1-(3-Morpholinopropyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-phenylacetamide13 chemicals, 4 rings
C(=NN1CCN(Cc2cccc3ccccc23)CC1)c1ccccc113 chemicals, 4 rings
1-Azabicyclo[2.2.1]heptane13 chemicals, 2 rings
c1cc2c(cc1OC1CCCCO1)CCC1C2CCC2CCCC2113 chemicals, 5 rings
O=C(Nc1c2c(nn1-c1ccccc1)CS(=O)C2)c1ccccc113 chemicals, 4 rings
O=C(CNc1ccccc1)N1CCN(c2ccccc2)CC113 chemicals, 3 rings
N-Phenethylfuran-2-carboxamide13 chemicals, 2 rings
Fenpiprane13 chemicals, 3 rings
2-Furancarboxamide, N-[4-(benzoylamino)phenyl]-13 chemicals, 3 rings![Scaffold [N+]=c1ccc2nc3ccccc3oc-2c1](/scaffold/JZYYOSGPHMFGPQ-UHFFFAOYSA-N/structure.svg)
[N+]=c1ccc2nc3ccccc3oc-2c113 chemicals, 3 rings
1-Phenyl-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione13 chemicals, 3 rings![Scaffold O=C(CSc1nc2ccccc2c(=O)[nH]1)Nc1ccccc1](/scaffold/KDRIURZVJMYZNJ-UHFFFAOYSA-N/structure.svg)
2-[(4-Oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-phenylacetamide13 chemicals, 3 rings
O=C(OC1CCCCO1)C12CCCCC1C1=CCC3C4CCC(OC5CCCCO5)CC4CCC3C1CC213 chemicals, 7 rings
O=C1C=C2CCC3C(=C2CC1)C(c1ccccc1)CC1CCCC1313 chemicals, 5 rings
O=C(c1ccccc1)C1CNCC1c1ccccc113 chemicals, 3 rings![Scaffold O=S(=O)(c1cn[nH]c1)N1CCCCC1](/scaffold/KMFXUJBKEFUODM-UHFFFAOYSA-N/structure.svg)
1-(1H-Pyrazole-4-sulfonyl)piperidine13 chemicals, 2 rings
O=C(NCCCn1ccnc1)C(=Cc1ccccc1)NC(=O)c1ccccc113 chemicals, 3 rings
1-(Isoxazol-3-yl)-3-phenylurea13 chemicals, 2 rings![Scaffold c1ccc(Oc2ccn[nH]2)cc1](/scaffold/KMZIZRHLLMNWNT-UHFFFAOYSA-N/structure.svg)
5-Phenoxy-1H-pyrazole13 chemicals, 2 rings
3,5-Bis(benzylidene)-4-piperidone13 chemicals, 3 rings
c1ccc(C2=NCc3nncn3-c3sccc32)cc113 chemicals, 4 rings
1-Benzhydryl-4-benzylpiperazine13 chemicals, 4 rings
11-(Piperazin-1-yl)dibenzo(b,f)(1,4)oxazepine13 chemicals, 4 rings
c1ccc(Oc2cccc(-c3ccccc3)n2)cc113 chemicals, 3 rings
N-Benzylcyclohexanecarboxamide13 chemicals, 2 rings
S=C(c1ccccc1)N1CCN(c2ccccc2)CC113 chemicals, 3 rings
3,8-Diazabicyclo(3.2.1)octane13 chemicals, 2 rings
O=C1OC2CC(CC=CC(OC3CCC(OC4CCCCO4)CO3)CC=CC=C3COC4CC=CC1C34)OC1(C=CCCO1)C213 chemicals, 7 rings
O=S1(=O)Cc2cn(-c3ccccc3)nc2C113 chemicals, 3 rings
N-(Phenylmethyl)-4-pyridinemethanamine13 chemicals, 2 rings
N-(Pyridin-2-yl)furan-2-carboxamide13 chemicals, 2 rings
1-(Morpholin-4-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethan-1-one13 chemicals, 3 rings
c1ccc(Cc2ncno2)cc113 chemicals, 2 rings![Scaffold N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCCc1ccccc1](/scaffold/MBZPBJFPRPIKBL-UHFFFAOYSA-N/structure.svg)
N=c1[nH]c2nc3ccccn3c(=O)c2cc1C(=O)NCCc1ccccc113 chemicals, 4 rings![Scaffold O=c1[nH]cncc1Cc1ccccc1](/scaffold/MIXSIMGCLDYGMF-UHFFFAOYSA-N/structure.svg)
5-Benzylpyrimidin-4(3H)-one13 chemicals, 2 rings
O=C(CN1C(=O)SC(=Cc2ccccc2)C1=O)NC1CCS(=O)(=O)C113 chemicals, 3 rings![Scaffold O=c1ccn(-c2ccccc2)[nH]1](/scaffold/MKMDCEXRIPLNGJ-UHFFFAOYSA-N/structure.svg)
O=c1ccn(-c2ccccc2)[nH]113 chemicals, 2 rings
4-Phenylazetidin-2-one13 chemicals, 2 rings
c1ccc(C(c2cn3ncnc3s2)N2CCOCC2)cc113 chemicals, 4 rings
O=c1ccnc2scnn1213 chemicals, 2 rings
1-Phenyl-3-(2-(phenylthio)ethyl)thiourea13 chemicals, 2 rings
N-[3-(Phenylcarbamoyl)phenyl]furan-2-carboxamide13 chemicals, 3 rings![Scaffold c1ccc(CNc2ncnc3[nH]ncc23)cc1](/scaffold/NNSLOBNGHHXORI-UHFFFAOYSA-N/structure.svg)
n-Benzyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine13 chemicals, 3 rings
O=C(N1CCNCC1)N(Cc1ccccc1)S(=O)(=O)c1ccccc113 chemicals, 3 rings
O=C(Nc1cccs1)c1ccco113 chemicals, 2 rings
C1=CC(n2cnc3cncnc32)CC113 chemicals, 3 rings
O=C1NC=CC(c2cn(-c3ccccc3)nc2-c2ccccc2)N113 chemicals, 4 rings
O=c1c(=Cc2ccccc2)sc2nc3ccccc3n1213 chemicals, 4 rings