Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,641 to 2,700 of 15,838 scaffolds
6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazine13 chemicals, 3 rings
O=S(=O)(C=CNc1ccccc1)c1ccccc113 chemicals, 2 rings
Benzyl 2-naphthyl ether13 chemicals, 3 rings
O=C(CCc1ccccc1)Nc1ccc2ccccc2c113 chemicals, 3 rings
2-Cyclopropylpyrrolidine13 chemicals, 2 rings
O=C(c1ccccc1)N(c1ccccc1)C1C=CS(=O)(=O)C113 chemicals, 3 rings
C1CC2COCCN2C113 chemicals, 2 rings
O=c1c(OC2CCCCO2)c(-c2ccccc2)oc2cc(OC3CCCCO3)ccc1213 chemicals, 5 rings![Scaffold S=c1[nH]cc(-c2ccccc2)n1-c1ccccc1](/scaffold/WVWPIDMVMOHYEG-UHFFFAOYSA-N/structure.svg)
1,5-Diphenyl-1H-imidazole-2-thiol13 chemicals, 3 rings
O=c1c(=Cc2ccc(-c3ccccc3)o2)sc2n1C(c1ccccc1)C=CN=213 chemicals, 5 rings
O=C1CCC2C3Cc4cccc5c4C2(CCN3CC2CC2)C1O513 chemicals, 6 rings
2,8-Diazaspiro(4.5)decane13 chemicals, 2 rings
1-Phenyl-3-(4-pyridyl)urea13 chemicals, 2 rings
O=c1c2c(ncn1-c1ccccc1)CCS213 chemicals, 3 rings
Isopsoralen13 chemicals, 3 rings
7,8,9,10-Tetrahydrotetracene-5,12-dione13 chemicals, 4 rings
2-(3,5-Dioxothiomorpholino)-N-phenylacetamide13 chemicals, 2 rings![Scaffold O=C(Nc1ncn[nH]1)c1ccccc1](/scaffold/XGLLDHTXWOIYCZ-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ncn[nH]1)c1ccccc113 chemicals, 2 rings![Scaffold O=c1cnn(-c2ccccc2)c(=O)[nH]1](/scaffold/XGPCOQNUQVZURR-UHFFFAOYSA-N/structure.svg)
2-Phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione13 chemicals, 2 rings
O=C1NCc2cncn2-c2ccccc2113 chemicals, 3 rings
N-[2-(Morpholin-4-yl)phenyl]furan-2-carboxamide13 chemicals, 3 rings
3-(1,3-Benzothiazol-2-ylsulfanyl)-1-phenylpyrrolidine-2,5-dione13 chemicals, 4 rings![Scaffold O=c1[nH]c(=O)c2[nH]c(N3CCNCC3)nc2[nH]1](/scaffold/XPLSBZLHKGHHDJ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(N3CCNCC3)nc2[nH]113 chemicals, 3 rings![Scaffold c1csc(-c2nc3ccccc3[nH]2)c1](/scaffold/XXCGVPNWMZKOER-UHFFFAOYSA-N/structure.svg)
2-(2-Thienyl)-1H-benzimidazole13 chemicals, 3 rings
1-Phenylpyrrolidine-2,4-dione13 chemicals, 2 rings
c1ccc(C(c2cn3ncnc3s2)N2CCNCC2)cc113 chemicals, 4 rings
1,1-Diphenylcyclopropane13 chemicals, 3 rings![Scaffold O=c1nc[nH]c2c1NCCN2](/scaffold/YMYLCENGLBCRLP-UHFFFAOYSA-N/structure.svg)
5,6,7,8-Tetrahydropteridin-4(1H)-one13 chemicals, 2 rings
1-(Azetidin-3-yl)piperazine13 chemicals, 2 rings![Scaffold O=c1ccc2ccc(OCc3nn[nH]n3)cc2o1](/scaffold/YSRZSDDRXAYUBU-UHFFFAOYSA-N/structure.svg)
O=c1ccc2ccc(OCc3nn[nH]n3)cc2o113 chemicals, 3 rings
C(=C1CCc2cc3ccccc3nc21)c1ccccc113 chemicals, 4 rings
