Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,581 to 2,640 of 15,838 scaffolds
O=C(NCc1nc(-c2ccccc2)no1)c1ccoc113 chemicals, 3 rings
O=C(CN1CCN(Cc2ccccc2)CC1)Nc1ccccc113 chemicals, 3 rings![Scaffold S=C(NCCc1c[nH]c2ccccc12)Nc1ccccc1](/scaffold/OISAMYRWTWEYHW-UHFFFAOYSA-N/structure.svg)
1-[2-(1H-Indol-3-yl)ethyl]-3-phenylthiourea13 chemicals, 3 rings
1-(Naphthalene-2-sulfonyl)-piperazine13 chemicals, 3 rings
O=C(Nc1ccc(S(=O)(=O)Nc2ccon2)cc1)c1ccccc113 chemicals, 3 rings
3-Phenyl-5-pyrazolone13 chemicals, 2 rings
O=C(Nc1ccccc1)C12CC3CC(C1)CC(n1cncn1)(C3)C213 chemicals, 6 rings
2-Cyclopropyl-1,3,4-thiadiazole13 chemicals, 2 rings
O=c1cc(CN2CCN(Cc3ccccc3)CC2)c2ccccc2o113 chemicals, 4 rings![Scaffold c1ccc(CSc2nnc(-c3cccs3)[nH]2)cc1](/scaffold/PIMWOFSKCMJDJL-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3cccs3)[nH]2)cc113 chemicals, 3 rings
10,11-Dihydro-5H-dibenzo(a,d)cycloheptene13 chemicals, 3 rings
2-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylethanone13 chemicals, 3 rings
N-(Phenylmethyl)-1,3-benzodioxole-5-methanamine13 chemicals, 3 rings
c1ccc(Nc2nc(-c3cncs3)cs2)cc113 chemicals, 3 rings
3-Anilino-1,5-diphenyl-1,5-dihydro-2H-pyrrol-2-one13 chemicals, 4 rings
N-Phenyl-2-{[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide13 chemicals, 3 rings
c1noc(C2CC2)n113 chemicals, 2 rings
O=c1c(-c2ccccc2)coc2c(CN3CCOCC3)cccc1213 chemicals, 4 rings
O=C(CN1C(=O)C2(SCC(=O)N2c2ccccc2)c2ccccc21)Nc1ccccc113 chemicals, 5 rings
O=C(OC1CCNCC1)C(c1ccccc1)c1ccccc113 chemicals, 3 rings
Succinimide, 2-benzyl-N-phenyl-13 chemicals, 3 rings
C(=Cc1ccccc1)C=Nc1ccccc113 chemicals, 2 rings
4-Cyclobutylpyridine13 chemicals, 2 rings![Scaffold c1ccc(NCc2nc3ccccc3[nH]2)cc1](/scaffold/RICPDSJTBAXDLV-UHFFFAOYSA-N/structure.svg)
N-(1H-Benzimidazol-2-ylmethyl)-N-phenylamine13 chemicals, 3 rings
c1csc(COc2cccc3ccccc23)c113 chemicals, 3 rings
O=C(CNC1CCCCC1)Nc1ccccc113 chemicals, 2 rings
C1=CC2=CCC3CCCCC3C2CC113 chemicals, 3 rings
O=C(C=Cc1ccccc1)Oc1ccc(C=NNC(=O)c2ccccc2)cc113 chemicals, 3 rings
1-Benzothioylpyrrolidine13 chemicals, 2 rings
N-[(3-Phenyl-1,2-oxazol-5-yl)methyl]benzenesulfonamide13 chemicals, 3 rings
C(CCC1CC2C(CC3C2CCC2C4CCC(OC5OCCCC5OC5CCCCO5)CC4CCC23)O1)COC1CCCCO113 chemicals, 8 rings
4,4'-Bi-1,3-benzodioxole-5,5'-diylbis(diphenylphosphine)13 chemicals, 8 rings
O=C(COc1ccccc1)Nc1cc2c(s1)CCC213 chemicals, 3 rings
O=C(Nc1ccccc1N1CCNCC1)c1ccco113 chemicals, 3 rings
N-(1,3,4-Thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide13 chemicals, 3 rings
O=C(CN(C(=O)N1CCNCC1)S(=O)(=O)c1ccccc1)Nc1ccccc113 chemicals, 3 rings
O=C(Nc1ccccc1)c1ccc2ncsc2c113 chemicals, 3 rings
4-Benzoylpyridine13 chemicals, 2 rings
O=C1NC(=S)SC1=CC1=Cc2ccccc2OC113 chemicals, 3 rings
6-Phenylthieno[2,3-b]pyridine13 chemicals, 3 rings
1-Benzyl-N-phenylpyrazolo[3,4-d]pyrimidin-4-amine13 chemicals, 4 rings
N-(5,6,7,8-Tetrahydro-1-naphthyl)benzamide13 chemicals, 3 rings
(4-Benzylpiperidin-1-yl)-phenylmethanone13 chemicals, 3 rings
O=C(NN=Cc1ccccc1)Nc1ccccc113 chemicals, 2 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc2ccccc2[nH]1](/scaffold/SYUQFFCOGGAGKC-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc2ccccc2[nH]113 chemicals, 3 rings
4-Thiazolidinone, 3-phenyl-5-(phenylmethylene)-2-thioxo-, (5Z)-13 chemicals, 3 rings
C1=CC2(Cc3ccccc3N2)Oc2ccccc2113 chemicals, 4 rings![Scaffold O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1ccccc1](/scaffold/UDCSGLFPWKYZPA-UHFFFAOYSA-N/structure.svg)
2-((2-Oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-phenylacetamide13 chemicals, 3 rings
N-(2-(6-((2-Oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide13 chemicals, 4 rings![Scaffold O=C(NC1OC2C3CCCN3C(=O)CN2C1=O)C1C=C2c3cccc4[nH]cc(c34)CC2NC1](/scaffold/UMEFRYIIYVJUHV-UHFFFAOYSA-N/structure.svg)
O=C(NC1OC2C3CCCN3C(=O)CN2C1=O)C1C=C2c3cccc4[nH]cc(c34)CC2NC113 chemicals, 7 rings(c2ccccc2)c2ccccc2)cc1](/scaffold/USFPINLPPFWTJW-UHFFFAOYSA-N/structure.svg)
Tetraphenylphosphonium13 chemicals, 4 rings
Phenyl phenylacetate13 chemicals, 2 rings
2-([1]Benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-phenylacetamide13 chemicals, 4 rings
O=C(Nc1ccccc1)c1ccc(S(=O)(=O)N2CCCC2)cc113 chemicals, 3 rings
1,1a,6,6a-Tetrahydrocycloprop(a)indene13 chemicals, 3 rings
1-(Phenylthioxomethyl)piperidine13 chemicals, 2 rings
Bicyclo(2.2.2)octan-2-one13 chemicals, 3 rings
N,N-Dibenzylbenzamide13 chemicals, 3 rings![Scaffold O=c1[nH]cnc2c1CCCC2](/scaffold/VLGSBIJEQBQFCJ-UHFFFAOYSA-N/structure.svg)
4(3H)-Quinazolinone, 5,6,7,8-tetrahydro-13 chemicals, 2 rings
[4-Oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] benzoate13 chemicals, 3 rings