Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,701 to 2,760 of 15,838 scaffolds
Phenidone12 chemicals, 2 rings
O=C(CNS(=O)(=O)c1ccccc1)N1CCCC112 chemicals, 2 rings
Methanone, 2-furanylphenyl-12 chemicals, 2 rings
O=C1NC(=S)SC1=Cc1c(N2CCOCC2)nc2ccccn2c1=O12 chemicals, 4 rings
Dibenzocyclooctadiene12 chemicals, 3 rings
N-Phenyl-4-(tetrazol-1-yl)benzamide12 chemicals, 3 rings
2-(4-Phenylpiperazin-1-yl)-N-(1,3-thiazol-2-yl)acetamide12 chemicals, 3 rings
2-(Azetidin-3-yl)pyrimidine12 chemicals, 2 rings
[1,2,4]Triazolo[1,5-a]pyrazine12 chemicals, 2 rings
S=C(NN=Cc1ccc(OCc2ccccc2)cc1)Nc1ccccc112 chemicals, 3 rings![Scaffold O=c1[nH]c(=O)c2c(nc3n(-c4ccccc4)c(-c4ccccc4)cn23)[nH]1](/scaffold/DFQBXYIOCBTMIP-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(nc3n(-c4ccccc4)c(-c4ccccc4)cn23)[nH]112 chemicals, 5 rings![Scaffold O=C(NCc1nc2ccccc2[nH]1)c1ccccc1](/scaffold/DLPWNQUPBLICPH-UHFFFAOYSA-N/structure.svg)
N-[(1H-1,3-Benzodiazol-2-yl)methyl]benzamide12 chemicals, 3 rings
O=C1C=CC(c2ccccc2)N1c1ccccn112 chemicals, 3 rings![Scaffold O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1c[nH]c2ccccc12](/scaffold/DQYBRTASHMYDJG-UHFFFAOYSA-N/structure.svg)
Arcyriarubin A12 chemicals, 5 rings
Phenothiazine-5-oxide12 chemicals, 3 rings
N-Benzyl-N-(1,1-dioxidotetrahydro-3-thienyl)-2-oxo-2H-chromene-3-carboxamide12 chemicals, 4 rings
c1cnn(C2CCOC2)c112 chemicals, 2 rings
N-(Benzylideneamino)-4-phenyl-1,3-thiazol-2-amine12 chemicals, 3 rings
c1ccc2c(c1)c1ccccc1n2CCCN1CCNCC112 chemicals, 4 rings![Scaffold c1cc(C2CCCNC2)n[nH]1](/scaffold/DZMZZFAVAYXTJD-UHFFFAOYSA-N/structure.svg)
3-(1H-Pyrazol-5-yl)piperidine12 chemicals, 2 rings
O=C(C=Cc1ccccc1)N1CCN(c2ccccc2)CC112 chemicals, 3 rings
2(1H)-Isoquinolinecarbothioamide, 3,4-dihydro-N-phenyl-12 chemicals, 3 rings![Scaffold O=C(COc1ccccc1)NCCc1nc2ccccc2[nH]1](/scaffold/FEZFATXEYHLKNH-UHFFFAOYSA-N/structure.svg)
N-[2-(1H-Benzimidazol-2-yl)ethyl]-2-phenoxyacetamide12 chemicals, 3 rings![Scaffold O=C(c1cc2ccccc2[nH]1)N1CCN(c2ccccc2)CC1](/scaffold/FFTYTNLKTHIRTM-UHFFFAOYSA-N/structure.svg)
1H-Indol-2-yl-(4-phenylpiperazin-1-yl)methanone12 chemicals, 4 rings
O=C(Nc1ccccc1)c1ccon112 chemicals, 2 rings
O=C(C1=CC(=O)N(CCCn2ccnc2)C1c1ccccc1)c1ccco112 chemicals, 4 rings
C(=NNc1ncccn1)c1ccccc112 chemicals, 2 rings
O=C(Cn1ccc2ccccc2c1=O)Nc1ccccc112 chemicals, 3 rings
2-(Piperidin-1-yl)pyrazine12 chemicals, 2 rings
3-(Azetidin-3-yl)-1,2-oxazole12 chemicals, 2 rings
Spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one12 chemicals, 3 rings
2,3,3a,4,5,6-Hexahydro-1H-pyrazino[3,2,1-jk]carbazole12 chemicals, 4 rings
O=C(OCC1c2ccccc2-c2ccccc21)N1CCC(c2ccccc2)C112 chemicals, 5 rings
N-Cyclobutylaniline12 chemicals, 2 rings
c1ccc(Cc2cccc(C3CCCCO3)c2)cc112 chemicals, 3 rings![Scaffold c1ccc(CSc2nnc(-c3cnccn3)[nH]2)cc1](/scaffold/FWDCPYGRSZADLJ-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3cnccn3)[nH]2)cc112 chemicals, 3 rings
c1nnc2n1CCCCC212 chemicals, 2 rings
c1ccc2nc3c(nc2c1)C1CCC3C112 chemicals, 4 rings
O=C1C=C2C3CCCCC3CCC2C2CCC3CC(OC4OCCCC4OC4CCCCO4)CCC3C1212 chemicals, 7 rings
c1ccc2c(c1)CCNC2CC1CCN2CCc3ccccc3C2C112 chemicals, 5 rings
O=C1NC=C(C(=O)OC2CCCCC2)C(c2ccccc2)N112 chemicals, 3 rings
2-(3-Pyridyl)benzoxazole12 chemicals, 3 rings
c1ccc(C2OCC3C(c4ccc5c(c4)OCO5)OCC23)cc112 chemicals, 5 rings
4-Phenyl-2-(piperazin-1-yl)quinazoline12 chemicals, 4 rings![Scaffold O=c1ccc2c([nH]1)CCC2](/scaffold/GXXRRIYKTZNCNC-UHFFFAOYSA-N/structure.svg)
1H,2H,5H,6H,7H-Cyclopenta(b)pyridin-2-one12 chemicals, 2 rings
O=C1CCC=CCC(=O)CC(CCC2CCCCC2)OC(=O)C2CCCCN2C(=O)C(=O)C2CCCC(CCC=CC=CC=CCCC1)O212 chemicals, 4 rings
O=C(Nc1ccccc1)Nc1ccc2c(c1)OCO212 chemicals, 3 rings
c1ccc(Oc2ccnc(-c3ccccn3)n2)cc112 chemicals, 3 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1ccc(OCc2ccccc2)cc112 chemicals, 3 rings
c1ccc(OC2CCC2)cc112 chemicals, 2 rings
1H,2H,3H,4H-Pyrido(2,3-b)pyrazine12 chemicals, 2 rings
c1ccc(Nc2cccc3nc4ccccc4n23)cc112 chemicals, 4 rings
Hexahydro-1H-furo[3,4-c]pyrrole12 chemicals, 2 rings
Benzanthrone12 chemicals, 4 rings
O=S(=O)(C=Cc1ccccc1)Nc1ccccc112 chemicals, 2 rings![Scaffold O=C(Nc1ccccc1)c1cnc[nH]1](/scaffold/HYPSKNLBXKFNBB-UHFFFAOYSA-N/structure.svg)
Imidazole-4-carboxanilide12 chemicals, 2 rings
1-(Benzenesulfonyl)-4-benzylpiperidine12 chemicals, 3 rings
1-(Phenoxyacetyl)indoline12 chemicals, 3 rings
1,4-Diphenyl-2-azetidinone12 chemicals, 3 rings
5,6,7,8-Tetrahydropteridine12 chemicals, 2 rings