2-(Azetidin-3-yl)pyridine13 chemicals, 2 rings![Scaffold O=c1[nH]ncn1-c1ccc(N2CCN(c3ccc(OCC4COC(Cn5cncn5)(c5ccccc5)O4)cc3)CC2)cc1](/scaffold/ZBPFXGFYXTVEGK-UHFFFAOYSA-N/structure.svg)
O=c1[nH]ncn1-c1ccc(N2CCN(c3ccc(OCC4COC(Cn5cncn5)(c5ccccc5)O4)cc3)CC2)cc113 chemicals, 7 rings![Scaffold O=C(CSc1ncn[nH]1)NCc1ccccc1](/scaffold/ZBSYLOJDGBMFAD-UHFFFAOYSA-N/structure.svg)
N-Benzyl-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide13 chemicals, 2 rings
1-Phenyl-4,5,6,7-tetrahydro-1H-indazole13 chemicals, 3 rings
N=c1ccc2c(=O)n3ccccc3nc2n1Cc1cccnc113 chemicals, 4 rings
Furan, 2,5-diphenyl-tetrahydro-13 chemicals, 3 rings
2-Phenyl-1,3-thiazolidin-4-one13 chemicals, 2 rings
O=C(c1ccccc1)c1ccc2c3ccccc3cnn1213 chemicals, 4 rings
Perimidine12 chemicals, 3 rings
S=C(c1ccccc1)N1CCNCC112 chemicals, 2 rings
2-Phenyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one12 chemicals, 3 rings
1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one12 chemicals, 3 rings
2,4-Imidazolidinedione, 3-(phenylmethyl)-12 chemicals, 2 rings
N=c1ccc2c(=O)n3ccccc3nc2n1CCc1ccccc112 chemicals, 4 rings![Scaffold O=c1ccc(B2OCCO2)c[nH]1](/scaffold/ATDNLZHDTTYXFH-UHFFFAOYSA-N/structure.svg)
O=c1ccc(B2OCCO2)c[nH]112 chemicals, 2 rings
O=C(Nc1ccc2cc(N=Nc3ccccc3)ccc2c1)Nc1ccc2cc(N=Nc3ccccc3)ccc2c112 chemicals, 6 rings
9,11,12,13,13a,14-Hexahydrophenanthro[9,10-f]indolizine12 chemicals, 5 rings![Scaffold O=S(=O)(c1ccccc1)N1CCC(c2nc3ccccc3[nH]2)CC1](/scaffold/BGAYELMDHYVQTP-UHFFFAOYSA-N/structure.svg)
2-(1-(Phenylsulfonyl)piperidin-4-yl)-1H-benzo[d]imidazole12 chemicals, 4 rings![Scaffold O=c1[nH]c2ccccc2c(=O)n1-c1ccccc1](/scaffold/BHQNJNLXFVJFFI-UHFFFAOYSA-N/structure.svg)
3-Phenylquinazoline-2,4-dione12 chemicals, 3 rings
O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(CC1CCCO1)C2=O12 chemicals, 4 rings
2-(Thiophen-2-yl)pyrrolidine12 chemicals, 2 rings
4-Phenylamino-chromen-2-one12 chemicals, 3 rings
O=C1CCCC2=C1C(c1ccccc1)C=CN2c1cc2c(s1)CCCCC212 chemicals, 5 rings
1-Cyclohexyl-5-oxo-N-phenylpyrrolidine-3-carboxamide12 chemicals, 3 rings
4,6-Diphenylpyrimidine12 chemicals, 3 rings
O=C(Nc1ccc(S(=O)(=O)N2CCNCC2)cc1)c1ccccc112 chemicals, 3 rings
2-Benzylsulfanyl-1,3-benzoxazole12 chemicals, 3 rings![Scaffold O=C(c1ccccc1)c1ccc2nc[nH]c2c1](/scaffold/CGVCBANYMPJILL-UHFFFAOYSA-N/structure.svg)
(1H-Benzimidazol-6-yl)(phenyl)methanone12 chemicals, 3 rings![Scaffold c1ccc(Nc2cc[nH]n2)cc1](/scaffold/CMAOIURPBUCSJE-UHFFFAOYSA-N/structure.svg)
c1ccc(Nc2cc[nH]n2)cc112 chemicals, 2 rings